Serine (Ser) proteases are enzymes that catalyze the hydrolysis of specific peptide bonds in their substrates, and one of the amino acids in the enzyme's active site is always a serine. The trypsin family and the subtilisin family are two families that have received particular attention in research. The process of blood clotting, protein digestion, cell signaling, inflammation, and protein processing are just a few of the numerous cellular and extracellular functions that serine proteases are essential for. A threonine residue is present in the active site of a family of proteolytic enzymes known as thronine (Thr) proteases. Although the catalytic subunits of the proteasome are the prototype members of this class of enzymes, the active site geometry and mechanism of acyltransferases were convergently evolved.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V71909 | GGACK | 65113-67-9 | GGACK (H-Glu-Gly-Arg-CMK) is an irreversible substrate-like inhibitor of the serine protease urokinase plasminogen activator (uPA). |
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V87725 | HG1 Toxin | HG1 Toxin is a peptide found in the venom of the scorpion Heterometrus fulvipes, which has the activity of inhibiting potassium channel Kv1.3. HG1 Toxin also has the activity of inhibiting trypsin (Ki=107 nM) and can be used in the study of autoimmune diseases. | |
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V71903 | HMB-Val-Ser-Leu-VE | 862891-04-1 | HMB-Val-Ser-Leu-VE is a prototype vinyl ester vinyl ester inhibitor. |
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V87727 | HTRA1-IN-1 | HTRA1-IN-1 (Compound 17) is a selective inhibitor of serine peptidase 1 (HTRA1) with IC50 of 13 nM. | |
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V73397 | Inclisiran (ALN-PCSsc) | 1639324-58-5 | Inclisiran (ALN-PCSsc) is a double-stranded small interfering RNA (siRNA) molecule that can inhibit PCSK-9 transcription. |
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V71859 | Irucalantide | 1631160-47-8 | Irucalantide is a kallikrein inhibitor. |
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V71863 | Lerodalcibep (LIB003) | 2250073-78-8 | Lerodalcibep (LIB003) is a recombinant fusion protein of PCSK9 binding domain (adnectin) and human serum albumin. |
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V5056 | LSP-249 | 1801253-04-2 | LSP-249 (example 35), information from patent WO2016011209A1, is an inhibitor (blocker/antagonist) of plasma kallikrein, utilized in study/research of angioedema, with EC50 of less than 100 nM. |
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V105415 | MASP-2-IN-1 | MASP-2-IN-1 (Compound 77) is an inhibitor of mannan-binding lectin-associated serine proteases (MASPs), inhibiting MASP2 and MASP3 with IC50 of 11.4 nM and 13.2 µM, respectively. | |
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V84518 | Matriptase-IN-2 free base | 1268874-08-3 | |
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V87728 | N-a-Tosyl-L-lysinyl-chloromethylketone hydrochloride | 4238-41-9 | Na-Tosyl-L-lysinyl-chloromethylketone hydrochloride (TLCK hydrochloride) is an irreversible serine protease inhibitor that inhibits trypsin and trypsin-like proteases by alkylating the histidine residues at the active site. |
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V71867 | N-Benzoyl-L-tyrosine p-nitroanilide (Bz-Try-pNA) | 6154-45-6 | N-Benzoyl-L-tyrosine p-nitroanilide is a chymotrypsin substrate. |
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V93821 | Nacresertib | 2629977-59-7 | Nacresertib is a serine/threonine kinase (Ser/Thr protease) inhibitor. |
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V71895 | NBI-961 | 2225902-98-5 | NBI-961 is a potent NEK2 inhibitor that can suppress proteasomal degradation. |
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V87399 | Neutrophil elastase inhibitor 1 | 1448314-31-5 | Neutrophil elastase inhibitor 1 (Compound 5b) is a competitive, pseudo-irreversible inhibitor of neutrophil elastase (neutrophil elastase) with an IC50 of 7 nM. |
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V70200 | NSC45586 | 739301-85-0 | NSC45586 is an inhibitor (blocker/antagonist) of PHLPP. |
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V94280 | Patamostat hydrochloride | 3031765-17-7 | Patamostat (E-3123) hydrochloride is a potent protease inhibitor. |
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V71896 | Patamostat mesylate (E-3123 mesylate) | 114568-32-0 | Patamostat (E-3123) mesylate is a potent protease inhibitor. |
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V71907 | PCSK9-IN-1 | 2730022-10-1 | PCSK9-IN-1 is a new effective cyclic peptide PCSK9 inhibitor (antagonist) with Ki of 1.46 nM. |
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V73403 | PCSK9-IN-10 | 368434-98-4 | PCSK9-IN-10 is a potent, orally bioactive PCSK9 inhibitor (antagonist) with IC50 of 6.4 µM. |
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