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AMPK

AMPK

AMPK (AMP-activated protein kinase) is an enzyme that plays a role in cellular energy homeostasis.It is made up of three proteins (subunits), which when combined form a useful enzyme. The overall result of AMPK activation is stimulation of skeletal muscle fatty acid oxidation and muscle glucose uptake by pancreatic beta-cells. This is offset by inhibition of cholesterol, lipogenesis, and triglyceride synthesis, inhibition of adipocyte lipolysis, and stimulation of hepatic fatty acid oxidation and ketogenesis. As a metabolic master switch, AMPK controls a number of intracellular processes, such as the uptake of glucose by cells, the -oxidation of fatty acids, and the GLUT4 and mitochondrial biogenesis.

AMPK related products

Structure Cat No. Product Name CAS No. Product Description
Biotin-AMPKα1β1γ2 Recombinant Human Active Protein Kinase V118886 Biotin-AMPKα1β1γ2 Recombinant Human Active Protein Kinase AMPK is an αβγ heterotrimeric serine/threonine kinase that can be activated by decreasing adenosine triphosphate (ATP) concentration and increasing AMP concentration.
Biotin-AMPKα1β2γ1 Recombinant Human Active Protein Kinase V118901 Biotin-AMPKα1β2γ1 Recombinant Human Active Protein Kinase AMPK is an αβγ heterotrimeric serine/threonine kinase that can be activated by decreasing adenosine triphosphate (ATP) concentration and increasing AMP concentration.
Biotin-AMPKα2β1γ1 Recombinant Human Active Protein Kinase V118940 Biotin-AMPKα2β1γ1 Recombinant Human Active Protein Kinase AMPK is an αβγ heterotrimeric serine/threonine kinase that can be activated by decreasing adenosine triphosphate (ATP) concentration and increasing AMP concentration.
Biotin-Nuak2 Recombinant Human Active Protein Kinase V117555 Biotin-Nuak2 Recombinant Human Active Protein Kinase Nuak2 is a member of the SNF1/AMP kinase (AMPK) family (serine/threonine kinases) and is regulated by the putative tumor suppressor LKB1 (20-23) and the death receptor signaling pathway via the NF-κB pathway.
Candidusin A V120236 Candidusin A 81474-59-1 Candiduxin A (CHNQD-0803) (compound 4) is an AMPK activator with a KD value of 47.28 nM.
CB1R/AMPK modulator 1 V78668 CB1R/AMPK modulator 1 2711012-08-5 CB1R/AMPK modulator 1 (Compound 38-S) is an orally bioactive CB1R/AMPK modulator with a Ki of 0.81 nM and a CB1R IC50 of 3.9 nM.
COH-SR4 V52231 COH-SR4 73439-19-7 COH-SR4 is an AMPK activator.
EGFR-IN-146 V134956 EGFR-IN-146 166039-38-9 EGFR-IN-146 is an EGFR inhibitor that inhibits the EGFR signaling pathway and improves insulin sensitivity by activating the AMPK pathway, thereby effectively reducing blood glucose levels and weight.
Ethyl (E)-ferulate V98107 Ethyl (E)-ferulate 28028-62-8 Ethyl (E)-ferulate is an activator of the AMPK/Nrf2 signaling pathway and can alleviate lipopolysaccharide-induced acute lung injury.
EX-229 V3967 EX-229 1219739-36-2 EX229 (EX-229; AMPK Activator 991), a benzimidazole analog, is a novel, potent and allosteric AMPK (AMP-activated protein kinase) activator with Kd values of 0.06 μM, 0.06 μM and 0.51 μM for α1β1γ1, α2β1γ1 and α1β2γ1 in biolayer interferometry, respectively.
FGFR4-IN-23 V135922 FGFR4-IN-23 FGFR4-IN-23 is an FGFR4 inhibitor with an IC50 value of 2.9 nM against FGFR4WT kinase.
Fluoxetine-Conjugated Platinum(IV) prodrug-1 V136161 Fluoxetine-Conjugated Platinum(IV) prodrug-1 Fluoxetine-Conjugated Platinum(IV) prodrug-1 is an eEF2K inhibitor.
FXR antagonist 4 V136431 FXR antagonist 4 FXR antagonist 4 is an orally effective selective FXR antagonist with an IC50 value of 0.70 μM.
Galbacin V136492 Galbacin 528-64-3 Galbacin is an epimer of (-)-Zuonin A (A) and is an AMPK activator.
GSK621 V0249 GSK621 1346607-05-3 GSK621 is a novel, potent and selective activator of AMP-activated protein kinase (AMPK) with potential antitumor activity.
HDAC11-IN-2 V137176 HDAC11-IN-2 2919766-97-3 HDAC11-IN-2 is a highly selective histone deacetylase 11 (HDAC11) inhibitor.
HSF1/AMPK activator 1 V137587 HSF1/AMPK activator 1 2170935-59-6 HSF1/AMPK activator 1 is a compound that can modulate the HSF1/AMPK axis and the TGF-β1/Smad signaling pathway.
HTH-01-015 V0250 HTH-01-015 1613724-42-7 HTH-01-015 is a novel, potent and selective inhibitor of NUAK1( (NUAK family SnF1-like kinase-1)which can serve as useful chemical probes to delineate the biological roles of the NUAK kinases.
HTH-02-006 V80316 HTH-02-006 HTH-02-006 is a NUAK2 inhibitor (IC50=126nM).
IND 1316 V84330 IND 1316 1888473-12-8
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