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MAGL

MAGL

Monoacylglycerol Lipase (MAGL) is a serine hydrolase that is essential in catalyzing the hydrolysis of monoglycerides into glycerol and fatty acids. By converting the plentiful endocannabinoid 2-arachidaoylglycerol into arachidonic acid, the precursor of prostaglandins and other inflammatory mediators, MAGL connects the endocannabinoid and eicosanoid systems.

MAGL is a key enzyme that regulates the levels of 2-AG, an important lipid with a variety of neuroprotective effects; ii) when MAGL is inactive, 2-AG levels in the brain are elevated and AA levels are decreased, which reduces the production of pro-inflammatory prostaglandins, which reduces neuroinflammation; and iii) MAGL controls the levels of free fatty acids (FFAs) in aggressive cancer cells, and this MAGL-promote MAGL is becoming a potentially effective drug target for a number of diseases.

MAGL related products

Structure Cat No. Product Name CAS No. Product Description
MAGL-IN-14 V87593 MAGL-IN-14 2770967-04-7 MAGL-IN-14 (compound 2) is a potent MAGL inhibitor with IC50 of 0.00289 μM and 0.002 μM in HEK293 and PC3, respectively.
MAGL-IN-15 V87592 MAGL-IN-15 2770967-08-1 MAGL-IN-15 (Compound 6) is a MAGL inhibitor that can be used to study diseases and conditions related to the modulation of endocannabinoid system signaling activity.
MAGL-IN-16 V87591 MAGL-IN-16 MAGL-IN-16 (compound 27) is an orally active, selective and reversible MAGL inhibitor with an IC50 of 10.3 nM.
MAGL-IN-17 V100264 MAGL-IN-17 1643657-35-5 MAGL-IN-17 (Compound) is an inhibitor of MAGL with Ki of 0.4 μM.
MAGL-IN-18 V97190 MAGL-IN-18 3036792-74-9 MAGL-IN-18 (Compound 118) is a potent inhibitor of monoacylglycerol lipase (MAGL) with IC50 of 0.03 nM.
MAGL-IN-19 V94907 MAGL-IN-19 2411570-42-6 MAGL-IN-19 (compound 7o) is a highly potent and selective MAGL inhibitor.
MAGL-IN-20 V104588 MAGL-IN-20 2607107-76-4 MAGL-IN-20 (Compound ± 34) is a reversible inhibitor of monoacylglycerol lipase (MAGL).
MAGL-IN-21 V139284 MAGL-IN-21 MAGL-IN-21 is a selective inhibitor of monoacylglycerol lipase (MAGL) with an IC50 of 1.59 nM.
MAGL-IN-4 V73515 MAGL-IN-4 2135785-20-3 MAGL-IN-4 is an orally bioactive, selective and reversible inhibitor of monoacylglycerol lipase (MAGL) with IC50 of 6.2 nM.
MAGL-IN-8 V78909 MAGL-IN-8 3017151-71-9 MAGL-IN-8 (compound 13) is a reversible inhibitor of monoacylglycerol lipase (MAGL) with IC50 of 2.5 ± 0.4 nM for hMAGL.
MAGL-IN-9 V79017 MAGL-IN-9 MAGL-IN-9 (compound 16) is a selective, reversible inhibitor of MAGL with IC50 of 2.7 nM.
MGL-IN-2 V117645 MGL-IN-2 1252773-92-4 MGL-IN-2 (compound 1) is an MGL inhibitor with an IC50 value of 0.006 μM against mutant MGL and 0.0121 μM against wild-type MGL.
ML-211 V73517 ML-211 2205032-89-7 ML-211 is a dual carbamate-based inhibitor of acyl protein thioesterase 1 (APT1)/lysophospholipase 1 (LYPLA1) (IC50=17 nM) and LYPLA2 (IC50=30 nM).
MS1262-C3-amide-C10-amine V140433 MS1262-C3-amide-C10-amine MS1262-C3-amide-C10-amine is an E3 ligase ligand-linker conjugate.
N-Arachidonyl maleimide V73518 N-Arachidonyl maleimide 876305-42-9 N-Arachidonyl maleimide is a potent, irreversible inhibitor of monoacylglycerol lipase (MAGL) with IC50 of 140 nM.
PROTAC MAGL degrader-1 V143361 PROTAC MAGL degrader-1 PROTAC MAGL degrader-1 is an orally effective PROTAC formulation that simultaneously targets monoacylglycerol lipase (MAGL) and E3 ubiquitin ligase MDM2.
WWL-123 V45847 WWL-123 1338575-41-9 WWL-123 is a novel, potent andselective ABHD6 inhibitor with antiepileptic effects.
WWL70 V17481 WWL70 947669-91-2 WWL-70 is a novel, potent inhibitor of α/β-hydrolase domain 6 (ABHD6) with IC50 of 70 nM.
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