Raf

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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Raf

Raf kinases are a family of three serine/threonine-specific protein kinases that are related to retroviral oncogenes.Rapidly Accelerated Fibrosarcoma is referred to as RAF. The RAS-RAF-MEK-ERK signal transduction cascade, also known as the mitogen-activated protein kinase (MAPK) cascade, involves Raf kinases. Interaction with RAS-GTPases is necessary for RAF kinase activation. A-RAF, B-RAF, and C-RAF (Raf-1) are the three members of the RAF kinase family. The B-Raf protein is involved in transmitting signals within cells that control cell growth.It was demonstrated that it was flawed (mutated) in a few human cancers. The RAF1 gene in humans encodes the enzyme C-RAF, also known as Raf-1. The c-Raf protein is a MAP kinase kinase (MAP3K) that works after the Ras subfamily of membrane-associated GTPases. It is a component of the ERK1/2 pathway. C-Raf is a member of the TKL (Tyrosine-kinase-like) group of protein kinases and belongs to the Raf kinase family of serine/threonine-specific protein kinases.

Raf related products

Cat No.	Product Name	CAS No.	Product Description
V116023	BRAFV600E-IN-3		BRAFV600E-IN-3 (compound AV05) is a BRAFV600E inhibitor with an IC50 value of 0.89 μM.
V114247	BRAFV600E/ABL2-IN-1		BRAFV600E/ABL2-IN-1 is a dual inhibitor of BRAFV600E (IC50 = 0.088 μM) and ABL2 (IC50 = 0.3 μM).
V99901	Brimarafenibum	1643326-82-2	Brimarafenib is a rapidly accelerating fibrosarcoma (Raf) kinase inhibitor with antitumor effects.
V2661	CCT196969	1163719-56-9	CCT196969 (CCT-196969) is a novel, orally bioavailable, pan-RAF inhibitor (IC50 = 0.1 μM) with anti-SRC and anticancer activity.
V131438	CG 858-Neg	2417296-83-2	CG 858-Neg is a negative control for thalidomide-derived PROTAC degraders, targeting BRAF and BRAFV600E, with Ki values of 9.5 nM and 14.4 nM, respectively.
V6701	CID-25014542	220904-99-4	Raf inhibitor 2 is a potent raf kinase inhibitor (IC50<1.0 μM), compound 32, developed from EP1003721B1 patent.
V119346	CST905	3094183-98-6	CST905 is a highly efficient PROTAC BRAF-V600E degrader with a DC50 of 18 nM.
V74145	Dabrafenib-d9 (GSK2118436A-d9; GSK2118436-d9)	1423119-98-5	Dabrafenib-d9 is the deuterated form of dabrafenib.
V94037	Doramapimod hydrochloride	1283526-53-3	Doramamod hydrochloride (BIRB 796 hydrochloride) is an anti-inflammatory compound that exhibits biological activity through inhibition of p38 MAPK.
V134934	EGFR/BRAFV600E-IN-4		EGFR/BRAFV600E-IN-4 is a dual inhibitor of EGFR and BRAFV600E, with IC50 values of 61 nM and 43 nM, respectively.
V79297	Encorafenib-13C,d3 (LGX818-13C,d3)		Encorafenib-13C,d3 is a 13C- and deuterated-labeled encorafenib.
V74144	Everafenib	2923700-82-5	Everafenib is a potent and BBB (blood-brain barrier) permeable (penetrable) BRAF inhibitor that also inhibits the MAPK pathway.
V99971	Flezurafenibum	2760321-00-2	Flezurafenibum (Flezurafenib) is a rapidly accelerated fibrosarcoma (Raf) kinase inhibitor with antitumor effects.
V1005	GDC-0879	905281-76-7	GDC-0879 (AR-00341677;GDC-0879; AR00341677) is a novel, potent, highly selective, and orally bioavailable B-Raf kinase inhibitor with potential antitumor activity.
V51457	GNE-9815	2729996-45-4	Type II pan-RAF inhibitor
V1011	GW5074	220904-83-6	GW5074 (GW-5074; GW 5074) is a novel, potent and selective c-Raf inhibitor with potential neuroprotective activity.
V98048	IHMT-RAF-128	2479289-15-9	IHMT-RAF-128 is a potent pan-RAF inhibitor.
V74140	ISIS 5132 (CGP 69846A; ISIS 9271)	177075-18-2	ISIS 5132 is an oligonucleotide that specifically downregulates c-raf expression.
V80402	ISIS 5132 sodium (CGP 69846A sodium; ISIS 9271 sodium)		ISIS 5132sodium is an oligonucleotide that specifically downregulates c-raf expression.
V138097	ISIS 5132 sodium scrambled negative control		The ISIS 5132 sodium scrambled negative control is a negative control with the sequence of ISIS 5132 sodium salt scrambled.