Serine (Ser) proteases are enzymes that catalyze the hydrolysis of specific peptide bonds in their substrates, and one of the amino acids in the enzyme's active site is always a serine. The trypsin family and the subtilisin family are two families that have received particular attention in research. The process of blood clotting, protein digestion, cell signaling, inflammation, and protein processing are just a few of the numerous cellular and extracellular functions that serine proteases are essential for. A threonine residue is present in the active site of a family of proteolytic enzymes known as thronine (Thr) proteases. Although the catalytic subunits of the proteasome are the prototype members of this class of enzymes, the active site geometry and mechanism of acyltransferases were convergently evolved.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V86537 | Bradykinin acetate | 6846-03-3 | Bradykinin acetate is a potent endothelium-dependent vasodilator that lowers blood pressure. |
|
V103851 | C3TD879 | 2850259-33-3 | C3TD879 is an inhibitor of citrulline kinase (CITK), an AGC family serine/threonine kinase that regulates cytokinesis. |
|
V101106 | CDKL2-IN-1 | 2471972-15-1 | CDK-IN-14 (Compound 9) is a potent and selective CDKL2 (cyclin-dependent kinase-like 2) inhibitor with IC50 of 460 nM. |
|
V71906 | Chymotrypsinogen | 9035-75-0 | Chymotrypsinogen is the inactive precursor of Chymotrypsin. |
|
V78879 | CRA-2059 hydrochloride | CRA-2059 HCl is a selective and specific tryptase inhibitor (antagonist) with Ki of 620 pM for recombinant human trypsin-β (rHTβ). | |
|
V77139 | CRA-2059 TFA | CRA-2059 is a selective and specific tryptase inhibitor (antagonist) with Ki of 620 pM for recombinant human trypsin-β (rHTβ). | |
|
V71894 | Dansyl-Glu-Gly-Arg-Chloromethylketone | 69024-84-6 | Dansyl-Glu-Gly-Arg-Chloromethylketone is a protease inhibitor that can suppress serine/threonine proteases. |
|
V97179 | Dansyl-Glu-Gly-Arg-Chloromethylketone TFA | Dansyl-Glu-Gly-Arg-Chloromethylketone TFA is a protease inhibitor that inhibits serine/threonine proteases. | |
|
V71911 | DCLK1-IN-2 | 2978517-43-8 | DCLK1-IN-2 (compound I-5) is a potent inhibitor of DCLK1 with IC50 of 171.3 nM. |
|
V84473 | DCLK1-IN-3 | ||
|
V84481 | DCLK1-IN-4 | ||
|
V87724 | DCLK1-IN-5 | 3028774-14-0 | DCLK1-IN-5 (Compound a24) is a DCLK1 inhibitor (IC50: 179.7 nM). |
|
V87726 | Debrisoquin hydroiodide | 1052540-65-4 | Debrisoquin (hydroiodide) is the hydrochloride form of Debrisoquin. |
|
V71876 | Dim16 | 2743448-32-8 | Dim16 is a dual PCSK9/HMG-CoAR inhibitor (antagonist) with IC50 of 19 nM for PCSK9. |
|
V71891 | Endoproteinase Glu-C (V8 protease; Glu-C) | 137010-42-5 | Endoproteinase GluC (V8 protease) is a serine protease. |
|
V83229 | Enlicitide chloride (MK-0616) | 2407527-16-4 | Enlicitide chloride (MK-0616) is a novel and orally bioactive cyclic peptide-based PCSK9 inhibitor |
|
V71912 | Enteropeptidase (TMPRSS15) | 9014-74-8 | Enteropeptidase (TMPRSS15) is a type II transmembrane serine protease and a physiological activator of trypsinogen. |
|
V71866 | Feniralstat | 2166320-76-7 | Feniralstat is a pyrazole analogue, a potent kallikrein inhibitor (antagonist) with IC50 of 6.7 nM for human plasma kallikrein (pKal). |
|
V71869 | Flizasertib (GDC-8264) | 2268739-68-8 | Flizasertib is a serine/threonine kinase inhibitor. |
|
V71893 | Fluorescent Substrate for Subtillsin | 147471-56-5 | Fluorescent Substrate for Subtillsin may be utilized to detect the enzyme activity of Subtillsin. |
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