By making blood vessels tighten, the angiotensin-converting enzyme (ACE) indirectly raises blood pressure. Angiotensin I is changed by ACE into angiotensin II, which tightens the blood vessels. The renin-angiotensin system (RAS), which controls blood pressure by regulating the volume of fluids in the body, is made up of ACE, angiotensin I, and angiotensin II. Cells in the endothelium (inner layer) of blood vessels secrete ACE in the lungs and kidneys. It serves two main purposes: In a substrate concentration-dependent manner, ACE catalyzes the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor.Bradykinin, a potent vasodilator, and other vasoactive peptides are broken down by ACE. In order to treat conditions like high blood pressure, heart failure, diabetic nephropathy, and type 2 diabetes mellitus, ACE inhibition is a goal. Angiotensin II production and bradykinin metabolism are both reduced when ACE is inhibited (by ACE inhibitors), which results in a general dilation of the arteries and veins and a reduction in arterial blood pressure.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V72996 | (R)-MLN-4760 | 305335-29-9 | (R)-MLN-4760, the less active R-isomer of MLN-4760, is an ACE2 inhibitor (antagonist) with IC50 of 8.4 μM. |
|
V73020 | [Tyr6]-Angiotensin II | 52634-95-4 | [Tyr6]-Angiotensin II is a bioactive peptide fragment that binds to angiotensin converting enzyme 2. |
|
V73001 | Abz-Ser-Pro-3-nitro-Tyr | 553644-01-2 | Abz-Ser-Pro-3-nitro-Tyr is a substrate of ACE2 (ACE (angiotensin-converting enzyme)-2). |
|
V2463 | Acetyl tetrapeptide-5 | 820959-17-9 | Acetyl tetrapeptide-5 inhibits glycosylation and ACE-1 activity. |
|
V72998 | Bradykinin potentiator B (Bradykinin potentiating peptide B) | 30892-86-5 | Bradykinin potentiator B is the venom of Agkistrodon halys blomhoffi. |
|
V73012 | Camellianin B (Camellia flavonoid glycoside B) | 109232-76-0 | Camellianin B, a flavonoid, is a metabolite of Camellianin A. |
|
V73006 | Delapril-d3 hydrochloride (delapril hydrochloride d3 (hydrochloride)) | 2714473-25-1 | Delapril-d3 ( HCl) is the deuterated form of Delapril HCl. |
|
V72992 | DX600 | 478188-26-0 | DX600 is a selective ACE2-specific inhibitor (KD: 1.3 nM) that does not cross-react with ACE. |
|
V72997 | Enalaprilat-d5 (Enalaprilat D5; MK-422 d5) | 349554-00-3 | Enalaprilat-d5 is the deuterium labelled form of Enalaprilat. |
|
V73005 | FA-Phe-Phe | 83661-95-4 | FA-Phe-Phe is a furanoyl acryloyl (fa)-amino acid (AA) analogue that targets angiotensin-converting enzyme (ACE). |
|
V73016 | Ganoderic acid K | 104700-95-0 | Ganoderic acid K is a potent ACE (angiotensin-converting enzyme) inhibitor. |
|
V72993 | H-Ile-Pro-Pro-OH hydrochloride | 1208862-61-6 | H-Ile-Pro-Pro-OH HCl is a milk-derived tripeptide that can inhibit ACE (angiotensin-converting enzyme) with IC50 of 5 μM. |
|
V73011 | H-Lys-Trp-OH | 50674-18-5 | H-Lys-Trp-OH (KW) is an ACE inhibitory peptide with IC50 of 7.8 μM. |
|
V73017 | H-Pro-Phe-OH | 13589-02-1 | H-Pro-Phe-OH is a proline- and phenylalanine-containing dipeptide that serves as a substrate for prolinase. |
|
V73009 | H-Trp-Phe-OH | 6686-02-8 | H-Trp-Phe-OH is a dipeptide consisting of tryptophan and phenylalanine (Trp-Phe). |
|
V73015 | H-Tyr-Lys-OH | 54925-88-1 | H-Tyr-Lys-OH is a dipeptide that could be utilized as a biomarker for AJH-1. |
|
V73004 | Imidapril-d3 hydrochloride (Imidapril d3 hydrochloride) | 1356017-30-5 | Imidapril-d3 ( HCl) is the deuterium labelled form of Imidapril HCl. |
|
V73014 | Isocrenatoside | 221895-09-6 | Isocrenatoside (compound 6) is a cyclic octapeptide and an inhibitor (blocker/antagonist) of angiotensin-converting enzyme (ACE). |
|
V73013 | Isomartynoside | 94410-22-7 | Isomartynoside is a potent angiotensin-converting enzyme (ACE) inhibitor (antagonist) with IC50 of 505.9 µM. |
|
V72990 | L-Isoleucyl-L-arginine | 55715-01-0 | L-Isoleucyl-L-arginine is a dipeptide formed from L-isoleucine and L-arginine residues. |
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