Cytochrome P450

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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Cytochrome P450

Cytochrome p450 comprises a superfamily of heme-thiolate proteins named for the spectral absorbance peak of their carbon-monoxide-bound species at 450 nm. The p450 superfamily, which has members in every class of organisms, including Archaea, is thought to have descended from an ancestor gene that existed more than 3 billion years ago.One of the biggest multigene families has subsequently been created as a result of repeated gene duplications. These enzymes stand out for the variety of reactions they catalyze as well as the variety of chemically diverse substrates they act on. The oxidative, peroxidative, and reductive metabolism of endogenous and exogenous substrates like environmental toxins, agrochemicals, plant allelochemicals, steroids, prostaglandins, and fatty acids is supported by cytochrome p450s. Drug interactions and interindividual variability in drug metabolism are two of the most important issues in clinical pharmacology, and cytochrome p450s in humans are best known for their central role in phase I drug metabolism.

Cytochrome P450 related products

Cat No.	Product Name	CAS No.	Product Description
V115915	SCYX-6759	1222509-12-7	SCYX-6759 is an orally effective antitrypsy drug that can cross the blood-brain barrier.
V119345	CYP1B1-IN-10	2785358-47-4	CYP1B1-IN-10 (compound 15C) is a highly selective inhibitor of human cytochrome P450 1B1 (hCYP1B1) (IC50 = 0.11 μM).
V115765	CYP51-IN-28		CYP51-IN-28 (compound B9) is a CYP51 inhibitor.
V115749	CYP51-IN-29		CYP51-IN-29 (compound B3) is a CYP51 inhibitor and antifungal agent.
V109765	Fomepizole-d2		Deuterated formpyrazole (4-methylpyrazole-d2) is the deuterated form of formpyrazole.
V111120	CYP11A1-IN-2	3057862-18-4	CYP11A1-IN-2 (compound 61) is a selective cholesterol side-chain cleavage enzyme (CYP11A1) inhibitor.
V111309	Gamma-heptalactone	105-21-5	γ-Hemprolactone (γ-Hemprolactone) is a selective cytochrome P450 2B6 (CYP2B6) inhibitor with an IC50 value of 2400 μM.
V111547	(R)-N-3-Benzylnirvanol	790676-41-4	(R)-N-3-benzylniervano is the R-isomer of (±)-N-3-benzylniervano.
V111813	(R)-Esomeprazole	119141-89-8	(R)-Esomeprazole ((R)-Omeprazole; (+)-Omeprazole) is an orally effective regulator of cytochrome P450 (C450) 2C19, CYP3A4 and CYP2C9-related metabolic processes.
V111715	3,4-Methylenedioxyphenmetrazine hydrochloride		3,4-Methylenedioxybenzomorpholine (3,4-MDPM) hydrochloride is a psychoactive substance.
V111714	Butylcyclohexane	1678-93-9	n-Butylcyclohexane is a potent CYP2A6 inhibitor with an IC50 value of 43 μM.
V112003	(S)-Aminoglutethimide	57288-03-6	(S)-Aminoglutate is an aromatase inhibitor.
V112176	2-Pentylbenzimidazole	5851-46-7	2-Pentylbenzimidazole (compound 10f) is a benzimidazole derivative and an inhibitor of aminopyrine N-demethylase, with a pIC50 value of 4.3.
V112193	γ-Dodecanolactone	2305-05-7	γ-Dodecanolide is a γ-lactone compound.
V116275	E-2101	265667-22-9	E-2101 is a novel antispasmodic.
V73938	(3S,5S)-Atorvastatin sodium salt (Atorvastatin impurity sodium salt)	1428118-38-0	(3S,5S)-Atorvastatin sodium salt is a pregnane X receptor (PXR) activator and the inactive enantiomer of Atorvastatin.
V20588	ent-Atorvastatin	501121-34-2	ent-Atorvastatin [(3S,5S)-Atorvastatin] is an inactive isomer/enantiomer of Atorvastatin, which is a HMGCR (HMG-CoA reductase) inhibitor and an approved blockbuster drug of the statin class of LDL cholesterol-lowering/hypolipidemic drug.
V89626	(E/Z)-DMU2139	104890-70-2	(E/Z)-DMU2139 (Compound 180) is the E/Z isomer of DMU2139.
V86130	(R)-(+)-Aminoglutethimide L-Tartrate (d-Aminoglutethimide L-Tartrate)	57344-88-4
V73959	(R)-6',7'-Dihydroxybergamottin ((R)-6',7'-DHB)	264234-05-1	(R)-6',7'-Dihydroxybergamomottin ((R)-6',7'-DHB) is a competitive inhibitor of human and rat CYP1A1 activity, with Kis of 55 μM and 1.72 μM, respectively.