A cell surface receptor called Programmed Death-1 (PD-1) serves as a T cell checkpoint and is crucial in controlling T cell exhaustion. PDL-1 or PDL-2 engagement with PD-1 causes it to become active. When the PD-1 receptor binds to its ligands, PD-L1 and PD-L2, which are expressed on cancer cells and antigen-presenting cells, it sends inhibitory checkpoint signals to activated T cells. This suppresses T-cell effector function and allows tumor immune evasion. An appealing approach for tumor immunotherapy is to block the programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) pathway.
Activated T cells, B cells, monocytes, dendritic cells, regulatory T cells, and natural killer T cells all express PD-1. It belongs to a group of immunoglobulin domain (Ig) co-receptors that affect how the T cell receptor responds when activated by an antigen-presenting cell (APC) or an infected target cell. In contrast to PD-L2, which is only and inducibly expressed on professional APCs, PD-L1 is widely expressed and constitutively on both hematopoietic and nonhematopoietic cells, including naive T and B cells, vascular endothelial cells, and pancreatic islet cells.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V75234 | PD-L1-IN-2 | 2894733-91-4 | PD-L1-IN-2 inhibits PD-L1 and is a potential tumor immune agent. |
|
V84207 | PD1-PDL1-IN 2 | 2566710-63-0 | |
|
V75202 | TPP-1 | 2426685-25-6 | TPP-1 is a potent inhibitor of PD-1/PD-L1 interaction. |
|
V21365 | Fraxinellone | 28808-62-0 | Fraxinellone is a naturally occurring anti-inflammatory agentisolated from the root bark of the Rutaceae plant, Dictamnus dasycarpus. |
|
V1972 | Sulfamethoxypyridazine (CL13494) | 80-35-3 | Sulfamethoxypyridazine (alsoknown as CL13494)is a long-acting sulfonamide antibiotic for the treatment of dermatitis herpetiformis. |
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
