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Drug-Linker Conjugates for ADC

Drug-Linker Conjugates for ADC

The components of drug-linker conjugates for antibody drug conjugates (ADCs) are a cytotoxic drug that is active and a suitable linker. These conjugates can be used to create ADCs, which are highly selective and cytotoxic agents that are targeted for cancer cells after being joined to a monoclonal antibody.

The drug units in drug-linker conjugates are tubulin inhibitors and DNA damaging agents that have antitumor activity (i.e., ADC cytotoxins or payloads). Auristatins and Maytansinoids are the most widely used tubulin inhibitors, while Duocarmycins, Pyrrolobenzodiazepines, Camptothecines, and Daunorubicins/Doxorubicines are the most frequently used DNA damaging agents in ADCs. Additionally, a variety of conventional cytotoxic agents can be used in ADCs.

Cleavable and noncleavable ADC linkers are the two categories into which the majority of those currently undergoing clinical evaluation fall. Noncleavable linkers necessitate proteolytic degradation of the antibody component of the ADC in order to release the cytotoxic molecule, whereas cleavable linkers depend on cellular processes to release the toxin.

Drug-Linker Conjugates for ADC related products

Structure Cat No. Product Name CAS No. Product Description
8-Arm-PEG20000-Methyl acrylate V127715 8-Arm-PEG20000-Methyl acrylate 2451100-15-3
8-Arm-PEG20000-Norbornene V127716 8-Arm-PEG20000-Norbornene
8-Arm-PEG40000-Acrylamide V127727 8-Arm-PEG40000-Acrylamide
8-Arm-PEG40000-Acrylate V127728 8-Arm-PEG40000-Acrylate 2111799-19-8
8-Arm-PEG40000-DBCO V127732 8-Arm-PEG40000-DBCO
8-Arm-PEG40000-Methyl acrylate V127734 8-Arm-PEG40000-Methyl acrylate 2451100-15-3
8-Arm-PEG40000-Norbornene V127735 8-Arm-PEG40000-Norbornene
Ac-Lys-Val-Cit-PABC-MMAE formic V77295 Ac-Lys-Val-Cit-PABC-MMAE formic Ac-Lys-Val-Cit-PABC-MMAE (formic) is part of the antibody conjugate active molecule ADC.
Ac-RKAA-PABC-MMAE V128219 Ac-RKAA-PABC-MMAE 2768774-89-4 Ac-RKAA-PABC-MMAE is a drug-linker conjugate used in antibody-drug conjugates (ADCs).
AcLysValCit-PABC-DMAE-SW-163D V35242 AcLysValCit-PABC-DMAE-SW-163D 2411007-69-5 AcLysValCit-PABC-DMAE-SW-163D is part of the active antibody coupling molecule (drug-linker conjugates for ADC), which is made up of natural dual intercalator SW-163D and linker AcLysValCitPABC-DMAE coupling.
ADC 38 drug linker V110531 ADC 38 drug linker ADC 38 is a drug linker conjugate for antibody-drug conjugates (ADCs) that contains a CD4 mimic and a linker.
ADC-5 drug-linker V128297 ADC-5 drug-linker ADC-5 drug-linker is a drug linker conjugate used in antibody-drug conjugates (ADCs) with potent antitumor activity.
ADC-VI V115115 ADC-VI 3031725-06-8 ADC-VI (compound 6) is a conjugate of a toxic molecule and a linker, in which CPD6 carries the cytotoxic drug drutecan.
Amine-PEG8-Val-Cit-PAB-MMAE V128719 Amine-PEG8-Val-Cit-PAB-MMAE 2879227-86-6 Amine-PEG8-Val-Cit-PAB-MMAE is a highly effective antibody-drug conjugate (ADC).
Amino-PEG4-GGFG-Dxd V88381 Amino-PEG4-GGFG-Dxd 2879227-88-8 Amino-PEG4-GGFG-Dxd (Compound 13-7) is a drug-linker conjugate composed of Dxd and linker, which can be used for the synthesis of ADC.
Aminocaproyl-Val-Cit-PABC-MMAE V88382 Aminocaproyl-Val-Cit-PABC-MMAE 1374407-35-8 Aminocaproyl-Val-Cit-PABC-MMAE is a drug-linker conjugate used in the synthesis of ADC.
Aniline-PEG3-C1-Boc V93149 Aniline-PEG3-C1-Boc 2115897-27-1 Aniline-PEG3-C1-Boc (Compound D-1) is an intermediate for polymer-linked cytotoxic drugs.
APL-1082 V118421 APL-1082 2921735-93-3 APL-1082 (Mc-exo-EVC-Exatecan) is a drug-linker conjugate that can be used in ADC synthesis. Its structure contains Exatecan (ADC payload) and a linker.
APL-1091 V129270 APL-1091 2921735-87-5 APL-1091 is part of a drug linker conjugate for antibody-drug conjugates (ADCs).
APL-1092 V104596 APL-1092 2921735-91-1 APL-1092 (Mal-Exo-EEVC-Exatecan) is a drug-linker complex that can be used for ADC synthesis.
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