Proteasome

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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Proteasome

Proteasomes are enormous protein complexes found in all eukaryotes, archaea, and some bacteria. They are found in the cytoplasm and nucleus of eukaryotes. The proteasome's primary job is to break down unwanted or damaged proteins through the process of proteolysis, which is a peptide bond-breaking chemical reaction. Proteases are enzymes that carry out these types of reactions.A key mechanism by which cells control the concentration of specific proteins and destroy improperly folded proteins includes proteasomes. When a protein is degraded, it produces peptides that are seven to eight amino acids long. These peptides can then be further broken down into amino acids and used to create new proteins. A tiny protein called ubiquitin marks proteins for degradation. The tagging process is sped up by ubiquitin ligases, an enzyme family. Once a protein has one ubiquitin molecule attached to it, other ligases know to attach more ubiquitin molecules. As a result, a polyubiquitin chain forms, which the proteasome binds to and uses to break down the tagged protein.

Proteasome related products

Cat No.	Product Name	CAS No.	Product Description
V73364	PD 151746	181765-30-0	PD151746 is a calpain inhibitor that can suppress u-calpain (Ki = 0.26 ± 0.03 μM) with 20 times higher selectivity than m-calpain (Ki = 5.33 ± 0.77μM).
V105968	Phepropeptin A	396729-23-0	Phepropeptin A is a microbial secondary metabolite and proteasome inhibitor with IC50 of 21 μg/mL.
V105969	Phepropeptin B	396729-24-1	Phepropeptin B is a microbial secondary metabolite and proteasome inhibitor with IC50 of 11 μg/mL.
V105970	Phepropeptin C	396729-25-2	Phepropeptin C is a microbial secondary metabolite and proteasome inhibitor with IC50 of 12.5 μg/mL.
V105971	Phepropeptin D	396729-26-3	Phepropeptin D is a microbial secondary metabolite and proteasome inhibitor with IC50 of 7.8 μg/mL.
V73374	Proteasome β2c/i-IN-1	2322333-75-3	Proteasome β2c/i-IN-1 (compound 37) is a subunit-selective inhibitor of the proteases β2c and β2i.
V73369	Proteasome-IN-5	1613134-34-1	Proteasome-IN-5 (compound 5) is a protease inhibitor.
V143418	Proteasome-IN-7		Proteasome-IN-7 is an epoxy ketone macrocyclic peptide proteasome inhibitor (IC50 value of 37.92 nM against the 20S proteasome ChT-L subunit).
V114748	Proteasome-IN-8	3097658-48-2	Proteasome inhibitor-1 (compound 130) is a proteasome inhibitor.
V143740	RA183	2649154-64-1	RA183 is a proteasome ligand that can be used to synthesize CAP-TAC (proteasome cap-targeted chimera), such as RAPRMT5.
V143741	RA183-CO-C6-NHCO-NH-Boc		RA183-CO-C6-NHCO-NH-Boc is a proteasome ligand-linker conjugate that can be used to synthesize CAP-TAC (proteasome cap-targeted chimera), such as RAPRMT5.
V143742	RA190-PEG1-NH2	2375455-68-6	RA190-PEG1-NH2 is a derivative of RA190 and is a proteasome ligand.
V143788	RAFKBP12	2375455-59-5	RAFKBP12 is a FKBP12 CAP-TAC (protease complex cap-targeted chimera) degrader.
V2175	RAMB4(PTP1B-IN-9)	145888-79-5	RAMB4 (PTP1B-IN-9) is a novel and potent ubiquitin-proteasome system (UPS)-stressor.
V143847	RAPRMT5	2721998-42-9	RAPRMT5 is a PRMT5 CAP-TAC (protease complex targeting chimera) degrader.
V81349	Sadopeptins A		Sadopeptins A is a naturally occurring compound extracted from Streptomyces sp.
V81350	Sadopeptins B		Sadopeptins B is a naturally occurring compound extracted from Streptomyces sp.
V73375	Suc-Ala-Ala-Pro-Phe-SBzl	80651-95-2	Suc-Ala-Ala-Pro-Phe-SBzl works as a substrate for rat intestinal mast cell protease (RMCP I), rat skeletal muscle mast cell protease (RMCP II), and chymotrypsin (Chymotrypsin) .
V145675	TCL1	875165-39-2	TCL1 is a selective non-covalent inhibitor that targets the Pru domain of the Rpn-13 subunit in the proteasome 19S regulatory particle (19S RP), with an IC50 value of approximately 26 μM.
V115395	TIR-199	1514925-83-7	TIR-199 is a novel, highly specific dual proteasome inhibitor that effectively inhibits the PSMB5 subunit of the constitutive proteasome and the PSMB8 subunit of the immunoproteasome.