PD-1 PD-L1

PD-1 PD-L1

A cell surface receptor called Programmed Death-1 (PD-1) serves as a T cell checkpoint and is crucial in controlling T cell exhaustion. PDL-1 or PDL-2 engagement with PD-1 causes it to become active. When the PD-1 receptor binds to its ligands, PD-L1 and PD-L2, which are expressed on cancer cells and antigen-presenting cells, it sends inhibitory checkpoint signals to activated T cells. This suppresses T-cell effector function and allows tumor immune evasion. An appealing approach for tumor immunotherapy is to block the programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) pathway.

Activated T cells, B cells, monocytes, dendritic cells, regulatory T cells, and natural killer T cells all express PD-1. It belongs to a group of immunoglobulin domain (Ig) co-receptors that affect how the T cell receptor responds when activated by an antigen-presenting cell (APC) or an infected target cell. In contrast to PD-L2, which is only and inducibly expressed on professional APCs, PD-L1 is widely expressed and constitutively on both hematopoietic and nonhematopoietic cells, including naive T and B cells, vascular endothelial cells, and pancreatic islet cells.

PD-1 PD-L1 related products

Structure Cat No. Product Name CAS No. Product Description
V3676 (-)-JQ-1 1268524-71-5 JQ-1 is the (R)-Enantiomer of JQ1 or the stereoisomer of (+)-JQ1.
V77385 (D)-PPA 1 TFA (D)-PPA 1 TFA is a hydrolytic D-peptide antagonist.
V2635 Atazanavir 198904-31-3 Atazanavir (also called Latazanavir, Zrivada, Reyataz, BMS-232632)is an azapeptide and HIV-protease inhibitor that is used in the treatment of HIV infections and AIDS in combination with other anti-HIV agents.
V3096 AUNP-12 1353563-85-5 AUNP-12 (also known as Aur-012, Aurigene-012, and Aurigene NP-12), a novel and potent immune checkpoint modulator developed by Aurigene Discovery Technologies, is an inhibitor of thePD-1 signalling pathway with an EC50 of 0.72 nM in the inhibition of binding PD1 to PD-L2 using hPDL2expressing HEK293 cells, and an EC50 of 0.41 nM in a rat peripheral blood mononuclearcells (PBMC) proliferation assay using hPDL1 expressing MDA-MB231 cells.
V77227 AUNP-12 TFA (NP-12 TFA) AUNP-12 (NP-12) TFA is a bioactive peptide antagonist of the PD-1 signaling pathway and has equivalent antagonistic effects on PD-L1 and PD-L2 in inhibiting lymphocyte proliferation and effector functions.
V3097 BMS-1 1675201-83-8 BMS-1(also known as PD1-PDL1-IN1, or PD1/PD-L1 inhibitor 1) isa novel and highly potent small molecule inhibitor ofPD-1/PD-L1 protein/protein interactionwith an IC50of 6 nM.
V3674 BMS-1001 113650-03-4 BMS-1001 is a novel and potent small molecule inhibitor of the PD-1/PD-L1 protein protein interaction with IC50 value of 2.25 nM in cell free assays.
V3675 BMS-1166 1818314-88-3 BMS-1166 is a novel and potent small molecule inhibitor of the PD-1/PD-L1 protein protein interaction with IC50 value of 1.6 nM in cell free assays.
V60028 BMS-1233 2447065-99-6 BMS-1233 (BMS1233) is novel and potent small molecule inhibitor of the PD-1/PD-L1 protein protein interaction with an IC50 of<100 nM in the HTRF assay.
V3678 BMS-200 1675203-82-3 BMS-200 is a novel and potent small molecule inhibitor of the PD-1/PD-L1 protein protein interaction with IC50 value of 80 nM in cell free assays.
V0770 BMS-202 1675203-84-5 PD1-PDL1 inhibitor 2 (also known as BMS-202, BMS 202, BMS202), is a novel and potent inhibitor of the PD-1 (Programmed death- 1)/PD-Ll (Programmed death-ligand 1) protein/protein interaction with potential antineoplastic activity.
V3677 BMS-242 1675204-51-9 BMS-242 is a novel and potent small molecule inhibitor of the PD-1/PD-L1 protein protein interaction with IC50 value in the range of 6-100 nM in cell free assays.
V3256 BMS-8 1675201-90-7 BMS-8is a novel small molecule inhibitor of the PD-1 (Programmed death-1)/PD-L1 (Programmed death-ligand 1) protein/protein interaction with potential anticancer activities.
V77194 BMSpep-57 hydrochloride BMSpep-57 HCl is a potent macrocyclic peptide inhibitor that can suppress PD-1/PD-L1 interaction with IC50 of 7.68 nM.
V78692 CD24/Siglec-10 blocking peptide, CSBP CD24/Siglec-10 blocking peptide, CSBP can not only block the interaction of CD24/Siglec-10, but also block PD-1/PD-L1.
V36345 CP21 CP21is a bifunctional immunomodulatory small molecule targeting PD-L1 and CXCL12 with high affinities.
V78968 CYP51/PD-L1-IN-1 CYP51/PD-L1-IN-1 (compound L11) is a quinazoline compound with antifungal activity.
V78904 CYP51/PD-L1-IN-2 CYP51/PD-L1-IN-2 (compound L20) is a quinazoline compound with antifungal activity.
V78665 CYP51/PD-L1-IN-3 CYP51/PD-L1-IN-3 (compound L21) is a quinazoline compound with antifungal activity.
V78667 CYP51/PD-L1-IN-4 CYP51/PD-L1-IN-4 (compound 14a-2) is a potent dual-target (CYP51/PD-L1) inhibitor (antagonist) with IC50s of 0.17 and 0.021 μM, respectively.
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