The coronavirus (CoV) that causes severe acute respiratory syndrome, or SARS, is called SARS-CoV. CoVs, which are enveloped viruses with positive-sense, single-stranded RNA and can target the human respiratory system to spread disease, include not only the SARS virus but also MERS and SARS-CoV-2, which is the source of COVID-19.
The spike (S), membrane (M), envelope (E), and nucleocapsid (N) proteins are the four main structural proteins of CoVs. By binding to a cellular receptor (ACE2 for SARS-CoV and SARS-CoV-2, DPP4 for MERS-CoV), an S protein mediates the CoV entry into host cells, which is followed by the fusion of the virus and host cell membranes. Following entry, a large number of nonstructural proteins, including Mpro (main protease or 3CLpro), PLpro (papain-like protease), and RdRp (RNA-dependent RNA polymerase), participate in genome replication and subgenomic RNA transcription.The structural proteins are then translated, put together into mature virions, and exocytosed to release them via vesicles. It is noteworthy that a protease known as TMPRSS2 (transmembrane protease, serine 2), which cleaves S protein, plays crucial roles throughout the entire life of CoVs (such as attachment, assembling, and release). For the treatment of diseases brought on by CoVs, all the proteins and subcellular structures involved in the life cycle of CoVs are promising targets.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V52330 | Bofutrelvir (FB2001) | 2103278-86-8 | Bofutrelvir (FB2001) is an inhibitor (blocker/antagonist) of Mpro, the main protease of SARS-CoV-2, with IC50 of 53 nM and EC50 of 0.53 μM. |
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V54380 | Bonducellpin D | 197781-85-4 | Bonducellpin D is a furanoditerpene lactone extracted from Caesarpinia minax. |
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V103789 | BPR3P0128 | 1345406-09-8 | BPR3P0128 is an oral non-nucleoside RNA-dependent RNA polymerase (RdRp) inhibitor that inhibits the activity of various SARS-CoV-2 variants with EC50 of 0.62 and 0.14 µM for SARS-CoV-2 and HCoV-229E, respectively. |
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V130812 | BZ-30 | 3028405-31-1 | BZ-30 is an orally effective broad-spectrum SARS-CoV-2 inhibitor. |
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V105339 | C-467929 | 351891-58-2 | C-467929 is a Nsp15 endoribonuclease inhibitor with IC50 of 8 μM. |
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V101430 | Canrivitug | Canrivitug is a human IgG1 lambda2 monoclonal antibody against SARS-CoV-2. | |
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V54413 | CDD-1733 | 2894104-33-5 | CDD-1733 is a non-covalent and non-peptide potent SARS-CoV-2 Mpro inhibitor (antagonist) with Ki of 12 nM. |
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V54408 | CDD-1819 | 2894104-40-4 | CDD-1819 is a non-covalent and non-peptide potent SARS-CoV-2 Mpro inhibitor (antagonist) with Ki of 5 nM. |
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V54432 | CDD-1845 | 2894104-50-6 | CDD-1845 is a non-covalent and non-peptide potent SARS-CoV-2 Mpro inhibitor (antagonist) with Ki of 3 nM. |
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V78704 | CDK9-IN-25 | CDK9-IN-25 (compound 4a) is an imidazopyrazine CDK9 inhibitor (IC50= 0.24 μM). | |
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V96913 | CDK9-IN-34 | 252725-86-3 | CDK9-IN-34 (Compound 1b) is an inhibitor of CDK9 with IC50 of 0.25 μM. |
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V101482 | CET-1 | CET-1 is an antiviral drug that inhibits SARS-CoV-2. | |
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V78762 | Chloroquine-d4 phosphate (Chloroquine-d4 phosphate) | Chloroquine-d4 (phosphate) is the deuterated form of Chloroquine phosphate. | |
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V54035 | Chloroquine-d5 (chloroquine d5) | 1854126-41-2 | Chloroquine-d5 is the deuterium labelled form of Chloroquine. |
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V53059 | Cichoriin | 531-58-8 | Cichoriin has obvious activity against SARS-CoV-2 and may become a potential candidate substance for studying severe COVID-19. |
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V131713 | CIM-834 | 3104363-32-5 | CIM-834 is an orally effective inhibitor of SARS-CoV-2 membrane proteins. |
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V101669 | Cinanserin | 1166-34-3 | Cinnamethiamine (SQ 10643) is a potent and selective 5-HT2 antagonist with Ki values of 41 and 3500 nM for 5-HT2 and 5-HT1, respectively. |
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V131848 | CK2-IN-15 | CK2-IN-15 is a selective and potent bivalent protein kinase CK2 inhibitor with an IC50 value of 51 pM. | |
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V131855 | CKP-25 | CKP-25 is a Spike RBD-ACE2 interaction inhibitor that prevents the virus from entering host cells, thereby reducing viral replication and infection. | |
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V52242 | Cleistanthin B (Diphyllin O-glucoside) | 30021-77-3 | Cleistanthin B (Diphyllin O-glucoside) is an orally bioactive arylnaphthylinolide glycoside. |
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