ADC cytotoxins, also referred to as payloads, are cytotoxic substances that cause the death of target cells in ADCs (antibody drug conjugates). A monoclonal antibody, a linker, and a cytotoxin are the components of an ADC, which is a targeted agent. The cytotoxin is the most crucial component because it determines how effective an ADC is at killing cancer cells.
Numerous cytotoxins, including calicheamicins, duocarmycins, pyrrolobenzodiazepines (PBDs), camptothecins, daunorubicins/doxorubicins, auristatins, and maytansinoids, are currently in use. Based on how they work, they can be classified as either DNA-damaging agents or tubulin inhibitors. Among them are DNA minor groove binders like Calicheamicins, Duocarmycins, and PBDs as well as topoisomerase inhibitors like Camptothecins and Daunorubicins/Doxorubicins, which damage DNA. Tubulin inhibitors include auristatins and maytansinoids. There are numerous conventional cytotoxic agents with comparable mechanisms of killing cancer cells that can also be used in the development of ADCs in addition to the listed cytotoxins.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V77054 | Dxd-d5 (Exatecan-d5 derivative for ADC) | Dxd-d5 is the deuterium labelled form of Dxd. | |
|
V88356 | EBET-1055 | EBET-1055 is a bromodomain and extra-terminal (BET) protein degrader (EBET), consisting of a BET inhibitor (EBET-590), an E3 ubiquitin ligase ligand, and a linker. | |
|
V76102 | Eg5-IN-2 | 1629735-05-2 | Eg5-IN-2 (Compound Scaffold B (4)) is an Eg5 inhibitor (IC50= < 0.5 nM). |
|
V77028 | Exatecan analog 36 | Exatecan analog 36 is a homologue of Exatecan. | |
|
V103496 | Exatecan analogue 1 | 2671770-58-2 | Exatecan analog 1 (Icp-3) is an analog of Exatecan. |
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V52990 | Exatecan Intermediate 1 (Exatecan Intermediate) | 110351-94-5 | Exatecan Intermediate 1 (compound 6) is an intermediate of Exatecan. |
|
V105543 | Exatecan intermediate 12 | 110351-93-4 | Exatecan intermediate 12 is an intermediate in the synthesis of ADC toxin Exatecan and can be used to prepare ADC compounds. |
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V53196 | Exatecan Intermediate 2 | 182182-31-6 | Exatecan Intermediate 2 (compound B) is an intermediate of Exatecan (DX-8951). |
|
V77027 | Exatecan Intermediate 2 hydrochloride | 2437603-23-9 | Exatecan Intermediate 2 HCl (compound B) is an intermediate of Exatecan (DX-8951). |
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V54466 | Exatecan mesylate dihydrate (DX-8951 mesylate dihydrate) | 197720-53-9 | Exatecan (DX-8951) mesylate dihydrate is a DNA topoisomerase I (Top I) inhibitor (antagonist) with IC50 of 2.2 μM (0.975 μg/mL) and may be utilized in cancer research. |
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V100228 | Exatecan-2-(aminomethoxy)acetamide-Gly-Fmoc | 1599440-09-1 | Exatecan-2-(aminomethoxy)acetamide-Gly-Fmoc is an ADC toxin. |
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V54482 | Exatecan-methylacetamide-OH | 2594423-51-3 | Exatecan-methylacetamide-OH (compound 6) is an Exatecan analogue with anti-cancer effects. |
|
V92054 | Fmoc-Ala-Ala-Ala-amide-C-O-C-COOH | 3002986-41-3 | Fmoc-Ala-Ala-Ala-amide-COC-COOH is a cleavable ADC linker. |
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V53395 | Fmoc-MMAE | 474645-26-6 | Fmoc-MMAE is a protecting group conjugated to MMAE. |
|
V75825 | Fmoc-MMAF-OMe | 863971-38-4 | Fmoc-MMAF-OMe is an anticancer agent and tubulin polymerization inhibitor (antagonist) with Fmoc protecting group. |
|
V85389 | Glucocorticoid receptor agonist-3 | 2842165-73-3 | |
|
V85736 | Glucocorticoid receptor agonist-4 | 2842165-72-2 | |
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V93026 | Glucocorticoid receptor agonist-5 | 2913231-72-6 | Glucocorticoid receptor agonist-5 (compound 4) is a glucocorticoid molecule and a potent glucocorticoid receptor agonist. |
|
V54474 | Gly-Cyclopropane-Exatecan | 2414254-49-0 | Gly-Cyclopropane-Exatecan (compound 5c) participates in the synthesis/preparation of anti-B7-H4 antibody active molecular conjugates (ADC), containing the DNA topoisomerase I (Top I) inhibitor Exatecan . |
|
V99943 | Gly-Gly-Phe-Gly-NH-O-CO-Exatecan | 1599440-12-6 | Gly-Gly-Phe-Gly-NH-O-CO-Exatecan is an ADC toxin. |
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