ADC Cytotoxin

ADC Cytotoxin

ADC cytotoxins, also referred to as payloads, are cytotoxic substances that cause the death of target cells in ADCs (antibody drug conjugates). A monoclonal antibody, a linker, and a cytotoxin are the components of an ADC, which is a targeted agent. The cytotoxin is the most crucial component because it determines how effective an ADC is at killing cancer cells.

Numerous cytotoxins, including calicheamicins, duocarmycins, pyrrolobenzodiazepines (PBDs), camptothecins, daunorubicins/doxorubicins, auristatins, and maytansinoids, are currently in use. Based on how they work, they can be classified as either DNA-damaging agents or tubulin inhibitors. Among them are DNA minor groove binders like Calicheamicins, Duocarmycins, and PBDs as well as topoisomerase inhibitors like Camptothecins and Daunorubicins/Doxorubicins, which damage DNA. Tubulin inhibitors include auristatins and maytansinoids. There are numerous conventional cytotoxic agents with comparable mechanisms of killing cancer cells that can also be used in the development of ADCs in addition to the listed cytotoxins.

ADC Cytotoxin related products

Structure Cat No. Product Name CAS No. Product Description
V54461 (rac)-Exatecan Intermediate 1 (4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-F]indolizine-3,6,10(4H)-trione ) 102978-40-5 (rac)-Exatecan Intermediate 1 is an isomer of Exatecan Intermediate 1.
V54462 (S)-Seco-Duocarmycin SA 152785-82-5 (S)-Seco-Duocarmycin SA is a DNA alkylating agent that works as the toxin part of the antibody active molecular conjugate (ADC cytotoxin).
V54471 17-AEP-GA 75747-23-8 17-AEP-GA is an HSP90 antagonist that effectively inhibits glioblastoma cell proliferation/growth, survival, migration and invasion.
V54478 17-GMB-APA-GA 256337-10-7 17-GMB-APA-GA is an ADC Cytotoxin.
V52521 2',3'-cGAMP-C2-SH 2133823-39-7 2',3'-cGAMP-C2-SH is an ADC Cytotoxin disclosed in patent US20210015941, Example 24.
V52959 7-Aminomethyl-10-methyl-11-fluorocamptothecin 2378616-23-8 7-Aminomethyl-10-methyl-11-fluoro camptothecin is the toxin molecule of MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin , which may be utilized to prepare camptothecin antibody conjugate drugs.
V77314 7-Aminomethyl-10-methyl-11-fluoro camptothecin TFA 7-Aminomethyl-10-methyl-11-fluoro camptothecin TFA is the toxin molecule of MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin, which may be utilized to prepare camptothecin antibody drug conjugates (ADC).
V54485 7-Hydroxyethyl carbamate-(10Me-11F-Camptothecin) 2873460-17-2 7-Hydroxyethyl carbamate-(10Me-11F-Camptothecin) is an analog of Camptothecin .
V54479 Ac-Exatecan 2922852-48-8 Ac-Exatecan is acetylated Exatecan .
V34722 Aeruginosin 865 1611990-01-2 Aeruginosin 865 was extracted from the terrestrial cyanobacteria Nostoc sp.
V53480 Agrochelin 247115-74-8 Agrochelin is an alkaloid cytotoxic antibiotic produced by fermentation of the marine Agrobacterium species.
V34676 Aldoxorubicin hydrochloride (INNO-206 hydrochloride; DOXO-EMCH hydrochloride) 1361563-03-2 Aldoxorubicin (INNO-206) HCl (is the albumin-bound precursor of doxorubicin (a DNA topoisomerase II inhibitor) and is released from albumin under acidic conditions.
V51973 Aminohexylgeldanamycin (AHGDM) 485395-71-9 Aminohexylgeldanamycin (AHGDM), an analogue of geldanamycin, is a heat shock protein 90 (HSP90) inhibitor.
V51974 Aminohexylgeldanamycin hydrochloride (AHGDM hydrochloride) 1146534-45-3 Aminohexylgeldanamycin (AHGDM) HCl, an analogue of Geldanamycin, is a heat shock protein 90 (HSP90) inhibitor.
V11901 Auristatin F 163768-50-1 Auristatin F is anMMAF analogused as a cytotoxin in ADC (Antibody-drug conjugates) synthesis, acting as highlypotent antimitotic agent/tubulin inhibitor and anticancer agent thatinhibits tubulin polymerization.
V54477 Azonafide-PEABA 2752193-52-3 Azonafide-PEABA is a cytotoxic active molecule.
V54465 CC-885-CH2-PEG1-NH-CH3 2722698-03-3 CC-885-CH2-PEG1-NH-CH3 is a new degrader that may be utilized to prepare new antibody degrader conjugated active molecules (AnDC).
V54486 Corixetan 1952359-26-0 Corixetan is a highly efficient thorium chelator that can effectively cooperate with Th-227 and has sufficient stability in the body.
V54488 Cyclopropaneacetamide-Exatecan 2414254-36-5 Cyclopropaneacetamide-Exatecan (Compound 2-A) is an ADC Cytotoxin and Exatecan analogue.
V52197 DC0-NH2 615538-51-7 DC0-NH2 is the effect part of ADC, an analogue of DC1, with higher stability.
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