The serine hydrolase family of enzymes includes the membrane-bound protein FAAH (Fatty Acid Amide Hydrolase).Numerous significant endogenous fatty acid amides, such as the putative anti-inflammatory compound palmitoylethanolamide (PEA) and the endogenous cannabimimetic anandamide (AEA), which induces sleep, are hydrolyzed by FAAH. A class of bioactive lipids known as fatty acid amides (FAAs) signaling is terminated by FAAH both in peripheral tissues and the central nervous system (CNS).
FAAH belongs to the amidase signature (AS) superfamily and is widely distributed in multicellular eukaryotes. FAAH has a key role in the control of the cannabinoid signaling, through the hydrolysis of the endocannabinoids anandamide and in some tissues 2-arachidonoylglycerol.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V71790 | AM 374 | 86855-26-7 | AM 374 is a fatty acid amide hydrolase (FAAH) inhibitor. |
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V4091 | BIA10-2474 | 1233855-46-3 | BIA 10-2474 is a novel, potent,long-acting and reversible inhibitor offatty acid amide hydrolase (FAAH)withIC50values of 50 to 70mg/kg in various rat brain regions. |
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V0909 | Biochanin A | 491-80-5 | Biochanin A (NSC-123538; Pratensol;NSC123538; olmelin; 4-Methylgenistein) is a novel,naturally occuring O-methylated isoflavone found inTrifolium pratense and Fabaceae plants such as clover, soy and alfalfa. |
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V71593 | CB2R/FAAH modulator-1 | 928892-60-8 | CB2R/FAAH modulator-1 is a full cannabinoid type 2 receptor (CB2R) agonist/activator with Ki of 14.8 nM and 241.3 nM for CB2R and CB1R, respectively. |
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V71589 | CB2R/FAAH modulator-2 | 2876918-68-0 | CB2R/FAAH modulator-2 (compound 26) is a dual-targeting modulator that works as a CB2R agonist and FAAH inhibitor. |
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V71600 | CB2R/FAAH modulator-3 | 2876918-67-9 | CB2R/FAAH modulator-3 (compound 27) is a dual-targeting modulator that works as a CB2R agonist and FAAH inhibitor. |
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V3293 | FAAH-IN-2 | 184475-71-6 | FAAH-IN-2 is a novel and potent FAAH (fatty acid amide hydrolase) inhibitor extracted from Patent WO/2008/100977A2. |
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V78760 | FAAH-IN-7 | FAAH-IN-7 is a reversible and potent inhibitor of FAAH with IC50 of 8.29 nM. | |
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V71797 | FAAH-IN-8 | 2867633-84-7 | FAAH-IN-8 is a competitive inhibitor of FAAH with IC50 of 6.7 nM and a Ki of 5 nM. |
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V71789 | FAAH/cPLA2α-IN-1 | 1696401-38-3 | FAAH/cPLA2α-IN-1 is a dual (bifunctional) inhibitor of FAAH and cPLA2α with IC50 of 32 and 47 nM respectively. |
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V71792 | FP-Biotin (FP-Biotin) | 259270-28-5 | FP-biotin is a potent organophosphorus poison and is suitable for the search for new biomarkers of organophosphorus poison exposure. |
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V71585 | Isopropyl dodec-11-enylfluorophosphonate (IDEFP) | 623114-64-7 | Isopropyl dodec-11-enylfluorophosphonate (IDEFP) is an organophosphate that can inhibit the central cannabinoid receptor (CB1) and inhibits FAAH with similar potency (IC 50 = 2 nM). |
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V0910 | JNJ-1661010 | 681136-29-8 | JNJ-1661010 (JNJ 1661010;Takeda-25;JNJ1661010;Takeda25),a piperazinyl phenyl urea compound, is a selective and reversible inhibitor of Fatty acid amide hydrolase/FAAH with important biological activity. |
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V4504 | JNJ-42165279 | 1346528-50-4 | JNJ-42165279 is a novel, potent,covalent and selective FAAH (fatty acid amide hydrolase) inhibitor with IC50 of 70 ± 8 nM and 313 ± 28 nM for hFAAH and rFAAH, respectively. |
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V71796 | JP104 | 887264-45-1 | JP104 is an aryl carbamate and an irreversible FAAH inhibitor (antagonist) with pIC50 of about 8. |
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V2822 | JZL195 | 1210004-12-8 | JZL195 is a potent, selective and efficacious dual FAAH/MAGL (fatty acid amide hydrolase/monoacylglycerol lipase) inhibitor with IC50 of 13 nM and 19 nM for mouse brain FAAH and MAGL respectively. |
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V4866 | LY2183240 | 874902-19-9 | LY2183240 is a novel, potent and highly potent inhibitor of FAAH (fatty acid amide hydrolase) and a blocker of anandamide uptake with IC50 of 270 pM. |
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V0908 | PF-3845 | 1196109-52-0 | PF-3845 (PF3845; PF 3845) is a novel, biaryl ether piperidine-based, selective and covalent/irreversible inhibitor of FAAH (fatty acid amide hydrolase) with anti-inflammatory, antidiarrheal and antinociceptive effects. |
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V4443 | Redafamdastat (PF-04457845) | 1020315-31-4 | PF-04457845 (PF04457845) is a novel, highly potent and selectiveFAAH (fatty acid amide hydrolase)inhibitor with the potential for mananing pain and other nervous system disorders. |
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V71793 | SSR411298 | 666860-59-9 | SSR411298 is an orally bioactive, selective and reversible inhibitor of fatty acid amide hydrolase (FAAH). |
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