The mammalian nicotinamide adenine dinucleotide (NAD+) synthetic salvage pathway uses nicotinamide phosphoribosyltransferase (NAMPT) as the rate-limiting enzyme to catalyze the conversion of nicotinamide (NAM) and phosphoribosyl-pyrophosphates to nicotinamide mononucleotide (NMN). NAMPT is found in two different forms: extracellular (eNAMPT) and intracellular (iNAMPT).
Brown adipose tissue (BAT), liver, and kidney have high iNAMPT levels; white adipose tissue (WAT), lung, spleen, testes, and skeletal muscle have intermediate levels; and the brain and pancreas have undetectable iNAMPT levels. The release of eNAMPT into plasma, which is thought to result from post-translational modification of iNAMPT, is primarily caused by adipose tissue. There, it catalyzes the synthesis of NMN. Although eNAMPT has been reported to function as a cytokine with numerous roles in physiology and pathology, intracellular NAMPT is a key enzyme in controlling NAD metabolism. Cancer and other metabolic and inflammatory diseases have been linked to circulating eNAMPT.
Structure | Cat No. | Product Name | CAS No. | Product Description |
---|---|---|---|---|
V0961 | GMX1778 (CHS828) | 200484-11-3 | GMX1778 (GMX 1778;CHS828; GMX-1778;CHS-828) is a potent and selective/specific inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) with potential antitumor activity. | |
V0098 | GNE-617 | 1362154-70-8 | GNE-617 is a novel, potent and specific inhibitor NAMPT (nicotinamide phosphoribosyltransferase) that inhibits the biochemical activity of NAMPT with an IC50of 5 nM and exhibits efficacy in xenograft models of cancer. | |
V2814 | GNE-617 hydrochloride | 2070014-99-0 | GNE-617 hydrochloride is a specific inhibitor NAMPT (nicotinamide phosphoribosyltransferase) that inhibits the biochemical activity of NAMPT with an IC50of 5 nM and exhibits efficacy in xenograft models of cancer. | |
V72007 | GNE-617 hydrochloride | 2070014-99-0 | GNE-617 HCl is a specific NAMPT inhibitor that can suppress NAMPT activity with IC50 of 5 nM. | |
V51686 | LB-60-OF61 hydrochloride | 742064-38-6 | LB-60-OF61 HCl is a potent NAMPT inhibitor and LB-60-OF61 HCl is a cytotoxic compound selective for MYC-overexpressing cell lines. | |
V0959 | Manidipine (CV-4093) | 89226-50-6 | Manidipine (formerly CV-4093; CV 4093; CV4093), a calcium channel blocker (CCB) of the dihydropyridine class, is an approved drug that has been used clinically as an antihypertensive agent. | |
V51682 | Nampt activator-1 | 701929-65-9 | Nampt activator-1 (compound 1) is a potent activator of nicotinamide phosphotransferase (NAMPT) with EC50 of 3.3-3.7 μM. | |
V51683 | Nampt activator-2 | 2237268-90-3 | Nampt activator-2 (compound 34) is a potent NAMPT activator with EC50 of 0.023 μM. | |
V51680 | Nampt activator-3 | 2790481-63-7 | NAMPT activator-3 is a NAT mimetic and a NAMPT activator with EC50 of 2.6 μM and a KD of 132 nM. | |
V51681 | NAMPT degrader-3 | NAMPT degrader-3 (compound C5) is a NAMPT degrader that depends on VHL and proteasomal means. | ||
V80893 | Nampt-IN-10 trihydrochloride | Nampt-IN-10 tri HCl (compound 4) is an inhibitor (blocker/antagonist) of phosphoribosyltransferase (NAMPT). | ||
V51684 | NAMPT/IDO1-IN-1 | 2247884-06-4 | NAMPT/IDO1-IN-1 is a vascular wall-potent, two-fold inhibitor of NAMPT and IDO1 with IC50 of 57.5 nM and 233 nM, respectively. | |
V0960 | P7C3 | 301353-96-8 | P7C3 (P-7C3;P7 C-3;P 7C3) is a novel and potent proneurogenic and neuroprotective agent that acts by targeting the NAMPT (Nicotinamide phosphoribosyltransferase) enzyme. | |
V3144 | Padnarsertib (KPT-9274) | 1643913-93-2 | Padnarsertib (KPT-9274; KPT9274; PAK4-IN-1) is a potent, selective,orally bioavailablesmall molecule,non-competitive dual inhibitor of PAK4/NAMPT inhibitor with anticancer activity. | |
V3033 | STF-118804 | 894187-61-2 | STF-118804 is a highly specific and potent inhibitor of NAMPT (nicotinamide phosphoribosyl transferase) with IC50 values in the low nanomolar range. |