A protein modifier called ubiquitin (UB) controls a variety of vital cellular functions. The E1 enzyme activates UB's C-terminal carboxylate to start the process of UB's transfer through the E1-E2-E3 cascade onto target proteins. The ubiquitin is attached to the E1 enzyme by a thioester bond during an ATP-dependent reaction, and this enzyme serves as the activating enzyme. The ubiquitin is transferred from the E1 enzyme to the conjugating E2 enzyme. The E3 enzyme, also known as the ubiquitin ligase, catalyzes the transfer of ubiquitin to the target protein (also known as the substrate) by forming an isopeptide bond.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V73088 | HB007 | 2387821-46-5 | HB007 is a small ubiquitin-related modifier 1 (SUMO1) degrader. |
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V88506 | Hdm2 E3 ligase inhibitor 1 | 414905-09-2 | Hdm2 E3 ligase inhibitor 1 (Compound 1) is a reversible inhibitor of Hdm2 (an E3 ubiquitin ligase)-mediated p53 protein ubiquitination with IC50 of 12.7 μM. |
|
V73097 | HECT E3-IN-1 | 1810058-52-6 | HECT E3-IN-1 (compound 3) is an inhibitor (blocker/antagonist) of HECT E3 ligase. |
|
V105050 | HGC652 | 3055558-98-7 | HGC652 is a molecular glue that targets the E3 ubiquitin ligase TRIM21, promotes the formation of a ternary complex between TRIM21 and NUP98, and induces the degradation of NUP155 and nuclear pore complex proteins, leading to cell death. |
|
V76922 | HOIPIN-8 | HOIPIN-8 is a potent inhibitor of linear ubiquitin chain assembly complex (LUBAC) with IC50 of 11 nM. | |
|
V120124 | JP-2-196 hydrochloride | JP-2-196 hydrochloride is a covalent molecular gel degrader that targets RNF126. | |
|
V115812 | MG Degrader 3 | 2413733-73-8 | MG Degrader 3 (compound CM-3) is a molecular gel degrader that targets CRBN protein. |
|
V116439 | ML-93 | 1858275-91-8 | ML-93 is an orally effective SAE inhibitor with an IC50 value of 0.4 μM. |
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V83672 | ML307 | ||
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V110750 | MRC37 | MRC37 is a highly efficient and selective small molecule ligand that can bind to the PRYSPRY domain of TRIM21. | |
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V110759 | MRT-31619 | MRT-31619 is a molecular gel degrader (MGD) targeting CRBN. | |
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V87395 | MS147 | MS147 is a VHL-based PROTAC PRC1 degrader. | |
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V87385 | MS181 | MS181 (compound 1) is a potent cereblon (CRBN)-recruiting and EED-binding polycomb repressive complex 1 (PRC1) PROTAC degrader. | |
|
V80899 | Navtemadlin-d7 (AMG 232-d7; KRT-232-d7) | Navtemadlin-d7 is the deuterated form of Navtemadlin. | |
|
V118509 | NSC20116 | 644-37-1 | NSC20116 is a uracil derivative that specifically targets the Set-and-Ring (SRA) domain of the oncogene UHRF1. |
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V116792 | Obudanersen | 2834724-31-9 | Obudanersen is an antisense oligonucleotide that targets and inhibits the expression of the UBE3A antisense transcript (UBE3A-AS) and has been used in studies of Angelman syndrome. |
|
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V116789 | Obudanersen sodium | Obudanersen sodium is an antisense oligonucleotide that targets and inhibits the expression of the UBE3A antisense transcript (UBE3A-AS) and has been used in studies of Angelman syndrome. | |
|
V88515 | p53-MDM2-IN-4 | 350678-63-6 | p53-MDM2-IN-4 (Example 4) is an inhibitor of p53-MDM2/X protein interaction with a Ki value of 3.079 μM. |
|
V104787 | Panepophenanthrin | 409064-57-9 | Permethrin is a compound isolated from the mushroom strain Panus rudis Fr. IFO 8994. |
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V85283 | PELI1-IN-1 |
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