ADC cytotoxins, also referred to as payloads, are cytotoxic substances that cause the death of target cells in ADCs (antibody drug conjugates). A monoclonal antibody, a linker, and a cytotoxin are the components of an ADC, which is a targeted agent. The cytotoxin is the most crucial component because it determines how effective an ADC is at killing cancer cells.
Numerous cytotoxins, including calicheamicins, duocarmycins, pyrrolobenzodiazepines (PBDs), camptothecins, daunorubicins/doxorubicins, auristatins, and maytansinoids, are currently in use. Based on how they work, they can be classified as either DNA-damaging agents or tubulin inhibitors. Among them are DNA minor groove binders like Calicheamicins, Duocarmycins, and PBDs as well as topoisomerase inhibitors like Camptothecins and Daunorubicins/Doxorubicins, which damage DNA. Tubulin inhibitors include auristatins and maytansinoids. There are numerous conventional cytotoxic agents with comparable mechanisms of killing cancer cells that can also be used in the development of ADCs in addition to the listed cytotoxins.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V129656 | Auristatin S | 3028453-70-2 | Auristatin S is an Auristatin payload with potent antitumor activity. |
|
V84314 | AXC-666 | 313350-30-0 | |
|
V54477 | Azonafide-PEABA | 2752193-52-3 | Azonafide-PEABA is a cytotoxic active molecule. |
|
V92055 | Boc-NMeVal-Val-Dil-Dap | 1369426-99-2 | Boc-NMeVal-Val-Dil-Dap is a linker that can be used to synthesize ADC molecules. |
|
V88358 | BTK degrader-1 | 2377645-56-0 | BTK degrader-1 (compound 1) is a Bruton's tyrosine kinase (BTK) bifunctional degrader that can be conjugated to CD79b. |
|
V54465 | CC-885-CH2-PEG1-NH-CH3 | 2722698-03-3 | CC-885-CH2-PEG1-NH-CH3 is a new degrader that may be utilized to prepare new antibody degrader conjugated active molecules (AnDC). |
|
V88360 | CC-885-CH2-PEG1-NH-CH3 TFA | CC-885-CH2-PEG1-NH-CH3 TFA is a degrader that can be used to synthesize antibody-degrader conjugate active molecules (AnDC). | |
|
V54486 | Corixetan | 1952359-26-0 | Corixetan is a highly efficient thorium chelator that can effectively cooperate with Th-227 and has sufficient stability in the body. |
|
V85535 | Cy3.5 maleimide | ||
|
V54488 | Cyclopropaneacetamide-Exatecan | 2414254-36-5 | Cyclopropaneacetamide-Exatecan (Compound 2-A) is an ADC Cytotoxin and Exatecan analogue. |
|
V52197 | DC0-NH2 | 615538-51-7 | DC0-NH2 is the effect part of ADC, an analogue of DC1, with higher stability. |
|
V75891 | DC10SMe | 2649727-40-0 | DC10SMe is a DNA alkylating agent that may be utilized to prepare active antibody conjugate molecules (ADC). |
|
V54473 | Diacetyl Agrochelin | 247115-75-9 | Diacetyl Agrochelin is an acetyl analogue of Agrochelin, which is produced by fermentation of marine Agrobacterium species. |
|
V51221 | Dideoxy-amanitin | 58255-46-2 | α-Amanitin derivative; ADC cytotoxin |
|
V53381 | DM3 (Maytansinoid DM3) | 796073-54-6 | DM3 (Maytansinoid DM3) is a maytansine analog with a disulfide bond or thiol group, an inhibitor (blocker/antagonist) of tubulin, and a cytotoxic part of ADCs (antibody-drug conjugates). |
|
V54468 | DM3-SMe | 796073-70-6 | DM3-SMe is a maytansine analogue, a tubulin inhibitor, and the cytotoxic part of an antibody-drug-conjugate/ADC (ADCs), which can be inhibited through disulfide bonds or stable thioethers. |
|
V53022 | DM4-SMe | 796073-68-2 | DM4-SMe is a metabolite of antibody-maytansine conjugate (AMC), a tubulin inhibitor, and a cytotoxic part of antibody-drug-conjugates/ADCss (ADCs). |
|
V51212 | DMEA-PNU-159682 | 1799421-48-9 | cytotoxin for ADCs |
|
V51213 | DMEA-PNU-159682 dichloroacetate | 1799421-49-0 | cytotoxin for ADCs |
|
V99961 | Dov-Val-Dil-OH | 133120-89-5 | Dov-Val-Dil-OH is an ADC toxin. |
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