AMPK

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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AMPK

AMPK (AMP-activated protein kinase) is an enzyme that plays a role in cellular energy homeostasis.It is made up of three proteins (subunits), which when combined form a useful enzyme. The overall result of AMPK activation is stimulation of skeletal muscle fatty acid oxidation and muscle glucose uptake by pancreatic beta-cells. This is offset by inhibition of cholesterol, lipogenesis, and triglyceride synthesis, inhibition of adipocyte lipolysis, and stimulation of hepatic fatty acid oxidation and ketogenesis. As a metabolic master switch, AMPK controls a number of intracellular processes, such as the uptake of glucose by cells, the -oxidation of fatty acids, and the GLUT4 and mitochondrial biogenesis.

AMPK related products

Cat No.	Product Name	CAS No.	Product Description
V104936	LW1564	2668337-39-9	LW1564 is a HIF-1α inhibitor with IC50 of 1.2 µM in HepG2.
V55745	MARK-IN-4	1990492-86-8	MARK-IN-4 is a potent inhibitor of microtubule affinity-regulated kinase (MARK) with IC50 of 1 nM.
V76788	MARK4 inhibitor 2		MARK4 inhibitor 2 is an inhibitor (blocker/antagonist) of microtubule affinity-regulated kinase 4 (MARK4), with a Km value of 6.3×107 and IC50 of 0.82 μM.
V4058	MK-3903	1219737-12-8	MK-3903 (MK3903) is a novel, potent and selectiveAMPK (AMP-activated protein kinase)activator with EC50 of 8 nM for α1 β1 γ1 subunit,leading to improved lipid metabolism and insulin sensitization in mice.
V4287	MK8722	1394371-71-1	MK-8722 (MK8722) is a novel, potent allostericpan-AMPK activator with anti-diabetic effects.
V106234	MOTS-c (mouse)		MOTS-c (mouse) is a mitochondrial-derived polypeptide that regulates pancreatic cell function.
V33389	O-304	1261289-04-6	O-304 is a first-in-class, orally bioavailable pan-AMPK activator, which increases AMPK activity by suppressing the dephosphorylation of pAMPK.
V3110	PF-06409577	1467057-23-3	PF-06409577 (PF06409577) is a potent, selective, orally bioavailable, allosteric activator ofAMPKα1β1γ1 (5′ adenosine monophosphate-activated protein kinase) with the potential to be used for diabetic nephropathy.
V86088	PXL770	1523493-53-9
V88839	SIK-IN-1	3033846-29-3	SIK-IN-1 (Compound 53) is an inhibitor of salt-inducible kinase (SIK), inhibiting SKI1, SIK2, and SIK3 with IC50 of 0.1, 0.4, and 1.5 nM, respectively.
V88840	SIK-IN-2	3033846-20-4	SIK-IN-2 (Compound 45) is an inhibitor of salt-inducible kinase (SIK), inhibiting SKI1, SIK2 and SIK3 with IC50 of 0.1, 0.2 and 0.4 nM, respectively.
V88831	SIK-IN-3		SIK-IN-3 (Compound 6B) is an inhibitor of salt-inducible kinase (SIK), inhibiting SKI1, SIK2 and SIK3 with IC50 of 0.1, 0.3 and 0.8 nM, respectively.
V33400	TMPA	1258275-73-8	TMPA is a high-affinity Nur77 antagonist, and binding to Nur77 results in the release and shuttling of LKB1 in the cytoplasm to activate AMPKα.
V105003	UCB9386		UCB9386 is a brain-penetrant and selective Nuak1 inhibitor with a pIC50 of 10.1.
V0248	WZ4003	1214265-58-3	WZ4003 is a novel, potent and highly specific inhibitor of NUAK kinases.
V35098	ZLN024 hydrochloride	1883548-91-1	ZLN024 HCl is an AMPK allosteric activator.
V11178	Buformin	692-13-7	Buformin (NSC-528218; 1-butylbiguanide) is an orally bioavailableAMPKactivator approved for use as anantidiabetic drug.
V0251	Dorsomorphin (BML275)	866405-64-3	Dorsomorphin(BML-275) is a reversible and selective AMPK (AMP-activated protein kinase) inhibitor with a Ki of 109 nM in cell-free assays, exhibiting little effects against closely related kinases such as ZAPK, SYK, PKCθ, PKA, and JAK3.
V50991	Chamaejasmine	69618-96-8	Chamaejasmine is a biflavonoid that can be extracted from the root of Daphne wolfberry and has anti-tumor activity.
V16495	Buformin hydrochloride	1190-53-0	Buformin hydrochloride(NSC-528218; NSC528218;1-butylbiguanide) is an orally availableAMPKactivator used as anantidiabetic drug belonging to the biguanide class.