MMPs (Matrix metalloproteinases) are zinc-dependent endopeptidases.The metzincin superfamily of proteases, to which the MMPs belong, is a larger group of enzymes. MMPs can process a variety of bioactive molecules in addition to breaking down various extracellular matrix proteins. They have been linked to the inactivation of chemokines and cytokines as well as the cleavage of cell surface receptors and the release of apoptotic ligands.Additionally, it is believed that MMPs have a significant impact on the proliferation, migration, differentiation, angiogenesis, apoptosis, and host defense of cells. It is believed that MMP-2 and MMP-9 are crucial for metastasis. MMP-1 is regarded as being significant in osteoarthritis and rheumatoid arthritis. Recent research indicates that MMPs are actively involved in the pathogenesis of aortic aneurysms. The structural proteins of the aortic wall are degraded by excess MMPs. Acute and chronic cardiovascular diseases both exhibit dysregulation of the balance between MMPs and TIMPs.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V73224 | MMP Inhibitor II | 203915-59-7 | MMP Inhibitor II (compound 4e) is a potent, reversible pan-MMP inhibitor (antagonist) with IC50s of 24 nM, 18.4 nM, 30 nM and MMP-9 for MMP-1, MMP-3, MMP-7 and MMP-9 respectively. |
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V80514 | MMP-1-IN-1 | MMP-1-IN-1 (Compound 6) is a potent MMP-1 inhibitor (antagonist) with IC50 of 0.034 μM. | |
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V85800 | MMP-11-IN-1 | ||
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V73255 | MMP-13 Substrate | 1872435-02-3 | MMP-13 Substrate is a substrate for MMP-13. |
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V87614 | MMP-13 Substrate TFA | MMP-13 Substrate TFA is a substrate of MMP-13. | |
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V73238 | MMP-13-IN-1 | 2925249-49-4 | MMP-13-IN-1 is a potent and specific MMP-13 inhibitor (antagonist) with IC50 of 16 nM. |
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V73228 | MMP-2 Inhibitor I | 10335-69-0 | MMP-2 Inhibitor I (OA-Hy) is a potent MMP-2 inhibitor (antagonist) with Ki of 1.7 μM. |
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V73226 | MMP-2 Inhibitor II | 869577-51-5 | MMP-2 Inhibitor II (Compound 2) is a selective inhibitor. |
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V105172 | MMP-2 Inhibitor-4 | MMP-2 inhibitor-4 (Compound 5g) is a MMP-2 inhibitor with IC50 of 152.62 nM. | |
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V110756 | MMP-2/9-IN-2 | MMP-2/9-IN-2 (compound 6k) is an inhibitor of MMP-2 and MMP-9, with IC50 values of 29.27 μM and 24.87 μM, respectively. | |
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V73239 | MMP-7-IN-1 | 2865097-05-6 | MMP-7-IN-1 is a potent and specific inhibitor of MMP-7 (IC50=10 nM), with IC50> for MMP-1, -2, -3, -8, -9, -13 11mM. |
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V73229 | MMP-7-IN-2 | 2848717-49-5 | MMP-7-IN-2 (comp 16) is a selective inhibitor of MMP7 with IC50 of 16 nM. |
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V73242 | MMP-7-IN-3 | 2865097-58-9 | MMP-7-IN-3 is a potent selective inhibitor of MMP-7. |
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V73235 | MMP-8 inhibitor-1 (MMP8-I) | 236403-25-1 | MMP-8 inhibitor-1 (compound 21) is a hydroxamic acid analogue that is a potent MMP-8 inhibitor (antagonist) without significant oral bioavailability (F). |
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V73248 | MMP-8/MMP-26 Fluorogenic substrate | 135662-05-4 | MMP-8/MMP-26 Fluorogenic substrate (DNP-Pro-Leu-Ala-Tyr-Trp-Ala-Arg) is a fluorescent substrate for matrix metalloproteinase 8 (MMP-8). |
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V73249 | MMP-9-IN-6 | 2241964-36-1 | MMP-9-IN-6 (Compound 3g) is an MMP-9 inhibitor (antagonist) with IC50 of 50 μM and good anti-ulcer efficacy. |
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V73236 | MMP-9-IN-7 | 333746-76-2 | MMP-9-IN-7 is a potent MMP9 inhibitor (antagonist) with IC50 of 0.52 μM in proMMP9/MMP3 P126 activation assay. |
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V87610 | MMP-9-IN-9 | 206549-55-5 | MMP-9-IN-9 (compound 4f) is a selective MMP-9 inhibitor with IC50 of 5 nM. |
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V87619 | MMP-9/10-IN-1 | MMP-9/10-IN-1 (Compound 6b) is a potent dual MMP-9/10 inhibitor with IC50 of 0.076 and 0.139 μM for NSCLC and A549 cells, respectively. | |
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V83377 | MMP-9/10-IN-2 |
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