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Drug-Linker Conjugates for ADC

Drug-Linker Conjugates for ADC

The components of drug-linker conjugates for antibody drug conjugates (ADCs) are a cytotoxic drug that is active and a suitable linker. These conjugates can be used to create ADCs, which are highly selective and cytotoxic agents that are targeted for cancer cells after being joined to a monoclonal antibody.

The drug units in drug-linker conjugates are tubulin inhibitors and DNA damaging agents that have antitumor activity (i.e., ADC cytotoxins or payloads). Auristatins and Maytansinoids are the most widely used tubulin inhibitors, while Duocarmycins, Pyrrolobenzodiazepines, Camptothecines, and Daunorubicins/Doxorubicines are the most frequently used DNA damaging agents in ADCs. Additionally, a variety of conventional cytotoxic agents can be used in ADCs.

Cleavable and noncleavable ADC linkers are the two categories into which the majority of those currently undergoing clinical evaluation fall. Noncleavable linkers necessitate proteolytic degradation of the antibody component of the ADC in order to release the cytotoxic molecule, whereas cleavable linkers depend on cellular processes to release the toxin.

Drug-Linker Conjugates for ADC related products

Structure Cat No. Product Name CAS No. Product Description
APN-PEG5-VC-PAB-MMAE V88401 APN-PEG5-VC-PAB-MMAE APN-PEG5-VC-PAB-MMAE is the drug-linker conjugate portion of INA03, a transferrin-competitive antibody-drug conjugate targeting CD71.
ATAC21 V3218 ATAC21 2101204-23-1 ATAC21 is a linker immunostimulatory compound formed by conjugating a non-cleavable (non-degradable) maleimide-PEG4 linker containing a succinimide group to an immunostimulatory compound.
ATR ligand 2-CO-Ph-COOH V129620 ATR ligand 2-CO-Ph-COOH ATR ligand 2-CO-Ph-COOH is a target protein ligand-linker conjugate containing an ATR ligand and a PROTAC linker, which recruits E3 ligases.
Azide-PEG4-VC-PAB-Doxorubicin V77219 Azide-PEG4-VC-PAB-Doxorubicin Azide-PEG4-VC-PAB-Doxorubicin is made up of linker Azide-PEG4-VC-PAB and toxic molecule Doxorubicin, and may be utilized to prepare antibody-drug-conjugates/ADCss.
Azido-PEG4-Val-Cit-PAB-MMAE V54765 Azido-PEG4-Val-Cit-PAB-MMAE 1869126-64-6 Azido-PEG4-Val-Cit-PAB-MMAE is part of the antibody conjugate active molecule (drug-linker conjugate for ADC).
Barzuxetan (CHX-A''-DTPA-NCS) V54800 Barzuxetan (CHX-A''-DTPA-NCS) 157380-45-5 Barzuxetan may be utilized in study/research of cancer diseases.
BCPT02 V116660 BCPT02 3025473-38-2 BCPT02 (page 64) is a drug linker conjugate used for the synthesis of bispecific antibody-drug conjugates (ADCs).
Bi-Mc-VC-PAB-MMAE V52994 Bi-Mc-VC-PAB-MMAE 1620837-70-8 Bi-Mc-VC-PAB-MMAE is made up of ADC linker (Fmoc-Val-Cit-PAB) and MMAE, which is a potent (tubulin) inhibitor.
Biotin-PEG7-Maleimide V76161 Biotin-PEG7-Maleimide 1898221-65-2 Biotin-PEG7-Maleimide is a biotinylation reagent that reacts with thiol (SH) groups.
Bis(vinylsulfonyl)piperazine-triazole-PEG3-O-diisopropylsilyl-triptolide V130312 Bis(vinylsulfonyl)piperazine-triazole-PEG3-O-diisopropylsilyl-triptolide Bis(vinylsulfonyl)piperazine-triazole-PEG3-O-diisopropylsilyl-triptolide is a drug-linker conjugate used in antibody-drug conjugates (ADCs).
Bis-Mal-Lysine-PEG4-DBCO V130328 Bis-Mal-Lysine-PEG4-DBCO 3113277-32-7 Bis-Mal-Lysine-PEG4-DBCO is a binder for AOC drugs and can be used to synthesize AOC drugs that inhibit DMPK gene expression.
Bis-sulfone-(PEG24)-Glu-Val-Cit-PAB-MMAE V117603 Bis-sulfone-(PEG24)-Glu-Val-Cit-PAB-MMAE 3103526-19-5 Disulfone-(PEG24)-Glu-Val-Cit-PAB-MMAE is a component of antibody-drug conjugates (ADCs).
BL20-MMAE V130369 BL20-MMAE 2765612-38-0 BL20-MMAE is an antibody-drug conjugate targeting ROR1, which is formed by conjugating an anti-ROR1 antibody to the Auristatin payload MMAE via the BL20 linker.
Boc-Lys-PEG8-N-bis(D-glucose) V84764 Boc-Lys-PEG8-N-bis(D-glucose) 2892350-30-8
Boc-Val-Cit-PAB-MMAE V116964 Boc-Val-Cit-PAB-MMAE 2226611-21-6 Boc-Val-Cit-PAB-MMAE is a drug-linker conjugate for antibody-drug conjugates (ADCs), consisting of the linker Boc-Val-Cit-PAB and the microtubule inhibitor MMAE.
BQ7859 V130595 BQ7859 BQ7859 is a probe targeting PSMA, containing a Nota chelating agent, and exhibits excellent imaging performance.
BQ7876 V130596 BQ7876 BQ7876 is a probe that targets prostate-specific membrane antigen (PSMA) and contains a DOTA chelator.
Br-C1-CONH-C5-CO-Val-Cit-PAB-MMAE V130611 Br-C1-CONH-C5-CO-Val-Cit-PAB-MMAE 1350456-57-3 Br-C1-CONH-C5-CO-Val-Cit-PAB-MMAE is a drug-linker conjugate comprising a monomethylaurestatin E (MMAE) drug moiety linked to a bromoacetamide-containing extension unit via a valine-citrulline (Val-Cit) dipeptide and a self-cleaving p-aminobenzyl (PAB) spacer group.
Br-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT V51374 Br-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT 2857037-70-6 drug-linker conjugate for ADC
BrAA-glycine-BG-PAB-Exatecan V130597 BrAA-glycine-BG-PAB-Exatecan 3059866-62-2 BrAA-glycine-BG-PAB-Exatecan is a drug-linker conjugate for antibody-drug conjugates (ADCs), consisting of ethathecan and a linker.
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