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p38 MAPK

p38 MAPK

The p38 MAPK family consists of highly conserved proline-directed serine-threonine protein kinases that are activated in response to a number many growth factors, cytokines, and chemotactic substances, such as vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), PDGF, TNF, interleukins, lipopolysaccharide (LPS) and formyl-methionyl-leucyl-phenylalanine (fMLP).It is well known that p38 plays a role in cell differentiation, cardiomyocyte hypertrophy, apoptosis, and inflammation.

The four proteins that make up the p38 MAPK family are p38 (encoded by the gene Mapk14), p38 (Mapk11), p38 (Mapk12), and p38 (Mapk13). Their coding genes appear to be differentially expressed and have a distinct tissue distribution, with Mapk14 being the most highly expressed. MKK6, MKK3, and MKK4 are three MAP2Ks that p38 MAPKs are a substrate for. Depending on the stimulus and the cell type, each of these MAP2Ks plays a different role in the activation of p38 MAPKs. ASK1, DLK1, TAK1, TAO1, TAO2, TPL2, MLK3, MEKK3, MEKK4, and ZAK1 are the MAP3Ks that activate p38 MAPKs.

p38 MAPK related products

Structure Cat No. Product Name CAS No. Product Description
p38 Kinase inhibitor 7 V142065 p38 Kinase inhibitor 7 815595-14-3 p38 Kinase Inhibitor 7 is an inhibitor of p38α with an IC50 of 5.25 nM.
p38 Kinase-IN-9 V118349 p38 Kinase-IN-9 836682-64-5 p38 kinase-IN-9 (Example 4) is a p38 kinase inhibitor with IC50 <1 μM.
p38 MAP Kinase Inhibitor VI V74124 p38 MAP Kinase Inhibitor VI 421578-46-3 p38 MAP Kinase Inhibitor VI (compound c32) is a p38 MAPK inhibitor (antagonist) with an inhibition rate of 24%.
p38 MAP Kinase-IN-1 V142067 p38 MAP Kinase-IN-1 815595-27-8 p38 MAP Kinase-IN-1 is an inhibitor of p38 and can be used in studies related to inflammation and autoimmune responses.
p38 MAP Kinase-IN-2 V116698 p38 MAP Kinase-IN-2 165806-09-7 p38 MAP kinase-IN-2 (compound 5) is a p38 MAP kinase inhibitor.
p38 MAP Kinase-IN-3 V116399 p38 MAP Kinase-IN-3 384820-17-1 p38 MAP kinase-IN-3 is a p38 MAP kinase inhibitor (IC50 = 0.09 µM).
p38 MAP Kinase-IN-4 V142068 p38 MAP Kinase-IN-4 1228148-61-5 p38 MAP Kinase-IN-4 is a p38α MAPK inhibitor with an IC50 of 40.5 nM.
p38 MAP modulator V51698 p38 MAP modulator 773104-07-7 modulator of p38 Mitogen-Activated Protein (MAP) kinase
p38 MAPK-IN-10 V142069 p38 MAPK-IN-10 340041-97-6 p38 MAPK-IN-10 is an orally effective and potent p38 MAP kinase inhibitor (IC50 = 570 nM).
p38 MAPK-IN-4 V74107 p38 MAPK-IN-4 219138-24-6 p38 MAPK-IN-4 (compound 6) is a p38 MAPK inhibitor, 50 at 35 nM.
p38 MAPK-IN-6 V142071 p38 MAPK-IN-6 421578-44-1 p38 MAPK-IN-6 is a p38 MAPK inhibitor.
p38 MAPK-IN-7 V142072 p38 MAPK-IN-7 165806-50-8 p38 MAPK-IN-7 is an orally effective and highly selective p38 MAP kinase inhibitor (IC50 = 170 nM).
p38 MAPK-IN-8 V142073 p38 MAPK-IN-8 208182-49-4 p38 MAPK-IN-8 is an orally effective, highly potent, and selective inhibitor of p38 mitogen-activated protein kinase (p38 MAPK).
p38 MAPK-IN-9 V142074 p38 MAPK-IN-9 180869-17-4 p38 MAPK-IN-9 is an orally active and highly selective inhibitor of p38α mitogen-activated protein kinase (p38 MAPK) with an IC50 value of 9.6 nM.
p38-α MAPK-IN-10 V142078 p38-α MAPK-IN-10 200801-77-0 p38-α MAPK-IN-10 is an inhibitor of p38α with an IC50 of 4 nM.
p38-α MAPK-IN-11 V110359 p38-α MAPK-IN-11 p38-α MAPK-IN-11 (compound 4C) is a selective, blood-brain barrier-crossing p38α MAPK inhibitor with an IC50 value of 43 nM.
p38-α MAPK-IN-6 V87098 p38-α MAPK-IN-6 29368-40-9 p38-α MAPK-IN-6 (compound 3a) is a p38α mitogen-activated protein kinase inhibitor.
p38-α MAPK-IN-7 V87096 p38-α MAPK-IN-7 p38-α MAPK-IN-7 (compound 4) is a p38α-MAPK inhibitor with IC50 of 98.7 nM.
p38-α MAPK-IN-9 V142079 p38-α MAPK-IN-9 868272-50-8 p38-α MAPK-IN-9 is a p38-α MAPK inhibitor (Ki: 0.057 nM).
p38α inhibitor 2 V74127 p38α inhibitor 2 1095003-80-7 p38α inhibitor 2 is a highly efficient and selective p38α MAPK inhibitor (antagonist) with pIC50 of 9.6.
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