TLR

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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TLR

A group of proteins known as toll-like receptors (TLRs) are essential components of the innate immune system. They are single, membrane-spanning, non-catalytic receptors that recognize structurally conserved molecules derived from microbes and are typically expressed in sentinel cells like macrophages and dendritic cells. Once these microbes have gotten past physical barriers like the skin or mucosa of the gastrointestinal tract, TLRs recognize them and trigger immune cell responses.

TLR1 through TLR13 are among the TLRs, along with TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TLR10, TLR11, TLR12, and TLR13. Toll-Like Receptors (TLRs) are involved in both the detection of endogenous danger signals and the early innate immune response to encroaching pathogens. TLRs are homologs of the Drosophila Toll protein, which was found to be crucial for defense against microbial infection. They are evolutionarily conserved receptors. TLRs identify pathogen-associated microbial patterns (PAMPs), which are only expressed by microbial pathogens and are highly conserved structural motifs.

TLR related products

Cat No.	Product Name	CAS No.	Product Description
V132466	Creatine ethyl ester	15366-29-7	Creatine ethyl ester is a commonly used and readily available form of creatine in supplements.
V51027	CU-115	2471982-20-2	CU-115 is a disabling TLR8 antagonist (IC50=1.04 µM) and shows activity against TLR8 and TLR7 (IC50=>50 µM).
V3815	CU-CPT-8m	125079-83-6	CU-CPT-8m is a novel, potent and specific antagonist ofToll-like receptor 8 (TLR8)with immunomodulatory effects.
V3816	CU-CPT-9a	2165340-32-7	CU-CPT-9a, an analog ofCU-CPT-8m, is a potent and specificantagonist/inhibitor of TLR8 (Toll-like receptor 8) (IC50 = 0.5 nM) with the potential to be used for treating autoimmune diseases.
V3817	CU-CPT-9b	2162962-69-6	CU-CPT-9b, an analog ofCU-CPT-8m and CU-CPT-9a, is a specificantagonist of TLR8 (Toll-like receptor 8) with IC50 of 0.7 nM.
V3818	CU-CPT17e	2109805-75-4	CU-CPT17e is a multi-TLR (Toll-like receptor) agonist that activates TLR3, TLR8, and TLR9 with immunomodulatory activities.
V18880	CU-T12-9	1821387-73-8	CU-T12-9 (CU T12-9; CU-T129) is a novel and potent TLR1/2 (Toll-like receptor) agonist with potential immunemodulatory and antitumor effects.
V74352	DB-3-291	2769753-64-0	DB-3-291 is a potent and specific CSK degrader with Kd of 1 nM.
V99684	Defoslimod	171092-39-0	Defoslimod (OM 174) is a TLR4 receptor agonist that acts as an immunomodulator.
V134382	DSP30		DSP30 is a phosphate thioester-modified cpG oligodeoxynucleotide and a TLR9 agonist.
V37618	DSR-6434	1059070-10-8	DSR-6434 (DSR6434) is a novel and selective Toll-like receptor 7 (TLR7) agonist with antitumor effects.
V115695	E-5531	162679-36-9	E-5531 is an endotoxin antagonist.
V83241	E-6742	1700609-11-5	E-6742 is a novel TLR7/8 inhibitor being developed for the treatment of systemic lupus erythematosus (SLE).
V74378	E104	1610431-21-4	E104 (compound 1) is a potent and specific TLR7 agonist.
V20341	E6446	1219925-73-1	E6446 is a potent, orally bioavailable TLR7 and TLR9 antagonist for the study of harmful inflammatory responses.
V20340	E6446 HCl	1345675-25-3	E6446 is a synthetic antagonist of nucleic acid-sensing TLRs.
V74372	Enpatoran hydrochloride (M5049 hydrochloride)	2101945-93-9	Enpatoran (M5049) HCl is a potent, orally bioactive TLR7/8 inhibitor (antagonist) with IC50s of 11.1 nM and 24.1 nM in HEK293 cells, respectively.
V53258	Eritoran	185955-34-4	Eritoran is a Toll-like receptor 4 (TLR4) antagonist.
V117526	ETI41	2773474-99-8	ETI41 is an orally effective selective TLR inhibitor that targets nucleoside binding site I of TLR7 (IC50 = 0.63 μM) and TLR9 (IC50 = 0.16 μM) without affecting surface TLRs (including TLR1/TLR2, TLR2/TLR6, TLR4, and TLR5).
V117613	ETI60	2773475-11-7	ETI60 is an orally effective selective TLR inhibitor that targets nucleoside binding site I of TLR7 (IC50 = 0.68 μM) and TLR9 (IC50 = 0.12 μM) without affecting surface TLRs (including TLR1/TLR2, TLR2/TLR6, TLR4, and TLR5).