Cytochrome p450 comprises a superfamily of heme-thiolate proteins named for the spectral absorbance peak of their carbon-monoxide-bound species at 450 nm. The p450 superfamily, which has members in every class of organisms, including Archaea, is thought to have descended from an ancestor gene that existed more than 3 billion years ago.One of the biggest multigene families has subsequently been created as a result of repeated gene duplications. These enzymes stand out for the variety of reactions they catalyze as well as the variety of chemically diverse substrates they act on. The oxidative, peroxidative, and reductive metabolism of endogenous and exogenous substrates like environmental toxins, agrochemicals, plant allelochemicals, steroids, prostaglandins, and fatty acids is supported by cytochrome p450s. Drug interactions and interindividual variability in drug metabolism are two of the most important issues in clinical pharmacology, and cytochrome p450s in humans are best known for their central role in phase I drug metabolism.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V73961 | 7-Ethoxyresorufin (7-ethoxyresorufin; Resorufin ethyl ether) | 5725-91-7 | 7-Ethoxyresorufin (Resorufin ethyl ether) is a fluorescent substrate and competitive inhibitor of cytochrome P450 (especially CYP1A1). |
|
V103325 | 7α-Hydroxy-DHEA | 53-00-9 | 7α-Hydroxy-DHEA (7α-Hydroxydehydroepiandrosterone) is the metabolite of DHEA catalyzed by intracellular steroid 7α-hydroxylase (such as P450 2A1). |
|
V70676 | 8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate | 67667-71-4 | 8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate is an irreversible CYP2A6 inhibitor (antagonist) with IC50 of 8.64 μM and 22.3 μM for preincubation and co-incubation, respectively. |
|
V73946 | Abiraterone-d4 (CB-7598-d4) | 2122245-62-7 | Abiraterone-d4 is the deuterated form of Abiraterone. |
|
V128311 | Adenosine receptor antagonist 6 | 2913578-04-6 | Adenosine receptor antagonist 6 is an orally effective selective A2A adenosine receptor (A2AAR) antagonist with a Ki value of 19.18 nM. |
|
V77872 | Anticancer agent 111 | Anticancer agent 111 (compound 11) is a potent cytochrome P450 inhibitor (antagonist) with IC50 of 3 μM for CYP3A4. | |
|
V128982 | Anticancer agent 310 | Anticancer agent 310 is an anti-tumor drug. | |
|
V128990 | Anticancer agent 318 | 2482789-24-0 | Anticancer agent 318 is a selective anticancer agent. |
|
V96752 | Antifungal agent 114 | Antifungal agent 114 (compound 19g) is an inhibitor of cytochrome P450 and inhibits CYP2C9, CYP2C19, CYP2D6, and CYP3A4 at a concentration of 10 μM. | |
|
V93407 | Antifungal agent 122 | 3054212-80-2 | Antifungal agent 122 (compound 201) is a potent broad-spectrum antifungal agent. |
|
V117520 | Antifungal agent 137 | 3032062-22-6 | Antifungal agent 137 (compound 4S) is an antifungal agent. |
|
V89561 | Antiproliferative agent-53-d3 | 2923508-77-2 | Antiproliferative agent-53-d3 (Compound C1) is an inhibitor of theta-mediated end joining (TMEJ) in HEK293 cells with IC50 of 0.14 µM. |
|
V73967 | Antitumor agent-87 | 1422527-88-5 | Antitumor agent-87 is a potent antitumor agent. |
|
V73965 | Antitumor agent-88 | 1422527-87-4 | Antitumor agent-88 displays potent antimitotic activity and arrests cells in the G2/M phase. |
|
V129238 | Apigenin-13C | Apigenin-13C is apigenin with a 13C label. | |
|
V129418 | Aripiprazole impurity 38 | 30389-33-4 | Aripiprazole impurity 38 is a compound associated with carteolol. |
|
V129454 | Aromatase-IN-1 | 331684-05-0 | Aromatase-IN-1 is a competitive aromatase (P450arom) inhibitor with a human IC50 value of 40 nM and a Ki value of 1.05 nM. |
|
V84866 | Aromatase-IN-3 | ||
|
V105099 | Aromatase-IN-4 | 3060588-16-8 | Aromatase-IN-4 (compound 6a) is an aromatase inhibitor. |
|
V129455 | Aromatase-IN-5 | Aromatase-IN-5 is a potent aromatase inhibitor with an IC50 value of 0.06 μM. |
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