The coronavirus (CoV) that causes severe acute respiratory syndrome, or SARS, is called SARS-CoV. CoVs, which are enveloped viruses with positive-sense, single-stranded RNA and can target the human respiratory system to spread disease, include not only the SARS virus but also MERS and SARS-CoV-2, which is the source of COVID-19.
The spike (S), membrane (M), envelope (E), and nucleocapsid (N) proteins are the four main structural proteins of CoVs. By binding to a cellular receptor (ACE2 for SARS-CoV and SARS-CoV-2, DPP4 for MERS-CoV), an S protein mediates the CoV entry into host cells, which is followed by the fusion of the virus and host cell membranes. Following entry, a large number of nonstructural proteins, including Mpro (main protease or 3CLpro), PLpro (papain-like protease), and RdRp (RNA-dependent RNA polymerase), participate in genome replication and subgenomic RNA transcription.The structural proteins are then translated, put together into mature virions, and exocytosed to release them via vesicles. It is noteworthy that a protease known as TMPRSS2 (transmembrane protease, serine 2), which cleaves S protein, plays crucial roles throughout the entire life of CoVs (such as attachment, assembling, and release). For the treatment of diseases brought on by CoVs, all the proteins and subcellular structures involved in the life cycle of CoVs are promising targets.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V76090 | CMX990 | 2882934-64-5 | CMX990 is a SARS-CoV-2 3CL protease inhibitor. |
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V54435 | Cnicin | 24394-09-0 | Cnicin is a sesquiterpene lactone. |
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V76076 | Coronastat (NK01-63) | 2922281-15-8 | Coronastat is a potent inhibitor of the SARS-CoV-2 3CL protease. |
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V132087 | Corticostatin, human TFA | Corticostatin, human TFA, is an antimicrobial peptide with antiviral activity. | |
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V84453 | Covidcil-19 | 1225177-95-6 | |
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V76094 | Crexavibart (BMS-986413; C-144-LS) | 2599039-61-7 | Crexavibart (BMS-986413; C-144-LS) is an IgG1λ2 antibody targeting the SARS-CoV2 spike (S) glycoprotein receptor binding domain. |
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V86311 | CTSL/B-IN-1 | ||
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V78997 | D-4-77 | D-4-77 is a potent inhibitor of SARS-CoV-2 Mpro with IC50 of 0.95 μM. | |
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V76088 | D1N52 | 2894770-48-8 | D1N52 is a potent SARS-CoV-2 3CLpro inhibitor (antagonist) with IC50 of 0.53 μM. |
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V76078 | D1N8 | 2894770-40-0 | D1N8 is a potent SARS-CoV-2 3CLpro inhibitor (antagonist) with IC50 and CC50 values of 0.44 μM and >20 μM, respectively. |
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V133159 | Dabcyl-KTSAVLQSGFRKME-Edans TFA | Dabcyl-KTSAVLQSGFRKME-Edans TFA is a fluorescent peptide. | |
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V54437 | Debrisoquin (Debrisoquine; Isocaramidine; Ro 5-3307/1) | 1131-64-2 | Debrisoquin (Isocaramidine) is a TMPRSS2 inhibitor that can suppress SARS-CoV-2 entry into human lung cell lines in a TMPRSS2-dependent manner with IC50 of 22 μM. |
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V112665 | Demexiptiline | 24701-51-7 | Demetriptyline is a tricyclic antidepressant, belonging to the norepinephrine reuptake inhibitor class. |
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V133568 | Dexamethasone acetate-d5 | Dexamethasone acetate-d5 is a deuterated dexamethasone acetate. | |
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V52800 | Dexamethasone-d5 (Hexadecadrol-d5; Prednisolone F-d5) | 358731-91-6 | Dexamethasone-d5 is the deuterated form of Dexamethasone. |
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V79136 | Dihydromaniwamycin E | 3033567-35-7 | Dihydromaniwamycin E is a heat shock metabolite with anti-viral effect against influenza and SARS-CoV-2 viruses. |
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V134007 | DMA-155 | 2237925-69-6 | DMA-155 is an antiviral agent that binds to the 5' stem-circular RNA of SARS-CoV-2 with affinities of 51.1 μM (SL1), 61.1 μM (SL4), 54.5 μM (SL5a), 66.9 μM (SL5b), and 48.6 μM (SL6). |
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V134134 | DNJ-20 | 3081926-49-7 | DNJ-20 is an α-glucosidase inhibitor (IC50: 55.3 μg/mL). |
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V79233 | E07 aptamer | SARS-CoV-2 nsp14-IN-4 (Compound 12q) is a selective inhibitor of SARS-CoV-2 nsp14 methyltransferase with IC50 of 19 ± 2.5 nM. | |
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V39191 | EIDD-1931 (Beta-d-N4-hydroxycytidine; NHC) | 3258-02-4 | EIDD-1931(EIDD1931; Beta-d-N4-hydroxycytidine; NHC) is anovel and potentribonucleoside analog with antiviral activity. |
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