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STING

STING

The ER-membrane protein Stimulator of Interferon Genes (STING) can be activated by the 2'3'-cGAMP produced by the enzyme Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase (cGAS) in response to the binding of double-stranded DNA. To protect against microbial infection, it activates inflammatory cytokine and interferon (IFN) responses.

STING is an important cytosolic receptor for small nucleotides that is essential for both antiviral and anticancer immunity. The STING signaling pathway triggers anti-tumor immune responses and serves as a vital link between innate and adaptive immunity. In numerous studies for immunogenic tumor clearance, antiviral therapies, and vaccine adjuvants, STING agonists like endogenous cyclic dinucleotide (CDN) cyclic GMP-AMP (cGAMP) have been used.

STING related products

Structure Cat No. Product Name CAS No. Product Description
MSA-2 V2470 MSA-2 129425-81-6 MSA 2 (MSA2;MSA-2) is a novel, orally bioactive and potent non-nucleotide agonist of stimulator of interferon genes (STING) with potential antitumor activity.
MSA-2 dimer V74312 MSA-2 dimer 2377881-92-8 MSA-2 dimer is a selective and orally bioactive non-nucleotide STING agonist (Kd=145 μM) with long-term anti-tumor and immunogenic activity.
MSA-2-Pt V84938 MSA-2-Pt
NVS-STG2 V78866 NVS-STG2 3030588-01-0 NVS-STG2 is a molecular glue targeting STING and can activate STING-mediated immune signaling.
Parent CDN V118356 Parent CDN 2228893-48-7 The parent CDN is a cyclic dinucleotide and also a STING agonist.
PDIC-NN V104585 PDIC-NN 932740-48-2 PDIC-NN is an intermediate in the synthesis of PDIC-NS, a STING activator with anticancer activity.
PPARα agonist 4 V101174 PPARα agonist 4 PPARα agonist 4 (Compound BH400) is a PPARα agonist (EC50 = 1.2 μM).
SAP-04 V79086 SAP-04 SAP-04 is a potent orally bioactive STING agonist.
SB24011 V87008 SB24011 1497415-41-4 SB24011 is a STING-TRIM29 interaction inhibitor with an IC50 value of 3.85 μM.
SH-273 V111787 SH-273 3084159-97-4 SH-273 is a dual-target compound.
Sim-9 V144946 Sim-9 3099101-40-0 Sim-9 is a covalent allosteric inhibitor of interferon regulator 3 (IRF3).
SN-008 V74314 SN-008 2249106-01-0 SN-008 is a low activity analog of SN-011 and can be used as a negative control (NC).
SN38-(PEG)2-Pom-α V110347 SN38-(PEG)2-Pom-α SN38-(PEG)2-Pom-α is a selective PROTAC RPL15 degrader.
SNX281 V88958 SNX281 2332803-84-4 SNX281 is a systemically active interferon gene (STING) agonist that binds to the STING protein, promotes signal transduction of the cGAS-STING pathway, and increases the cell response to tumor cells.
SP-23 V41902 SP-23 2762552-74-7 SP-23 (SP23) is a novel, first-in-class and potent STING-targeting PROTAC degrader based on C-170 (STING inhibitor) with anti-inflammatory effects.
SR-717 V51740 SR-717 2375420-34-9 SR-717 free acid is a non-nuclear STING-like agonist/activator with EC50s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cells, respectively.
SR-717 lithium V2205 SR-717 lithium 2375421-09-1 SR-717 lithium is a novel, potent and non-nucleotide STING (stimulator of interferon genes) agonist with anticancer activities.
ssVACV-70mer sodium V85347 ssVACV-70mer sodium
STING agonist-13 V74332 STING agonist-13 2816929-48-1 STING agonist-13 is a STING agonist that performs cancer immunity through STING-mediated immune activation.
STING agonist-14 V86118 STING agonist-14 2411100-70-2
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