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ADC Cytotoxin

ADC Cytotoxin

ADC cytotoxins, also referred to as payloads, are cytotoxic substances that cause the death of target cells in ADCs (antibody drug conjugates). A monoclonal antibody, a linker, and a cytotoxin are the components of an ADC, which is a targeted agent. The cytotoxin is the most crucial component because it determines how effective an ADC is at killing cancer cells.

Numerous cytotoxins, including calicheamicins, duocarmycins, pyrrolobenzodiazepines (PBDs), camptothecins, daunorubicins/doxorubicins, auristatins, and maytansinoids, are currently in use. Based on how they work, they can be classified as either DNA-damaging agents or tubulin inhibitors. Among them are DNA minor groove binders like Calicheamicins, Duocarmycins, and PBDs as well as topoisomerase inhibitors like Camptothecins and Daunorubicins/Doxorubicins, which damage DNA. Tubulin inhibitors include auristatins and maytansinoids. There are numerous conventional cytotoxic agents with comparable mechanisms of killing cancer cells that can also be used in the development of ADCs in addition to the listed cytotoxins.

ADC Cytotoxin related products

Structure Cat No. Product Name CAS No. Product Description
Glucocorticoid receptor agonist-5 V93026 Glucocorticoid receptor agonist-5 2913231-72-6 Glucocorticoid receptor agonist-5 (compound 4) is a glucocorticoid molecule and a potent glucocorticoid receptor agonist.
Gly-Cyclopropane-Exatecan V54474 Gly-Cyclopropane-Exatecan 2414254-49-0 Gly-Cyclopropane-Exatecan (compound 5c) participates in the synthesis/preparation of anti-B7-H4 antibody active molecular conjugates (ADC), containing the DNA topoisomerase I (Top I) inhibitor Exatecan .
Gly-Gly-Phe-Gly-NH-O-CO-Exatecan V99943 Gly-Gly-Phe-Gly-NH-O-CO-Exatecan 1599440-12-6 Gly-Gly-Phe-Gly-NH-O-CO-Exatecan is an ADC toxin.
Hemiasterlin derivative-1 V54487 Hemiasterlin derivative-1 1887046-60-7 Hemiasterlin analogue-1 is a hemiasterlin analogue.
Hydrotecan V137675 Hydrotecan 2694026-68-9 Hydrotecan is a camptothecin derivative that can be used as an antibody-drug conjugate (ADC) cytotoxic agent.
Hygrolidin V51961 Hygrolidin 83329-73-1 Hygrolidin is a 16-membered macrolide antibiotic derived from Streptomyces hygroscopicus D-1166.
Luisol A V53423 Luisol A 225110-59-8 Luisol A is an aromatic tetraol that is the major metabolite of estuarine marine actinomycetes of the genus Streptomyces.
Maytansinoid B V51807 Maytansinoid B 1628543-40-7 Maytansinoid B is an ADC Cytotoxin that can be coupled with antibodies to form Antibody-Drug Conjugates (ADCs).
MMAF-methyl ester V100024 MMAF-methyl ester 2353409-70-6 MMAF-methyl ester is an ADC toxin.
MMAF-OMe V29041 MMAF-OMe 863971-12-4 MMAF-OMe (Monomethyl auristatin F methyl ester-O-methyl), an auristatin-derived anticancer agent, is a novel and potent warhead used in ADC (antibody-drug conjugate).
MMAF-OtBu V88353 MMAF-OtBu 745017-95-2 MMAF-OtBu ( Example 2) is a modified MMAF.
Modified MMAF V51229 Modified MMAF 1352202-47-1 ADC cytotoxin
Muscotoxin A V41147 Muscotoxin A 1653999-47-3 Muscotoxin A is ADC cytotoxin.
Mycobacterium Tuberculosis-IN-2 V85199 Mycobacterium Tuberculosis-IN-2 2284580-65-8
MYX1715 V88355 MYX1715 2445448-66-6 MYX1715 is an inhibitor of N-myristoyltransferase (NMT) with a KD of 0.09 nM.
N-Ac-γ-Calicheamicin-AcBut-NHS ester V102480 N-Ac-γ-Calicheamicin-AcBut-NHS ester 174885-02-0 AcBut-N-Ac-γ-Calicheamicin is an ADC toxic molecule that induces cell cycle arrest and apoptosis by inducing DNA double-strand breaks.
N-Me-L-Ala-maytansinol V37613 N-Me-L-Ala-maytansinol 77668-69-0 N-Me-La L a-maytansinol is a hydrophobic, cell-penetrating/penetrable payload for the preparation of active antibody conjugates (ADCs).
N2'-脱乙酰基-N2'-（4-巯基-4-甲基-1-氧代戊基）美坦新 V25076 Maytansinoid DM4 796073-69-3 Maytansinoid DM4, a naturally occuring maytansine analogue, is a highly potent/cytotoxic antitubulin agent with anticancer properties.
NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT V54472 NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT 2857037-69-3 NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT (compound I) is a topoisomerase I inhibitor that can be targeted and delivered to cells through conjugated antibodies and has good ADC activity in vivo and in vitro.
NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride V76704 NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT(compound I) HCl is a topoisomerase I inhibitor that can be targeted and delivered to cells through conjugated antibodies and has good in vitro and in vivo ADC activity.
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