A group of proteins known as toll-like receptors (TLRs) are essential components of the innate immune system. They are single, membrane-spanning, non-catalytic receptors that recognize structurally conserved molecules derived from microbes and are typically expressed in sentinel cells like macrophages and dendritic cells. Once these microbes have gotten past physical barriers like the skin or mucosa of the gastrointestinal tract, TLRs recognize them and trigger immune cell responses.
TLR1 through TLR13 are among the TLRs, along with TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TLR10, TLR11, TLR12, and TLR13. Toll-Like Receptors (TLRs) are involved in both the detection of endogenous danger signals and the early innate immune response to encroaching pathogens. TLRs are homologs of the Drosophila Toll protein, which was found to be crucial for defense against microbial infection. They are evolutionarily conserved receptors. TLRs identify pathogen-associated microbial patterns (PAMPs), which are only expressed by microbial pathogens and are highly conserved structural motifs.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V101091 | FAM-labeled ODN 1826 sodium | FAM-labeled ODN 1826 sodium is a class B CpG ODN and a TLR9 agonist. | |
|
|
V79421 | FITC-labeled Agatolimod sodium | FITC-labeled Agatolimod (sodium) is a class B CpG ODN and a TLR9 agonist. | |
|
|
V77015 | FITC-labeled ODN 1018 sodium | FITC-labeled ODN 1018 (sodium) is a TLR9 agonist. | |
|
|
V79422 | FITC-labeled ODN 1585 sodium | FITC-labeled ODN 1585 (sodium) is a class B CpG ODN and a TLR9 agonist. | |
|
|
V79423 | FITC-labeled ODN 1668 sodium | FITC-labeled ODN 1668 (sodium) is a class B CpG ODN and a TLR9 agonist. | |
|
|
V79424 | FITC-labeled ODN 1826 sodium | FITC-labeled ODN 1826 (sodium) is a class B CpG ODN and a TLR9 agonist. | |
|
|
V79425 | FITC-labeled ODN 2088 sodium | FITC-labeled ODN 2088 (sodium) is a TLR3, TLR7 and TLR9 inhibitor. | |
|
|
V77014 | FITC-labeled ODN 2216 sodium | FITC-labeled ODN 2216 (sodium) is a TLR9 agonist. | |
|
|
V79426 | FITC-labeled ODN 2395 sodium | FITC-labeled ODN 2395 (sodium) is a class C CpG ODN and a TLR9 agonist. | |
|
|
V79427 | FITC-labeled ODN TTAGGG sodium | FITC-labeled ODN TTAGGG (sodium) is an inhibitor oligonucleotide that is an antagonist of TLR9, AIM2 and cGAS. | |
|
V119766 | FP-18 disodium | 2936622-27-2 | FP-18 disodium is a TLR-4 agonist and vaccine adjuvant. |
|
V119890 | FP-20 sodium | 3056013-47-6 | FP-20 sodium is a selective TLR4 agonist and vaccine adjuvant. |
|
V136334 | FP20Rha | 2892104-75-3 | FP20Rha is a potent TLR4 agonist. |
|
V51032 | FSL-1 | 322455-70-9 | FSL-1 is a bacterially derived Toll-like receptor 2/6 (TLR2/6) agonist that enhances resistance to HSV-2 infection. |
|
V79522 | FSL-1 TFA | FSL-1 TFA is a bacterially derived Toll-like receptor 2/6 (TLR2/6) agonist that enhances resistance to HSV-2 infection. | |
|
V103270 | Ganglioside GD1a | 12707-58-3 | Ganglioside GD1a regulates the toxic and inflammatory effects of Escherichia coli lipopolysaccharide by preventing TLR4 translocation to lipid rafts. |
|
V110403 | Ganglioside GT1b (bovine) trisodium | Bovine ganglioside GT1b trisodium is a trisialic acid ganglioside. | |
|
V102481 | Gardiquimod hydrochloride | 2956183-81-4 | Gardiquimod (hydrochloride) is an imidazoline TLR7/8 agonist. |
|
V120265 | GNE-5152 | 3080315-83-6 | GNE-5152 is an ortho-SARM1 base exchange (BE) inhibitor. |
|
|
V116847 | GNKG168 | 2243120-19-4 | GNKG168 is an unmethylated CpG oligonucleotide. |
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
