The ER-membrane protein Stimulator of Interferon Genes (STING) can be activated by the 2'3'-cGAMP produced by the enzyme Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase (cGAS) in response to the binding of double-stranded DNA. To protect against microbial infection, it activates inflammatory cytokine and interferon (IFN) responses.
STING is an important cytosolic receptor for small nucleotides that is essential for both antiviral and anticancer immunity. The STING signaling pathway triggers anti-tumor immune responses and serves as a vital link between innate and adaptive immunity. In numerous studies for immunogenic tumor clearance, antiviral therapies, and vaccine adjuvants, STING agonists like endogenous cyclic dinucleotide (CDN) cyclic GMP-AMP (cGAMP) have been used.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V51261 | c-di-AMP disodium | 2734909-87-4 | Sodium c-di-AMP (cyclic diadenylate) is a STING agonist that binds to STING, thereby activating the TBK3-IRF3 signaling pathway and triggering the production of type I IFN and TNF. |
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V19990 | m-Cl-CCP (CCCP) | 555-60-2 | m-Cl-CCP [555-60-2] is a protonophore (h+ ionophore) and uncoupler of oxidative phosphorylation in mitochondria, inhibiting secretion of hepatic lipase and partially inhibiting the ph gradient-activated cl- uptake and cl-/cl- exchange activities in brush-border membrane vesicles |
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