The founding member of a newly identified family of Ser/Thr kinases, DAPK (Death-Associated Protein Kinase), shares functions with other members of the family that are related to cell death as well as significant homology in their catalytic domains. An impressive body of literature has been written about the function, regulation, and relationship to disease of the kinase family as a result of the discovery that DAPk is a tumor suppressor gene, whose expression is lost in a variety of tumor types. The DAPk family has been suggested to serve purposes aside from cell death and has been connected to a number of signaling pathways related to cell death.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V76002 | CK156 | 2910938-59-7 | CK156 is a selective death-associated protein kinase (DAPK) inhibitor. |
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V77106 | DAPK Substrate Peptide TFA | DAPK Substrate Peptide TFA is a synthetic death-associated protein kinase (DAPK) peptide substrate with a Km of 9 μM. | |
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V15912 | TC-DAPK 6 | 315694-89-4 | TC-DAPK 6 is a novel, potent, ATP-competitive, and highly selective death-associated protein kinase (DAPK) inhibitor withIC50of 69 and 225 nM against DAPK1 and DAPK3, respectively, with 10 μM ATP. |
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