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NLR

NLR

The host's innate immune system and immune homeostasis depend heavily on the cytoplasmic pattern-recognition receptors (PRRs) known as nucleotide oligomerization domain (NOD)-like receptors (NLRs). Humans have 23 members of the NLR family, while mice have at least 34 NLR genes. Although many cell types, including immune and epithelial cells, express NLRs, some NLR family members, such as macrophages and neutrophils, express them primarily in phagocytes. The NLR family is most frequently divided into one of four subfamilies based on their N-terminal domains: NLRA, NLRB, NLRC, and NLRP.

The NLRs are capable of recognizing a wide range of ligands, including those produced by microbial pathogens (peptidoglycan, flagellin, viral RNA, fungal hyphae, etc.), host cells (ATPs, cholesterol crystals, uric acid, etc.), and environmental sources (alum, asbestos, silica, alloy particles, UV radiation, skin irritants, etc.). Most NLRs function as PRRs, identifying the aforementioned ligands and inciting inflammatory reactions. Some NLRs, however, might not function as PRRs and instead react to cytokines like interferons. Four broad categories of functions performed by the activated NLRs include inflammasome formation, signal transduction, transcription activation, and autophagy.

NLR related products

Structure Cat No. Product Name CAS No. Product Description
NLRP3-IN-22 V75184 NLRP3-IN-22 1193329-98-4 NLRP3-IN-22 (Compound II-4) is an NLRP3 inhibitor (inhibition rate: 67% at 10 μM).
NLRP3-IN-23 V79047 NLRP3-IN-23 NLRP3-IN-23 (Compound 15C) is a heme-mediated inhibitor of NLRP3 inflammasome induction.
NLRP3-IN-26 V85836 NLRP3-IN-26 2927413-30-5
NLRP3-IN-27 V84943 NLRP3-IN-27 2997864-57-8
NLRP3-IN-28 V84321 NLRP3-IN-28 2922814-80-8
NLRP3-IN-29 V84283 NLRP3-IN-29 2198483-40-6
NLRP3-IN-30 V83452 NLRP3-IN-30
NLRP3-IN-31 V86926 NLRP3-IN-31 2769040-08-4 NLRP3-IN-31 (Comp 14) is a NLRP3 inhibitor with IC50 of 0.3-0.5 μM.
NLRP3-IN-34 V100280 NLRP3-IN-34 1392502-55-4 NLRP3-IN-34 (compound T10) is an inhibitor of NLRP3 inflammasome.
NLRP3-IN-35 V103930 NLRP3-IN-35 NLRP3-IN-35 (Compound 11) is a NLRP3 inhibitor (IC50 < 1 μM).
NLRP3-IN-36 V86931 NLRP3-IN-36 NLRP3-IN-36 (Compound 111) is a NLRP3 inhibitor (IC50<1 μM).
NLRP3-IN-37 V86934 NLRP3-IN-37 3033054-51-9 NLRP3-IN-37 (Compound 23) is a NLRP3 inhibitor (EC50: 5 nM).
NLRP3-IN-38 V86922 NLRP3-IN-38 3033054-46-2 NLRP3-IN-38 (Compound 18) is a NLRP3 inhibitor that inhibits NLRP3 inflammasome activation with EC50 of 23 nM.
NLRP3-IN-39 V86925 NLRP3-IN-39 NLRP3-IN-39 (Compound 49) can inhibit the assembly and activation of NLRP3 inflammasome.
NLRP3-IN-4 V75176 NLRP3-IN-4 2758595-77-4 NLRP3-IN-4 is a potent orally bioactive NLRP3 inflammasome inhibitor (antagonist) with anti~inflammatory activity in colitis.
NLRP3-IN-40 V86929 NLRP3-IN-40 NLRP3-IN-40 (compound 32) is an inhibitor of inflammasome NLRP3 that blocks NLRP3 activation induced by multiple agonists without altering NLRC4 or AIM2 inflammasomes.
NLRP3-IN-42 V86930 NLRP3-IN-42 NLRP3-IN-42 (compound H28) is a potent NLRP3 inhibitor with a KD of 1.15 µM.
NLRP3-IN-43 V86933 NLRP3-IN-43 2769903-01-5 NLRP3-IN-43 (compound II-8) is a potent inhibitor of NLRP3 inflammasome activation that binds to the LRR domain and disrupts NLRP3-NEK7 interaction.
NLRP3-IN-44 V97453 NLRP3-IN-44 3040298-34-5 NLRP3-IN-44 (Compound P33) is a potent and orally active (~62%) NLRP3 inhibitor with Kd of 17.5 nM.
NLRP3-IN-45 V97463 NLRP3-IN-45 NLRP3-IN-45 (D6) is an inhibitor of NLRP3 inflammasome activation and inhibits the activity of IL-1β (IC50=41.79 nM).
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