Receptor-interacting protein (RIP) kinases are a class of threonine/serine protein kinases with distinct non-kinase regions and a comparatively conserved kinase domain. The RIPK family consists of seven members, RIPK1 to RIPK7, some of which have become important effectors of immunity against infection with a variety of bacterial, viral, and protozoal pathogens.
Both communicable and non-communicable disease processes depend on the cellular signaling molecules known as RIP kinases for homeostatic signaling. The early control of a wide range of pathogenic organisms requires the action of RIPK1, RIPK2, RIPK3, and RIPK7, which have emerged as important mediators of intracellular signal transduction including inflammation, autophagy, and programmed cell death.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V110915 | RIPK1-IN-38 | 3092834-30-2 | RIPK1-IN-38 is an orally effective RIPK1 inhibitor with an IC50 value of 27 nM. |
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V110302 | RIPK1-IN-39 | 3065634-42-3 | RIPK1-IN-39 (compound 2) is a highly potent and selective RIPK1 inhibitor (IC50 = 69.40 nM), with more than 100 times higher selectivity for RIPK1 than for RIPK3 (IC50 = 6946 nM). |
|
V119382 | RIPK1-ligand-2 | RIPK1 ligand 2 is a RIPK1 inhibitor. | |
|
V51583 | RIPK2 PROTAC degrader 1 | 2126803-41-4 | RIPK2 PROTAC degrader |
|
V79125 | RIPK2/3-IN-1 | RIPK2/3-IN-1 is a potent dual RIPK2/3 kinase inhibitor (antagonist) with IC50s of 3 nM and 117 nM respectively. | |
|
V81303 | RIPK3-IN-3 | RIPK3-IN-3 (compound 20) is a selective inhibitor of RIP kinase RIPK3 (IC50=10 nM). | |
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V76005 | RIPK3-IN-4 | 2304617-58-9 | RIPK3-IN-4 (Compound 42) is a RIPK3 inhibitor. |
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V76459 | SZM679 | 3027645-52-6 | SZM679 is an orally bioactive and selective RIPK1 inhibitor (antagonist) with Kds of 8.6 nM and >5000 nM for RIPK1 and RIPK3, respectively. |
|
V88527 | VDX-111 | 158983-23-4 | VDX-111 is a vitamin D analog. |
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V28191 | WEHI-345 | 1354825-58-3 | WEHI-345 (WEHI345) is a novel, potent and selective RIPK2 inhibitor with therapeutic potential to treat NOD-driven inflammatory diseases. |
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V114383 | ZBP1 Covalent PROTAC-1 | ZBP1 covalent PROTAC-1 is a covalent Z-DNA binding protein 1 (ZBP1 PROTAC) degrader with a DC50 value of 25.69 nM. | |
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V88525 | ZBP1/RIP3/MLKL activator 1 | ZBP1/RIP3/MLKL activator 1 (compound 3a) is a synthetic monoquinoline derivative. | |
|
V29086 | Necrostatin 2 S enantiomer | 852391-20-9 | Necrostatin 2 S-isomer is the S-enantiomer of Necrostatin 2 (also known asNecrostatin-2, Necrostatin-2 racemate, (±)-Necrostatin-2, 7-Cl-O-Nec-1 and Nec-1s) which is a potent necroptosis inhibitor with EC50 of 50 nM. |
|
V50928 | Reduced haloperidol | 34104-67-1 | active metabolite of haloperidol |
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