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JNK

JNK

JNK (c-Jun N-terminal kinase), a kinase subfamily belonging to the MAPK, is activated in response to various stress stimuli and possesses a wide variety of regulatory functions.Three isoforms of the serine/threonine protein kinase JNK family (JNK1, JNK2, and JNK3) exist. JNKs play a role in the development and progression of many pathologies, including cancer, inflammatory diseases, cardiovascular and metabolic disorders, and neurodegenerative diseases.

JNKs are triggered by a phosphorylation cascade that typically involves two different upstream kinases, the so-called MAP kinase kinase kinases (MAP3K, MKKK) and the MAP kinase kinases (MAP2K; MKK). This process is similar to that used to activate the other MAP kinases. JNKs are triggered by MKK4 and MKK7 at the MAP2K level; the former is a shared activator of the JNK and p38 MAP kinase signaling pathways. The JNK cascade is a component of a complicated signaling network since it crosses numerous other routes at different places.

JNK related products

Structure Cat No. Product Name CAS No. Product Description
JNK-IN-23 V138282 JNK-IN-23 1007786-48-2 JNK-IN-23 is a JNK inhibitor.
JNK-IN-25 V114252 JNK-IN-25 1644498-54-3 JNK-IN-25 is a highly potent and selective JNK1/2/3 inhibitor with IC50 values of 1.54 nM (JNK1), 1.99 nM (JNK2), and 0.75 nM (JNK3), respectively.
JNK-IN-26 V138284 JNK-IN-26 2727965-47-9 JNK-IN-26 is a JNK inhibitor.
JNK-IN-7 V12253 JNK-IN-7 1408064-71-0 JNK-IN-7 is a potent JNK inhibitor, inhibiting JNK1, JNK2 and JNK3 with IC50 of 1.5, 2 and 0.7 nM respectively.
JNK1 degrader-1 V138271 JNK1 degrader-1 JNK1 degrader-1 is a JNK1 HyT degrader.
JNK1 ligand-1 V138272 JNK1 ligand-1 325702-67-8 JNK1 ligand-1 is a JNK1 ligand that can be used to synthesize PROTACs, such as PROTAC JNK1 degrader-1.
JNK1 ligand-1-NH-Ph-COOH V138273 JNK1 ligand-1-NH-Ph-COOH 3047792-63-9 JNK1 ligand-1-NH-Ph-COOH is a selective JNK1 inhibitor.
JNK2 Recombinant Human Active Protein Kinase V116590 JNK2 Recombinant Human Active Protein Kinase JNK2 is a neuron-specific subtype of JNK.
JNK2-IN-1 V78318 JNK2-IN-1 2998941-15-2 JNK2-IN-1 (Compound J27) is a JNK2 inhibitor (Kds: 79.2 Μm).
JNK2/3-IN-1 V138275 JNK2/3-IN-1 JNK2/3-IN-1 is an irreversible covalent c-Jun N-terminal kinase 2/3 (JNK2/3) inhibitor with IC50 values of 830 nM and 1909 nM, respectively.
JNK3 inhibitor-3 V74392 JNK3 inhibitor-3 2873465-25-7 JNK3 inhibitor-3 (compound 15g) is a selective, BBB (blood-brain barrier) penetrating, orally bioactive c-Jun N-terminal kinase 3 (JNK3) inhibitor.
JNK3 inhibitor-6 V80457 JNK3 inhibitor-6 JNK3 inhibitor-6 (Compound A53) is a selective JNK3 inhibitor (IC50=78 nM).
JNK3 inhibitor-8 V80458 JNK3 inhibitor-8 JNK3 inhibitor-8 is a specific, orally bioactive JNK3 inhibitor that can cross the BBB (blood-brain barrier).
JNK3 Recombinant Human Active Protein Kinase V116625 JNK3 Recombinant Human Active Protein Kinase JNK3 is a neuron-specific subtype of JNK.
JNK3-IN-10 V138279 JNK3-IN-10 3085181-00-3 JNK3-IN-10 is a JNK3 inhibitor that is impermeable to the blood-brain barrier (IC50 = 0.257 nM) and has a selectivity for JNK1 that is more than 400 times greater.
JNK抑制剂5a V0473 TCS JNK 5a 312917-14-9 TCS JNK 5a (alsoknown asJNK Inhibitor IX; TCS JNK-5a) is a novel, highly selective and potent JNK (c-Jun N-terminal Kinase) inhibitor with potential antineoplastic activity.
JNK抑制剂8 V0472 JNK-IN-8 1410880-22-6 JNK-IN-8 (JNK Inhibitor XVI; JNK-IN8) is the first irreversible/covalent inhibitor of pan-JNK (c-Jun N-terminal Kinase) with potential antitumor activity.
JNK抑制剂VIII V28892 JNK Inhibitor VIII (TCS JNK 6o) 894804-07-0 JNK Inhibitor VIII (TCS JNK 6o) isa selective and ATP-competitive inhibitor of c-Jun N-terminal kinases (JNK-1, -2, and -3) with Kis of 2 nM, 4 nM, 52 nM, respectively, and has IC50 of 45 nM and 160 nM for JNK-1 and -2, respectively.
KB-R7943 甲磺酸盐 V9844 KB-R7943 mesylate 182004-65-5 KB-R7943 mesylate, the mesylate salt of KB-R-7943, is a novel and potent reverse Na(+) /Ca(2+) exchanger (NCX(rev)) with neuroprotective action.
L-JNKI-1 V51552 L-JNKI-1 L-JNKI-1 is a cell-penetrable peptide inhibitor of JNK.
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