Cytochrome p450 comprises a superfamily of heme-thiolate proteins named for the spectral absorbance peak of their carbon-monoxide-bound species at 450 nm. The p450 superfamily, which has members in every class of organisms, including Archaea, is thought to have descended from an ancestor gene that existed more than 3 billion years ago.One of the biggest multigene families has subsequently been created as a result of repeated gene duplications. These enzymes stand out for the variety of reactions they catalyze as well as the variety of chemically diverse substrates they act on. The oxidative, peroxidative, and reductive metabolism of endogenous and exogenous substrates like environmental toxins, agrochemicals, plant allelochemicals, steroids, prostaglandins, and fatty acids is supported by cytochrome p450s. Drug interactions and interindividual variability in drug metabolism are two of the most important issues in clinical pharmacology, and cytochrome p450s in humans are best known for their central role in phase I drug metabolism.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V124767 | 2-Methoxy-5-acetoxyfuranogermacr-1(10)-en-6-one | 75412-96-3 | 2-Methoxy-5-acetoxyfuranogermacr-1(10)-en-6-one is an aromatase (CYP19) inhibitor with an IC50 value of 0.21 μM for human targets. |
|
V112176 | 2-Pentylbenzimidazole | 5851-46-7 | 2-Pentylbenzimidazole (compound 10f) is a benzimidazole derivative and an inhibitor of aminopyrine N-demethylase, with a pIC50 value of 4.3. |
|
V124338 | 20-HETE IN-3 | 3119850-82-4 | 20-HETE IN-3 is an orally bioavailable 20-HETE synthesis inhibitor. |
|
V73948 | 20-HETE inhibitor-1 | 2472030-28-5 | 20-HETE inhibitor-1 (comp 83) is an inhibitor (blocker/antagonist) of 20-HETE synthesis. |
|
V111715 | 3,4-Methylenedioxyphenmetrazine hydrochloride | 3,4-Methylenedioxybenzomorpholine (3,4-MDPM) hydrochloride is a psychoactive substance. | |
|
V21477 | Galangin | 548-83-4 | Galangin (Norizalpinin) is a modulator of arylhydrocarbon receptors and inhibits CYP1A1 activity. |
|
V113211 | 3-Methylbenzofuran | 21535-97-7 | 3-Methylbenzofuran is a cytochrome P450 CYP2A6 inhibitor with an IC50 value of 7.35 μM. |
|
V112293 | 3-Methylquinoline | 612-58-8 | 3-Methylquinoline is a selective cytochrome P450 (CYP1A2) inhibitor with an IC50 value of 13 μM. |
|
V9500 | 3-CETC | 117620-77-6 | 3-CETC (3-Cyano-7-ethoxycoumarin) is a novel and potent fluorescent CYP1A1 &1A2 substrate. |
|
V73963 | 4,5-Dimethoxycanthin-6-one | 18110-87-7 | 4,5-Dimethoxycanthin-6-one is a potent, noncompetitive inhibitor of CYP1A2-mediated phenacetin O-deethylation with IC50 of 1.7 μM and a Ki of 2.6 μM. |
|
V107217 | 4,8-Dioxa-3H-perfluorononanoic acid | 919005-14-4 | 4,8-Dioxa-3H-perfluorononanoic acid is a per- and polyfluoroalkyl substance (PFAS) with affinity and potential agonist activity for human pregnane X receptor (hPXR). |
|
V114342 | 4-Ipomeanol | 32954-58-8 | 4-Isosorbide is a pulmonary toxin. |
|
V102736 | 4-Phenyl-1,2,3-thiadiazole | 25445-77-6 | 4-Phenyl-1,2,3-thiadiazole is an inhibitor of CYP2B4 and CYP2E1. |
|
V2677 | Fomepizole | 7554-65-6 | Fomepizole (also known as4-methylpyrazole, Antizol, Antizol-Vet)is a competitive inhibitor of alcohol dehydrogenase, an enzyme that catalyzes the initial steps in the metabolism of ethylene glycol,ethanol and methanol to their toxic metabolites. |
|
V73979 | 5,7,2',6'-Tetrahydroxyflavone | 82475-00-1 | 5,7,2',6'-Tetrahydroxyflavone is a naturally occurring flavonoid that can inhibit hepatic testosterone 6β-hydroxylation (CYP3A4) activity with IC50 of 7.8 μM. |
|
V106602 | 5-Methylchrysene | 3697-24-3 | 5-Methylrefractory can be activated by several isozymes of cytochrome P450 to form mutagenic metabolites. |
|
V127211 | 5α-Androst-2-en-17-one | 963-75-7 | 5α-Androst-2-en-17-one is a steroidal compound and an aromatase inhibitor. |
|
V73981 | 6',7'-Dihydroxybergamottin (6',7'-DHB) | 145414-76-2 | 6',7'-Dihydroxybergamomottin (6',7'-DHB) is a furanocoumarin that can inhibit CYP3A4 and is present in grapefruit juice and Seville orange juice. |
|
V127434 | 6-Methylchrysene | 1705-85-7 | 6-Methylchrysene is a weak carcinogen. |
|
V73957 | 7-Benzyloxy-4-(trifluoromethyl)coumarin (7-BFC) | 220001-53-6 | 7-Benzyloxy-4-(trifluoromethyl)coumarin (7-BFC) is a coumarin fluorescent substrate. |
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