Mitochondria use multiple carbon fuels to produce ATP and metabolites, including pyruvate, which is generated from glycolysis; amino acids such as glutamine; and fatty acids. The reducing equivalents NADH and FADH2, which transfer their electrons to the electron transport chain, are produced by these carbon fuels by feeding into the TCA cycle in the mitochondrial matrix. Complex organelles called mitochondria are crucial for many aspects of cellular function, including metabolism, immune control, and cell death.Calcium buffering, lipid flux, and intracellular signaling are just a few of the many cellular processes and molecular interactions that mitochondria actively participate in. It is becoming more widely acknowledged that mitochondrial dysfunction is a defining feature of many diseases, including cancer, cardiovascular, and neurodegenerative conditions. Mitochondrial metabolism influences processes like the epithelial-to-mesenchymal transition, which is a key factor in the progression of tumors. The epigenetic landscape is altered by mitochondrial metabolism and the oncometabolites that result to change the aggressiveness characteristics of cancer cells. Regarding the survival of tumors in response to treatment, changes in mitochondrial metabolism are important.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V115737 | LY-266500 | 147104-27-6 | LY-266500 is a specific inhibitor of succinyl-CoA synthase (SCS). |
|
V73212 | Magmas-IN-1 | 1251957-89-7 | Magmas-IN-1 (compound 9) is a small molecule Magmas inhibitor (SMMI). |
|
V116473 | Malonyl CoA-13C3 lithium | Lithium malonyl-CoA-13C3 (Lithium malonyl-CoA-13C3) is a 13C-labeled lithium malonyl-CoA. | |
|
V73203 | Malonyl Coenzyme A lithium | 108347-84-8 | Malonyl Coenzyme A lithium is an inhibitor (blocker/antagonist) of carnitine palmitoyltransferase 1 (CPT1). |
|
V84780 | MCU-i11 | 902903-59-7 | |
|
V2300 | MCU-i4 | 371924-24-2 | MCU-i4 is a negative modulator ofof the MCU (mitochondrial calcium uniporter), acting by inhibitingIP3-dependent mitochondrial Ca2+-uptake and maintaining the gatekeeping role of their target. |
|
V85380 | ME-344 | 1374524-68-1 | |
|
V73205 | Menadiol (Dihydrovitamin K3) | 481-85-6 | Menadiol (Dihydrovitamin K3) is a menaquinone analog and an electron donor for reverse oxidative phosphorylation in submitochondrial granules. |
|
V114511 | MI-BP-CC | 2777017-18-0 | MI-BP-CC is a near-infrared fluorescent probe that targets mitochondria. |
|
V110952 | MitoBloCK-1 | 373370-73-1 | MitoBloCK-1 is an inhibitor that blocks substrate input by blocking the TIM22 transport pathway. |
|
V73199 | Mitochondrial fusion promoter M1 | 219315-22-7 | Mitochondrial fusion promoter M1 is a regulator of mitochondrial dynamics. |
|
V76764 | Mitochondrial respiration-IN-1 hydrobromide | Mitochondrial respiration-IN-1 HBr (compound 49) is a potent mitochondrial (mitochondrial) inhibitor (IC50=8.8 mg/mL), which can significantly reduce platelet mitochondrial respiration. | |
|
V80779 | Mitochondrial respiration-IN-3 | Mitochondrial respiration-IN-3 is a fluorine analogue of Dalfopristin. | |
|
V73217 | MitoTEMPO hydrate | 1569257-94-8 | Mito TEMPO is a mitochondria-targeted antioxidant with superoxide and alkyl radical scavenging properties. |
|
V98258 | MPC-IN-1 | MPC-IN-1 (compound 4i) is a cyanocinnamate-based mitochondrial pyruvate transporter (MPC) inhibitor and a derivative of UK-5099. | |
|
V73198 | MPP+ iodide | 36913-39-0 | MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes PD/Parkinson's disease symptoms in animal models by selectively destroying dopaminergic neurons in the substantia nigra. |
|
V87602 | MS-L6 | MS-L6 is a potent oxidative phosphorylation (OXPHOS) inhibitor that acts as an electron transport chain complex I (ETC-I) with a combined inhibition of NADH oxidation and uncoupling effects. | |
|
V108885 | Mycosporine glycine | 65318-21-0 | Mycosporin glycine (Mycosporin-Gly) is a potent singlet oxygen quencher. |
|
V87603 | Mycothiazole | 114582-75-1 | Mycothiazole is an inhibitor of complex I of the mitochondrial electron transport chain (ETC). |
|
V103284 | N-Propargylglycine | 58160-95-5 | N-Propargylglycine is an oral, irreversible proline dehydrogenase (PRODH) inhibitor. |
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