yingweiwo
  1. Home
  2. Products
  3. Signaling Pathways
  4. ADC Related
  5. ADC Cytotoxin

ADC Cytotoxin

ADC Cytotoxin

ADC cytotoxins, also referred to as payloads, are cytotoxic substances that cause the death of target cells in ADCs (antibody drug conjugates). A monoclonal antibody, a linker, and a cytotoxin are the components of an ADC, which is a targeted agent. The cytotoxin is the most crucial component because it determines how effective an ADC is at killing cancer cells.

Numerous cytotoxins, including calicheamicins, duocarmycins, pyrrolobenzodiazepines (PBDs), camptothecins, daunorubicins/doxorubicins, auristatins, and maytansinoids, are currently in use. Based on how they work, they can be classified as either DNA-damaging agents or tubulin inhibitors. Among them are DNA minor groove binders like Calicheamicins, Duocarmycins, and PBDs as well as topoisomerase inhibitors like Camptothecins and Daunorubicins/Doxorubicins, which damage DNA. Tubulin inhibitors include auristatins and maytansinoids. There are numerous conventional cytotoxic agents with comparable mechanisms of killing cancer cells that can also be used in the development of ADCs in addition to the listed cytotoxins.

ADC Cytotoxin related products

Structure Cat No. Product Name CAS No. Product Description
NH2-Gly-PAB-Exatecan-D-glucuronic acid V88357 NH2-Gly-PAB-Exatecan-D-glucuronic acid 2763252-31-7 NH2-Gly-PAB-Exatecan-D-glucuronic acid (Compound 8) is an intermediate that reacts with the NHS group to form the ADC drug-linker conjugate, Mal-Gly-PAB-Exatecan-D-glucuronic acid.
NH2-Gly-PAB-Exatecan-D-glucuronic acid formic V88352 NH2-Gly-PAB-Exatecan-D-glucuronic acid formic NH2-Gly-PAB-Exatecan-D-glucuronic acid formic (Compound 8) is the formate salt form of NH2-Gly-PAB-Exatecan-D-glucuronic acid.
NH2-methylpropanamide-Exatecan TFA V54483 NH2-methylpropanamide-Exatecan TFA 1817857-35-4 NH2-methylpropanamide-Exatecan (TFA) is an isobutylamide-modified Exatecan , which is a common ADC toxin (ADC Cytotoxin) and may be used in the synthesis/preparation of ADC.
NMS-P528 V54480 NMS-P528 1466546-45-1 NMS-P528 is a Duocarmycin analogue that can be used as an ADC payload.
NMT-IN-7 V103771 NMT-IN-7 3032302-70-5 NMT-IN-7 is an N-myristoyltransferase (NMT) inhibitor with IC50 of 2.1 nM for HsNMT1M and 0.6 nM for SU-DHL-10 cells.
O-Me Eribulin V98102 O-Me Eribulin 2676196-81-7 O-Me Eribulin is a derivative of Eribulin and is an ADC cytotoxin.
PBD-monoamide V83368 PBD-monoamide 2093165-00-3
PNU-159682 V4152 PNU-159682 202350-68-3 PNU-159682 (PNU) is a highly potent metabolite of the anthracycline nemorubicin (MMDX)with excellent cytotoxicity.
PNU-159682 carboxylic acid V51211 PNU-159682 carboxylic acid 1204819-92-0 cytotoxin for ADCs
ProAlk01 V143177 ProAlk01 1296670-84-2 ProAlk01 is a protein alkylating agent that can be used as a toxic payload for antibody-drug conjugates (ADCs).
PROTAC BRD4 Degrader-5-CO-PEG3-N3 V53125 PROTAC BRD4 Degrader-5-CO-PEG3-N3 2704602-92-4 PROTAC BRD4 Degrader-5-CO-PEG3-N3 (Compound 2) A PROTAC-linker conjugate for PAC, containing the BRD4 degrader GNE-987 and 3 PEG linkers.
PTDA-PEG4-azide V92058 PTDA-PEG4-azide 2639395-40-5 PTAD-PEG4-N3 is a cleavable ADC linker containing 4 PEG units, which can be used to synthesize antibody-conjugated active molecules (ADCs).
S-Me-DM4 V53138 S-Me-DM4 890654-03-2 S-Me-DM4 is a metabolite produced by S-methylation of part of DM4 by intracellular enzymes.
Sandramycin (山卓霉素) V37627 Sandramycin 100940-65-6 Sandramycin is a cyclic decapeptide antibiotic extracted from the culture medium of Nocardioides sp.
seco-CBI dimer V144735 seco-CBI dimer 2592397-70-9 seco-CBI dimer is a DNA alkylating agent and a prodrug of Ducardim, which can be used as a payload for synthesizing antibody-drug conjugates (ADCs).
seco-CBI-PBD dimer V144736 seco-CBI-PBD dimer 550356-40-6 seco-CBI-PBD dimer is a CBI-PBD heterodimer and also a DNA minor groove cross-linking agent.
Seco-DUBA V37124 Seco-DUBA 1227961-59-2 Seco-DUBA is a prodrug of docarmycin (DUBA) that contains two hydroxyl groups, each of which can be conjugated to an antibody through a linker.
Seco-DUBA hydrochloride V53331 Seco-DUBA hydrochloride 1795733-93-5 Seco-DUBA HCl is the toxin molecule of the ADC drug SYD985.
Seco-Duocarmycin SA V54467 Seco-Duocarmycin SA 144667-38-9 Seco-Duocarmycin SA is a DNA alkylating agent that works as the toxin part of Antibody-drug conjugates (ADC).
Seco-Duocarmycin TM V54469 Seco-DuocarmycinTM 236102-87-7 Seco-Duocarmycin TM is a DNA alkylating agent of the Duocarmycins family that can inhibit DNA synthesis.
Contact Us
Tel: 1-708-310-1919 Fax: 1-708-557-7486 Email: [email protected] Frequently Asked Questions
Subscribe to our E-newsletter
Name
E-mail

Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved

linkedin facebook
Contact Us
Home Product Cart Member