AMPK (AMP-activated protein kinase) is an enzyme that plays a role in cellular energy homeostasis.It is made up of three proteins (subunits), which when combined form a useful enzyme. The overall result of AMPK activation is stimulation of skeletal muscle fatty acid oxidation and muscle glucose uptake by pancreatic beta-cells. This is offset by inhibition of cholesterol, lipogenesis, and triglyceride synthesis, inhibition of adipocyte lipolysis, and stimulation of hepatic fatty acid oxidation and ketogenesis. As a metabolic master switch, AMPK controls a number of intracellular processes, such as the uptake of glucose by cells, the -oxidation of fatty acids, and the GLUT4 and mitochondrial biogenesis.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V0246 | Dorsomorphin 2HCl (BML275) | 1219168-18-9 | Dorsomorphin 2HCl (formerly BML-275 dihydrochloride) is a reversible and selective AMPK (AMP-activated protein kinase) inhibitor thatinhibits AMPK with a Ki of 109 nM in cell-free assays, exhibiting little inhibition against closely related kinases such as ZAPK, SYK, PKCθ, PKA, and JAK3. |
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V12775 | Nilotinib HCl hydrate | 923288-90-8 | Nilotinib HCl hydrate (formerly also known asAMN-107, AMN107 HCl hydrate) is a potent, orally bioavailable aminopyrimidine-derivative Bcr-Abl inhibitor with IC50 less than 30 nM in Murine myeloid progenitor cells. |
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V0247 | Phenformin HCl (ST50409947; D08352; W104144) | 834-28-6 | Phenformin HCl (ST-50409947; D-08352; W-104144), the hydrochloride salt of phenformin, was a marketed anti-diabetic drug ofthe biguanide class, but was withdrawn from most markets in the late 1970s due to a high risk of lactic acidosis. |
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V6440 | Bempedoic acid (ESP55016; ETC1002) | 738606-46-7 | Bempedoic acid (formerly ESP-55016; ETC-1002; ESP55016; ETC1002;Nexletol;Bempedoate) is an ATP-citrate lyase (ACL) inhibitor as well as an activator of hepatic AMP-activated protein kinase (AMPK). |
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V21592 | Ginkgolide C (BN-52022) | 15291-76-6 | Ginkgolide C (BN-52022) is a naturally occuring product isolated from Ginko and a GABA-A receptor, α-1 GlyR, and PAF receptor antagonist. |
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V0245 | Acadesine (AICAR; NSC-105823) | 2627-69-2 | Acadesine (also known as NSC105823,AICA-riboside, and AICAR) is a novel and potent AMPK (AMP-activated protein kinase) activatorwith potential antitumor and antidiabetic activity. |
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V13330 | Marein | 535-96-6 | Marein has neuro-protective (neuro-protection) effects by reducing damage to mitochondrial function and activation of the AMPK signaling pathway. |
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