A family of proteins known as Bcl-2 have evolutionary connections. These proteins, which include Bcl-2 proper, Bcl-xL, and Bcl-w among a variety of others, control mitochondrial outer membrane permeabilization (MOMP). They can either be pro- or anti-apoptotic. The Bcl-2 family comprises a total of 25 known genes. These human genes include Bak1, Bax, Bal-2, Bok, and Mcl-1, which code for members of this family of proteins.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V88443 | WH244 | 2941088-96-4 | WH244 is a second-generation BCL-2 and BCL-xL dual degrader (PROTAC). |
|
V81754 | WK499 | BCL6-IN-10 (Compound WK499) is a BCL6 inhibitor. | |
|
V105019 | XY221 | XY221 (compound 16o) selectively inhibits BRD4 BD2 with IC50 of 5.8 nM. | |
|
V89587 | Zamzetoclax | 2388470-64-0 | Zamzetoclax (compound 1) is a potential Mcl-1 inhibitor. |
|
V0007 | HA14-1 | 65673-63-4 | HA14-1 is a novel, potent and non-peptidic inhibitor of a B-cell lymphoma 2 (Bcl-2)surface pocket with IC50 of ~9 μM. |
|
V0004 | Obatoclax Mesylate (GX15-070) | 803712-79-0 | Obatoclax Mesylate (also known as GX15 070), the mesylate salt of obatoclax, is a potent inhibitor of Bcl-2 (B-cell leukemia protein-2) protein with a Ki of 0.22 μM in a cell-free assay. |
|
V10003 | Gossypol | 303-45-7 | Gossypol binds to Bcl-xL protein and Bcl-2 protein respectively, with Kis of 0.5-0.6 μM and 0.2-0.3 mM respectively. |
|
V22815 | Jaceosidin | 18085-97-7 | Jaceosidin is a flavonoid obtained from Artemisia vestita, which can activate Bax, downregulate the expression of Mcl-1 and c-FLIP, and cause apoptosis of cancer/tumor cells. |
|
V28471 | Zeaxanthin | 144-68-3 | Zeaxanthin is a naturally occurring carotenoid and one of the most common carotenoid alcohols found in nature. |
|
V0001 | Venetoclax (ABT-199; GDC-0199) | 1257044-40-8 | Venetoclax (formerly known as ABT-199 or GDC-0199; Venclexta) is a potent, selective andorally bioavailablesmall molecule inhibitor of theanti-apoptotic protein BCL-2 (B-cell lymphoma-2) with Ki of<0.01 nM. |
|
V0003 | Navitoclax (ABT-263) | 923564-51-6 | Navitoclax (formerly ABT-263) is a novel, highly potent,orally bioavailable small-molecule inhibitor of the BCL (B-cell leukemia) protein family such as Bcl-xL, Bcl-2 and Bcl-w with Ki of ~ 0.5 nM, ~1 nM and ~1 nM in cell-free assays. |
|
V2775 | Marinopyrrole A (Maritoclax) | 1227962-62-0 | Marinopyrrole A (also known as Maritoclax) is a natural product and a selective antagonist of Mcl-1 with anticancer activity. |
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
