A group of proteins known as toll-like receptors (TLRs) are essential components of the innate immune system. They are single, membrane-spanning, non-catalytic receptors that recognize structurally conserved molecules derived from microbes and are typically expressed in sentinel cells like macrophages and dendritic cells. Once these microbes have gotten past physical barriers like the skin or mucosa of the gastrointestinal tract, TLRs recognize them and trigger immune cell responses.
TLR1 through TLR13 are among the TLRs, along with TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TLR10, TLR11, TLR12, and TLR13. Toll-Like Receptors (TLRs) are involved in both the detection of endogenous danger signals and the early innate immune response to encroaching pathogens. TLRs are homologs of the Drosophila Toll protein, which was found to be crucial for defense against microbial infection. They are evolutionarily conserved receptors. TLRs identify pathogen-associated microbial patterns (PAMPs), which are only expressed by microbial pathogens and are highly conserved structural motifs.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V114949 | TLR9-IN-2 | 2972638-16-5 | TLR9-IN-2 (compound 20) is a selective Toll-like receptor 9 (TLR9) inhibitor with IC50 values of 25, 1400 and >50,000 nM for TLR9, TLR7 and TLR8, respectively. |
|
V116837 | Sitmutolimod | 3002979-61-2 | Sitmutolimod is a CpG oligonucleotide, a Toll-like receptor agonist, and has antitumor activity. |
|
|
V116822 | Sitmutolimod sodium | Simotorimone sodium is a CpG oligonucleotide, a Toll-like receptor agonist, and has antitumor activity. | |
|
|
V116847 | GNKG168 | 2243120-19-4 | GNKG168 is an unmethylated CpG oligonucleotide. |
|
|
V116804 | GNKG168 sodium | GNKG168 sodium is an unmethylated CpG oligonucleotide. | |
|
V118476 | SMU-R39 | SMU-R39 is a TLR7 and TLR8 antagonist with IC50 values of 3.22 μM and 0.24 μM, respectively. | |
|
V118253 | TLR9 antagonist 1 | 3105410-45-2 | TLR9 antagonist 1 (compound 38) is a selective TLR9 antagonist with an IC50 value of 0.1 nM for hTLR9, which is superior to its antagonistic effect on hTLR2/4/5/7/8. |
|
V120188 | L07-2 | 3093296-36-4 | L07-2 (compound 6) is an active scaffold containing TLR7/8 stimulants. |
|
V120265 | GNE-5152 | 3080315-83-6 | GNE-5152 is an ortho-SARM1 base exchange (BE) inhibitor. |
|
V120349 | TLR7/8 agonist 13 | 1402802-45-2 | TLR7/8 agonist 13 is an orally effective dual agonist of TLR7 (minimum effective concentration [hTLR7] = 1.6 μM) and TLR8 (minimum effective concentration [hTLR8] = 1.6 μM). |
|
V115695 | E-5531 | 162679-36-9 | E-5531 is an endotoxin antagonist. |
|
V115689 | APG-7 | APG-7 binds to the TLR4/MD-2 interface, thereby inhibiting NO production (IC50: 24.2 μg/mL). | |
|
V115488 | SMU-L11-R | 3040320-18-8 | SMU-L11-R is a selective TLR7 agonist with an EC50 value of 0.012 μM for human TLR7. |
|
V117337 | MyD88-IN-3 | MyD88-IN-3 is an orally effective selective MyD88 inhibitor. | |
|
V118689 | (Rac)-VB-201 | 873842-97-8 | (Rac)-VB-201 is the racemic form of VB-201, a small oxidized phospholipid molecule that inhibits CD14 and Toll-like receptor 2-dependent innate cell activation and suppresses atherosclerosis. |
|
V116054 | NB-3 | 3109123-46-5 | NB-3 is an inhibitor of nicotinamide adenine dinucleotide (NAD) hydrolase SARM1. |
|
V119373 | TLR2 antagonist-1 | TLR2 antagonist-1 is a selective Toll-like receptor 2 (TLR2) antagonist. | |
|
V119378 | SjDX5-271v | SjDX5-271v is a negative control for SjDX5-271. | |
|
V111040 | CIAC101 | CIAC101 is a potent, blood-brain barrier-crossing TLR4 inhibitor with an IC50 value of 17.0 nM. | |
|
V111343 | Zoratolimod | Zolatolimod is a small nucleic acid and a TLR9 agonist. |
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
