The liver has a high activity of the serine protease prolyl endopeptidase (PREP), also known as prolyl oligopeptidase (POP), which can specifically hydrolyze the peptide bond of the carboxylterminus of the proline residue in the polypeptide chain. Prep may be involved in physiological and pathological processes like peptide maturation and degradation, inflammation, oxidative stress, autophagy, cell proliferation, and cancer, according to growing evidence.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V34288 | Oroxyloside | 36948-76-2 | Oroxyloside, also known asOroxylin A-7-O-β-D-glucuronide,is natural product of the flavonoid class. |
|
V73358 | PREP inhibitor-1 | 2760543-16-4 | PREP inhibitor-1 is a potent inhibitor of prolyl oligopeptidase (PREP) (IC50 < 1 nM). |
|
V4276 | SP-13786 (UAMC1110, FAP-IN-1) | 1448440-52-5 | SP-13786 (UAMC-1110,FAP-IN-1) is a novel, potent andhighlyselective inhibitor of fibroblast activation protein (FAP) withIC50of 3.2 nM; it also inhibits prolyl oligopeptidase (PREP) with anIC50of 1.8 μM. |
|
V73361 | Suc-Ala-Pro-pNA | 95632-46-5 | Suc-Ala-Pro-pNA is a bioactive peptide that could be utilized as a substrate to detect the activity and stability of prolyl endopeptidase (PEP). |
|
V73356 | Y-29794 oxalate | 146794-84-5 | Y-29794 oxalate is a selective, orally bioactive and BBB (blood-brain barrier) permeable (penetrable) non-peptide prolyl endopeptidase inhibitor. |
|
V73359 | Z-Pro-Pro-aldehyde-dimethyl acetal | 170116-63-9 | Z-Pro-Pro-aldehyde-dimethyl acetal is a potent inhibitor (IC50= 12 nM) of prolyl endopeptidase (PREP), a cytoplasmic serine endoprotease. |
|
V73362 | Z-Pro-Pro-CHO | 108708-25-4 | Z-Pro-Pro-CHO is a prolyl oligopeptidase inhibitor (IC50= 0.16 μM and 0.01 μM for human and Schistosoma mansoni prolyl oligopeptidase, respectively). |
|
V73360 | Z-Pro-prolinal (N-Benzyloxycarbonyl-L-prolyl-L-prolinal) | 88795-32-8 | Z-Pro-prolinal (N-Benzyloxycarbonyl-L-prolyl-L-prolinal) is a specific, orally bioactive prolyl oligopeptidase (PREP) inhibitor (antagonist) with IC50 of 0.4 nM for porcine PREP. |
|
V73357 | Z-Thioprolyl-Thiazolidine | 118059-38-4 | Z-Thioprolyl-Thiazolidine is a potent and specific prolyl endopeptidase inhibitor (antagonist) with Ki of 0.36 nM for bovine brain prolyl endopeptidase. |
|
V73363 | Z-Thioprolyl-Thioproline | 118059-40-8 | Z-Thioprolyl-Thioproline is a bovine brain prolyl endopeptidase (PEP) inhibitor (IC50=16 µM; Ki=37 µM). |
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