ERK

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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ERK

ERKs (Extracellular-signal-regulated kinases) are widely expressed protein kinase intracellular signalling molecules that are involved in functions including the regulation of meiosis, mitosis, and postmitotic functions in differentiated cells.The ERK pathway is activated by a wide range of stimuli, including as growth factors, cytokines, viral infection, ligands for heterotrimeric G protein-coupled receptors, transforming agents, and carcinogens. Ras stimulates c-Raf in the MAPK/ERK pathway, which is subsequently joined by mitogen-activated protein kinase kinase (also known as MKK, MEK, or MAP2K), followed by MAPK1/2 (see below).

Ras can be triggered by additional cues in addition to growth hormones through GRB2/SOS and receptor tyrosine kinases. Many transcription factors, including ELK1, and some downstream protein kinases are known to be activated by ERKs. Ras, c-Raf, and receptors like HER2 are known to cause disruption of the ERK pathway, which is frequently seen in malignancies.

ERK related products

Cat No.	Product Name	CAS No.	Product Description
V4122	MK-8353	1184173-73-6	MK-8353 (also known as SCH900353; SCH-900353) is a novel, potent, selective and orally bioavailable ERK inhibitor with anticancer activity.
V116036	MK-8353 hydrochloride	1951448-73-9	MK-8353 (SCH900353) hydrochloride is a potent, selective, orally effective ERK1/2 inhibitor with IC50 values of 23.0 nM and 8.8 nM, respectively.
V69819	mSIRK (G-Protein βγ Binding Peptide)	593267-11-9	mSIRK (G-Protein βγ Binding Peptide) is a cell-permeable (penetrable) activator of ERK1/2 with EC50 of 2.5-5 μM.
V87065	mSIRK TFA		mSIRK TFA (G-Protein βγ Binding Peptide) is a cell-permeable ERK1/2 activator with EC50 of 2.5-5 μM.
V80864	Myristoyl-MEK1 Derived Peptide Inhibitor 1		Myristoyl-MEK1 Derived Peptide Inhibitor 1 is the myristoylated form of MEK1 Derived Peptide Inhibitor 1.
V87066	Napyradiomycin B4		Napyradiomycin B4 is a napyradiomycin derivative that inhibits RANKL-induced MEK-ERK signaling pathway.
V69800	Pamoic acid disodium (disodium pamoate; disodium acetylate; disodium pamoic acid salt)	6640-22-8	Pamoic acid disodium is a potent GPR35 agonist/activator with EC50 of 79 nM.
V88085	PKCδ substrate	915155-20-3	PKCδ substrate serves as a nuclear transport protein of ERK2 and participates in ERK2-mediated gene activation.
V69822	POP-3MB	1144114-27-1	POP-3MB (compound 1b) is an isoprenylcysteine carboxyl methyltransferase (ICMT) inhibitor (IC50= 2.5 μM).
V69811	Prolylserine	71835-80-8	Prolylserine is a dipeptide that is an inhibitor (blocker/antagonist) of melanin production in Mel-Ab cells.
V4794	Rineterkib (LTT-462; ERK-IN-1)	1715025-32-3	Rineterkib (LTT-462; ERK-IN-1; ERK-IN1), the compound B extracted from WO2018051306A1, is a novel and potent RAF and ERK1/2 inhibitor with anticancer activity.
V51449	Rineterkib hydrochloride	1715025-34-5	ERK1/2 inhibitor
V0463	SCH772984	942183-80-4	SCH772984 (SCH-772984) is a novel, potent and ATP-competitive inhibitor of ERK1/2 with potential antitumor activity.
V89649	Serum thymic factor acetate	125117-65-9	Serum thymic factor acetate (Thymulin acetate) is the acetate form of Serum thymic factor.
V69743	SHP2-IN-23	2415989-91-0	SHP2-IN-23 (compound 30) is an orally bioactive SHP2 inhibitor (IC50=38 nM) with excellent in vivo activity and pharmacokinetic characteristics.
V69831	SHR2415	2494010-42-1	SHR2415 is a potent and specific ERK1/2 inhibitor (antagonist) with oral activity.
V104207	SOS1 activator 2	2245237-54-9	SOS1 activator 2 (compound 65) is a benzimidazole derivative and an activator of SOS1.
V69824	STE-MEK1(13) (Ste-MPKKKPTPIQLNP-NH₂; ERK Activation Inhibitor Peptide)	566872-15-9	STE-MEK1(13) (Ste-MPKKKPTPIQLNP-NH2) is a cell-penetrating/penetrable ERK1/2 inhibitor (IC50= 13-30μM).
V69812	TAT-MEK1	566872-16-0	TAT-MEK1 is an inhibitor (blocker/antagonist) of ERK2, consisting of TAT and MEK1 (N-terminal).
V3178	Temuterkib (LY3214996)	1951483-29-6	Temuterkib (formerly LY3214996; LY-3214996) is a selective, ATP-competitive and orally bioavailable inhibitor of the ERK1 (extracellular signal-regulated kinase) and ERK2 with potential anticancer activity. It inhibits ERK1/2 with IC50 value of 5 nM in biochemical assays.