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HIF HIF Prolyl-Hydroxylase

HIF HIF Prolyl-Hydroxylase

HIFs (Hypoxia-inducible factors) are transcription factors that react to variations in the amount of oxygen available to cells, more specifically, to reductions in oxygen, or hypoxia. The effects of hypoxia, a condition of low oxygen concentration, on the cell are mediated by the HIF signaling cascade. Oftentimes, hypoxia prevents cells from differentiating. However, hypoxia encourages the growth of blood vessels and is crucial for the development of a vascular system in both cancer tumors and embryos.Additionally, the hypoxia in wounds encourages keratinocyte migration and epithelium repair. HIFs are essential to development in general. HIF-1 gene deletion in mammals causes perinatal death. It has been demonstrated that HIF-1 is essential for chondrocyte survival and enables the cells to adapt to low oxygen environments in the growth plates of bones. Human metabolism is controlled in large part by HIF. A number of medications that function as selective HIF prolyl hydroxylase inhibitors have recently been created.

HIF HIF Prolyl-Hydroxylase related products

Structure Cat No. Product Name CAS No. Product Description
HIF-1α-IN-8 V119403 HIF-1α-IN-8 HIF-1α-IN-8 is an orally effective HIF-1α inhibitor with an IC50 value of 2.02 μM.
HIF-2α agonist 2 V51618 HIF-2α agonist 2 2750141-15-0 HIF-2α Agonist 2 (Compound 10) is a HIF-2α agonist/activator with EC50 of 1.68 μM at a dose of 20 μM.
HIF-2α agonist 3 V83427 HIF-2α agonist 3
HIF-2α-IN-10 V87492 HIF-2α-IN-10 3034532-74-3 HIF-2α-IN-10 (17) is a HIF-2α inhibitor with an IC50 value of 0.05 μM.
HIF-2α-IN-11 V87487 HIF-2α-IN-11 3034589-50-6 HIF-2α-IN-11 (1) is a HIF-2α inhibitor with IC50 of 59.2 nM.
HIF-2α-IN-12 V87489 HIF-2α-IN-12 3034488-33-7 HIF-2α-IN-12 (9) is a HIF-2α inhibitor with IC50 of 0.9 μM.
HIF-2α-IN-13 V87501 HIF-2α-IN-13 3034488-42-8 HIF-2α-IN-13 (18) is a HIF-2α inhibitor with IC50 of 2.7 μM.
HIF-2α-IN-14 V87497 HIF-2α-IN-14 3033981-37-9 HIF-2α-IN-14 (18) is an inhibitor of HIF-2α with an IC50 value of 0.27 μM.
HIF-2α-IN-15 V87499 HIF-2α-IN-15 3033981-70-0 HIF-2α-IN-15 (35) is an inhibitor of HIF-2α with an IC50 value of 0.41 μM.
HIF-2α-IN-16 V87486 HIF-2α-IN-16 3033981-97-1 HIF-2α-IN-16 (48) is an inhibitor of HIF-2α with an IC50 value of 0.091 μM.
HIF-2α-IN-8 V51617 HIF-2α-IN-8 2734922-78-0 HIF-2α-IN-8 is a potent HIF2α activator with epidermal activity.
HIF-2α-IN-9 V73838 HIF-2α-IN-9 2648334-36-3 HIF-2α-IN-9 (compound 35r) is an inhibitor (blocker/antagonist) of HIF-2α.
HIF-PHD-IN-1 V51619 HIF-PHD-IN-1 1567657-46-8 HIF-PHD-IN-1 is a dye for the hypoxia-inducible factor tyrosine kinase foam reflux platforming enzyme domain (HIF-PHD) with apoptosis pathway activity.
HIF-PHD-IN-3 V51620 HIF-PHD-IN-3 794582-71-1 HIF-PHD-IN-3 (compound 4) is an effective hiPSC-CM cardioprotective scaffold.
HIV-IN-7 V79795 HIV-IN-7 3032472-86-6 Axl-IN-16 (Compound 4) is an Axl inhibitor.
Imdatifan (HIF-2α-IN 7) V51615 Imdatifan (HIF-2α-IN-7) 2511247-29-1 Imdatifan (HIF-2α-IN-7) is a hypoxia-inducible factor 2α (HIF-2α) dye.
IOX2 sodium V51636 IOX2 sodium 2377239-85-3 IOX2 Sodium is an upper left pulsed styrene-dissolving enzyme-2 (PHD2) couple with IC50 of 22 nM.
ISM012-042 V105109 ISM012-042 ISM012-042 is an orally active PHD1 and PHD2 inhibitor with IC50 values of 1.9 and 2.5 nM, respectively.
Izilendustat V51629 Izilendustat 1303512-02-8 Izilendustat is a potent prolyl hydroxylase (prolyl hydroxylase) that stabilizes hypoxia-inducible factor-1 alpha (HIF-1α) and hypoxia-inducible factor-2 (HIF-2).
Izilendustat hydrochloride V51628 Izilendustat hydrochloride 1303513-80-5 Izilendustat (HCl) is a potent prolyl phosphatidylase (prolyl hydroxylase) that stabilizes hypoxia-inducible factor-1 alpha (HIF-1α) and hypoxia-inducible factor-2 (HIF-2 ).
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