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STING

STING

The ER-membrane protein Stimulator of Interferon Genes (STING) can be activated by the 2'3'-cGAMP produced by the enzyme Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase (cGAS) in response to the binding of double-stranded DNA. To protect against microbial infection, it activates inflammatory cytokine and interferon (IFN) responses.

STING is an important cytosolic receptor for small nucleotides that is essential for both antiviral and anticancer immunity. The STING signaling pathway triggers anti-tumor immune responses and serves as a vital link between innate and adaptive immunity. In numerous studies for immunogenic tumor clearance, antiviral therapies, and vaccine adjuvants, STING agonists like endogenous cyclic dinucleotide (CDN) cyclic GMP-AMP (cGAMP) have been used.

STING related products

Structure Cat No. Product Name CAS No. Product Description
endo-S-cGAFMP V135098 endo-S-cGAFMP endo-S-cGAFMP is a STING agonist.
Enpp-1-IN-25 V135114 Enpp-1-IN-25 3067908-20-4 Enpp-1-IN-25 is an ENPP1 inhibitor with an IC50 value of 8.05 nM and low oral bioavailability.
F-CRI1 V79211 F-CRI1 2991453-50-8 F-CRI1 is a potent STING agonist/activator with a Kd of 40.62 nM.
Fendiline V85588 Fendiline 13042-18-7
G3-YSD V136441 G3-YSD 2780391-08-2 G3-YSD is a cGAS agonist.
H 151 (H-151) V22028 H 151 (H-151) 941987-60-6 H151 (H-151) isa potent,selective andirreversible STING antagonist/inhibitor with the potential to be used for autoimmune diseases such as arthritis and other inflammatory conditions.
H-151 Alkyne V137044 H-151 Alkyne 2244892-03-1 H-151 Alkyne is a selective STING (interferon gene stimulating factor) inhibitor.
hSTING agonist-1 V105178 hSTING agonist-1 hSTING agonist-1 (Compound 17) is a potent agonist of hSTING.
HSV-60mer sodium V85336 HSV-60mer sodium
IACS-8803 diammonium V76903 IACS-8803 diammonium IACS-8803 diammonium is a potent cyclic dinucleotide STING agonist with potent systemic anti-tumor effects.
IACS-8803 disodium V74309 IACS-8803 disodium 2243079-36-7 IACS-8803 disodium is a potent cyclic dinucleotide STING agonist with potent systemic anti-tumor effects.
INI3069 V120287 INI3069 INI3069 is a selective human interferon gene stimulating factor (STING) agonist.
ISD Control sodium V85348 ISD Control sodium
ISD sodium V85351 ISD sodium
LA24 V110009 LA24 LA24 is a potent STING allosteric agonist with an EC₅₀ of 0.82 μM.
LB244 V80542 LB244 LB244 is a homologue of BB-Cl-amidine, which is an orally bioactive STING inhibitor (EC50=0.8 μM) and may be utilized to inhibit STING-dependent inflammatory diseases.
m-PEG8-Lys(Mal)-Val-Ala-PAB-Ph-CO-Dazostinag V100018 m-PEG8-Lys(Mal)-Val-Ala-PAB-Ph-CO-Dazostinag 2553413-13-9 m-PEG8-Lys(Mal)-Val-Ala-PAB-Ph-CO-Dazostinag is an ADC drug-linker conjugate.
Mal-Val-Ala-PAB-4-Abu(Me)-Dazostinag V99995 Mal-Val-Ala-PAB-4-Abu(Me)-Dazostinag 2553413-19-5 Mal-Val-Ala-PAB-4-Abu(Me)-Dazostinag is an ADC drug-linker conjugate.
Mal-Val-Ala-PAB-NMe-CH2CH2-O-CO-Dazostinag V99990 Mal-Val-Ala-PAB-NMe-CH2CH2-O-CO-Dazostinag 2553412-83-0 Mal-Val-Ala-PAB-NMe-CH2CH2-O-CO-Dazostinag is an ADC drug-linker conjugate.
MK-2118 V87005 MK-2118 2218504-06-2 MK-2118 is a GMP-synthesized STING agonist with the potential to inhibit advanced/metastatic solid tumors or lymphomas.
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