Leukotrienes, lipoxins, and neuroprotectins are just a few of the eicosanoids and docosanoids that are produced as a result of the metabolism of arachidonic and docosahexaenoic acid by the family of enzymes known as lipoxygenases (LOXs). These enzymes are either involved in oxidative stress and cell death mechanisms or in cell protection, depending on the redox state of the cells and other milieu conditions. Lipoxygenases are lipid peroxidizing enzymes that may be targets for pharmacological treatment because they are involved in the pathogenesis of inflammatory and hyperproliferative diseases.
According to where arachidonate is oxygenated, lipoxygenases are categorized as 5-, 8-, 9-, 11-, 12-, and 15-LOX. 5-LOX, 8-LOX, 12-LOX, and 15-LOX are the most prevalent animal LOXs, whereas 5-LOX and 15-LOX are the most prevalent plant LOXs. When it comes to the production of 5-hydroperoxyeicosatetraenoic acid (5-HpETE) and other bioactive lipid mediators, 5-LOX is the most prevalent isoform.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V73494 | (-)-Dihydroguaiaretic acid | 124649-78-1 | (-)-Dihydroguaiaretic acid is a lipoxygenase (Lipoxygenase) inhibitor and has anti-oxidant effect. |
|
V80079 | 12R-LOX-IN-2 | 12R-LOX-IN-2 (compound 7b) is an inhibitor (blocker/antagonist) of 12R-lipoxygenase (12R-LOX). | |
|
V73512 | 15-LOX-1 inhibitor 1 | 2349374-37-2 | 15-LOX-1 inhibitor 1 is a potent 15-lipoxygenase-1 (15-LOX-1) inhibitor (antagonist) with IC50 of 0.19 μM. |
|
V73492 | 2-TEDC | 132465-10-2 | 2-TEDC is a potent inhibitor of 5-, 12-, and 15-lipoxygenase with IC50s of 0.09 μM, 0.013 μM, and 0.5 μM, respectively. |
|
V73506 | 3-O-Acetyl-11-hydroxy-beta-boswellic acid (3α-O-acetyl-11α-hydroxy-beta-boswellic acid) | 146019-25-2 | 3-O-Acetyl-11-hydroxy-beta-boswellic acid is a 5-lipoxygenase (5-LO) inhibitor. |
|
V29713 | 4',5-Dihydroxyflavone | 6665-67-4 | 4',5-Dihydroxyflavone is a flavonoid analog acting as a soybean LOX-1 and yeast α-Glucosidase inhibitor, with an Ki of 102.6 μM for soybean LOX-1 and an IC50 of 66 μM for yeast α-glucosidase. |
|
V2326 | 4-MMPB | 928853-86-5 | 4-MMPB is a selective lipoxygenase 15-lipoxygenase inhibitor with an IC50 value of 18 μM. |
|
V73496 | 5,8,11-Eicosatriynoic acid (ETI) | 13488-22-7 | 5,8,11-Eicosatriynoic acid (ETI) is a lipoxygenase inhibitor that blocks the biosynthesis of LTC4 in mastocytoma cells. |
|
V9644 | 5-Demethylnobiletin | 2174-59-6 | 5-O-Demethylnobiletin (5-O-Norepinephrine), a polymethoxyflavonoid extracted from Citrus jambhiri Lush. |
|
V73493 | 5-LOX-IN-1 | 55040-82-9 | 5-LOX-IN-1 (compound 2b) is an inhibitor (blocker/antagonist) of 5-Lipoxygenase (5-LOX) with IC50 of 2.3 μM. |
|
V73497 | 5-LOX-IN-3 | 1875061-47-4 | 5-LOX-IN-3 (Compound 14) is a 5-Lipoxygenase inhibitor (IC50= <1 μM). |
|
V77660 | 5-LOX-IN-5 | 5-LOX-IN-5 (Compound 29) is a 5-LOX inhibitor (IC50= 56 nM). | |
|
V10619 | AKBA (Acetyl-11-keto-β-boswellic acid) | 67416-61-9 | AKBA,an active triterpenoid isolated from Boswellia serrate,is an antiangiogenic and neuroprotective agent as well asa novel Nrf2 activator. |
|
V73491 | ALOX15-IN-1 | 2764818-24-6 | ALOX15-IN-1 (compound 8b) is a potent and specific inhibitor of rabbit and human ALOX15 linoleate oxygenase activity against ALOX15 orthologs linoleic acid (LA) and arachidonic acid. |
|
V73503 | ALR-38 | 241127-61-7 | ALR-38 is a 5-lipoxygenase (5-LOX) inhibitor (IC50= 1.1 μM) with anti~inflammatory activity. |
|
V2309 | CAY10698 | 684236-01-9 | CAY10698 is a novel and potent 12-LOinhibitor ( IC50 =5.1 µM). |
|
V2397 | CDC lipoxygenase inhibitor | 132465-11-3 | Cinnamyl-3,4-dihydroxy-α-cyanocinnamate (CDC) is a potent 12/15 lipoxygenase (12/15-LO) inhibitor. |
|
V73495 | h15-LOX-2 inhibitor 1 | 478040-08-3 | h15-LOX-2 inhibitor 1 (Comp 105) is a human epithelial cell 15-lipoxygenase-2 (h15-LOX-2) inhibitor (antagonist) with IC50 of 0.34 μM. |
|
V73498 | KKII5 (4,6-diphenyl-1,2,3,4-tetracyanopyrimidine-2-sulfide) | 6381-55-1 | KKII5 is a potent lipoxygenase LOX-1 inhibitor (antagonist) with IC50 of 19 μM. |
|
V25654 | ML 351 | 847163-28-4 | ML351 is a potent and specific inhibitor of 15-LOX-1 with IC50 of 200 nM. |
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