The ER-membrane protein Stimulator of Interferon Genes (STING) can be activated by the 2'3'-cGAMP produced by the enzyme Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase (cGAS) in response to the binding of double-stranded DNA. To protect against microbial infection, it activates inflammatory cytokine and interferon (IFN) responses.
STING is an important cytosolic receptor for small nucleotides that is essential for both antiviral and anticancer immunity. The STING signaling pathway triggers anti-tumor immune responses and serves as a vital link between innate and adaptive immunity. In numerous studies for immunogenic tumor clearance, antiviral therapies, and vaccine adjuvants, STING agonists like endogenous cyclic dinucleotide (CDN) cyclic GMP-AMP (cGAMP) have been used.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
(OC%5bC%40%5d(O%5bC%40%40H%5d(N1C2%3dNC%3dNC(N)%3dC2N%3dC1)%5bC%40%40H%5d3O)(%5bH%5d)%5bC%40%40%5d3(%5bH%5d)O4)%3dO)(%5bH%5d)%5bC%40%5d(COP4(O)%3dO)(%5bH%5d)O5)%5bC%40%40H%5d5N6C7%3dNC%3dNC(N)%3dC7N%3dC6.N.N)
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V51262 | c-di-AMP diammonium | STING agonist | |
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V74318 | C-di-IMP (Cyclic-di-IMP) | 79940-41-3 | C-di-IMP (Cyclic-di-IMP) is a STING agonist. |
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V78697 | C-di-IMP disodium (Cyclic-di-IMP disodium) | C-di-IMP disodium is a STING agonist. | |
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V119212 | CDN prodrug-1 | CDN prodrug-1 (compound 2) is a STING ligand. | |
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V74321 | CDN-A | 2586047-09-6 | CDN-A is a cyclic dinucleotide that may be utilized to prepare antibody-active molecule conjugates (ADC). |
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V5330 | cGAMP disodium (Cyclic GMP-AMP disodium; 3',3'-cGAMP disodium) | 2407516-83-8 | cGAMP (also known as Cyclic GMP-AMP; 3,3-cGAMP) is a cyclic nucleotide acting as a STING agonist. |
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V41344 | ChX710 | 2438721-44-7 | ChX710 is a biochemical that can prime the type I interferon response to cytosolic DNA, thus inducing the ISRE promoter sequence, specific cellular Interferon-Stimulated Genes (ISGs), and the phosphorylation of Interferon Regulatory Factor (IRF) 3. |
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V78816 | CL845-PAB-Ala-Val-C5-MC | CL845-PAB-Ala-Val-C5-MC is a binding STING ligand synthesized from the proprietary cyclic dinucleotide CL845. | |
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V78817 | CL845-PAB-Ala-Val-PEG4-Azide | CL845-PAB-Ala-Val-PEG4-Azide is a binding STING ligand synthesized from the proprietary cyclic dinucleotide CL845. | |
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V131938 | Clonixeril | 21829-22-1 | Clonixeril is a non-nucleotide hSTING regulator. |
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V133115 | Cytisine-platinum(IV) prodrug-1 | Cytisine-platinum(IV) prodrug-1 is a platinum(IV) prodrug containing the natural compound cytisine, which has anti-tumor cell proliferation activity. | |
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V74317 | Dazostinag (TAK-676 free base) | 2553413-86-6 | Dazostinag (TAK-676 free base) is an agonist of stimulator of interferon genes (STING) protein and has anti-tumor activity. |
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V31646 | diABZI STING agonist-1 | 2138299-33-7 | diABZI STING agonist-1 is a novel, potent and selective STING (stimulator of interferon genes) receptor agonist, with an EC50s of 130 nM for human PBMCs. |
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V31645 | diABZI STING agonist-1 trihydrochloride | 2138299-34-8 | diABZI STING agonist-1 (trihydrochloride) is a selective stimulator of interferon genes (STING) receptor agonist, with an EC50s of 130 for human PBMCs. |
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V97166 | diABZI-4 | 2138299-65-5 | diABZI-4 is an oral STING agonist with broad-spectrum antiviral activity. |
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V133676 | diABZI-a1 | 2138299-43-9 | diABZI-a1 is an ortho-STING agonist with an EC50 value of 117 nM for IFNβ in human peripheral blood mononuclear cells (PBMCs). |
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V74310 | diABZI-C2-NH2 | 2137975-93-8 | diABZI-C2-NH2 is an active analog containing primary amine function and a STING agonist. |
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V97240 | diABZI-V/C-DBCO | 3035557-60-6 | diABZI-V/C-DBCO (compound 3) is a highly potent STING agonist. |
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V85308 | dsVACV-70mer sodium | ||
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V74311 | E7766 diammonium salt | 2242635-03-4 | E7766 diammonium salt is a macrocyclic bridged STING agonist/activator with a Kd of 40 nM. |
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