p38 MAPK

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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p38 MAPK

The p38 MAPK family consists of highly conserved proline-directed serine-threonine protein kinases that are activated in response to a number many growth factors, cytokines, and chemotactic substances, such as vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), PDGF, TNF, interleukins, lipopolysaccharide (LPS) and formyl-methionyl-leucyl-phenylalanine (fMLP).It is well known that p38 plays a role in cell differentiation, cardiomyocyte hypertrophy, apoptosis, and inflammation.

The four proteins that make up the p38 MAPK family are p38 (encoded by the gene Mapk14), p38 (Mapk11), p38 (Mapk12), and p38 (Mapk13). Their coding genes appear to be differentially expressed and have a distinct tissue distribution, with Mapk14 being the most highly expressed. MKK6, MKK3, and MKK4 are three MAP2Ks that p38 MAPKs are a substrate for. Depending on the stimulus and the cell type, each of these MAP2Ks plays a different role in the activation of p38 MAPKs. ASK1, DLK1, TAK1, TAO1, TAO2, TPL2, MLK3, MEKK3, MEKK4, and ZAK1 are the MAP3Ks that activate p38 MAPKs.

p38 MAPK related products

Cat No.	Product Name	CAS No.	Product Description
V87096	p38-α MAPK-IN-7		p38-α MAPK-IN-7 (compound 4) is a p38α-MAPK inhibitor with IC50 of 98.7 nM.
V74127	p38α inhibitor 2	1095003-80-7	p38α inhibitor 2 is a highly efficient and selective p38α MAPK inhibitor (antagonist) with pIC50 of 9.6.
V74126	p38α inhibitor 4	1262406-08-5	p38α inhibitor 4 (compound 10) is a selective allosteric p38α inhibitor (antagonist) with IC50 of 1.2 μM.
V103651	p38α inhibitor 5	2550397-96-9	p38α inhibitor 5 (compound 1) is a PROTAC-type target protein ligand that targets p38 and can be used to synthesize NR-11c.
V108989	p38α-IN-10	180869-29-8	p38α-IN-10 (compound 8) is an orally effective p38α inhibitor with an IC₅₀ of 230 nM.
V109036	p38α-IN-11	1357621-20-5	p38α-IN-11 (compound 16c) is a p38α inhibitor with a KD value of 586 nM.
V104549	p38α-MK2-IN-1	3031770-03-0	p38α-MK2-IN-1 (Compound 36) is a p38α-MK2 complex inhibitor (IC50: 5 nM).
V3010	PD 169316	152121-53-4	PD 169316 is a novel potent, cell-permeable and specific/selective inhibitor of p38 MAPK kinase with IC50 value of 89 nM.
V84278	Pestanoid A
V0481	PH-797804	586379-66-0	PH-797804 (PH797804), a diarylpyridinone analog,is a novel, potent, selective and ATP-competitive inhibitor of p38 mitogen-activated protein (p38α) with potential anti-inflammatory and anticancer activity.
V74121	PLK1/p38γ-IN-1	2418614-81-8	PLK1/p38γ-IN-1 (compound 14) is a multi-target inhibitor of PLK1 and p38γ.
V114747	PMK1-IN-1		PMK1-IN-1 (compound H17) is a potent PMK1 inhibitor.
V93145	PS-166276	348089-57-6	PS-166276 is a potent and low cytotoxic p38 inhibitor.
V4141	R1487 HCl	449808-64-4	R1487 HCl is a novel, potent, orally bioavailable, and highly selective inhibitor of p38α mitogen-activated protein kinase.
V110995	rel-Talmapimod hydrochloride	879132-01-1	rel-Talmapimod (rel-SCIO-469) hydrochloride is an orally potent and selective p38α MAPK inhibitor with an IC50 of 9 nM.
V87091	SB 203580 sulfone	152121-46-5	SB 203580 sulfone is an analog of the p38 MAP kinase inhibitor SB 203580, inhibits IL-1 production in monocytes with an IC50 of 0.2 μM, and competitively binds to CSAID binding protein (CSBP), inhibiting CSBP activity and suppressing its-mediated stress response signaling with an IC50 of 0.03 μM.
V74110	SB 706504	911110-38-8	SB 706504 is a potent p38 MAPK inhibitor that can suppress Lipopolysaccharides-stimulated macrophage inflammatory gene expression in chronic obstructive pulmonary disease (COPD).
V2950	SB-242235	193746-75-7	SB-242235 is a potent and selective p38 MAP kinase inhibitor with IC50 of 1.0 uM and has the potential for treatment of cytokine-mediated diseases like autoimmune or inflammatory diseases.
V0478	SB202190 (FHPI)	152121-30-7	SB-202190 (known also as SB202190; FHPI) is a novel, highly selective, potent and cell-permeable inhibitor of p38 MAPK with potential antiseptic activity.
V0483	SB239063	193551-21-2	SB239063 (SB-239063) is a novel, highly potent, orally bioactive and selective p38 MAPKα/β inhibitor with potential anti-inflammatory activity.