The coronavirus (CoV) that causes severe acute respiratory syndrome, or SARS, is called SARS-CoV. CoVs, which are enveloped viruses with positive-sense, single-stranded RNA and can target the human respiratory system to spread disease, include not only the SARS virus but also MERS and SARS-CoV-2, which is the source of COVID-19.
The spike (S), membrane (M), envelope (E), and nucleocapsid (N) proteins are the four main structural proteins of CoVs. By binding to a cellular receptor (ACE2 for SARS-CoV and SARS-CoV-2, DPP4 for MERS-CoV), an S protein mediates the CoV entry into host cells, which is followed by the fusion of the virus and host cell membranes. Following entry, a large number of nonstructural proteins, including Mpro (main protease or 3CLpro), PLpro (papain-like protease), and RdRp (RNA-dependent RNA polymerase), participate in genome replication and subgenomic RNA transcription.The structural proteins are then translated, put together into mature virions, and exocytosed to release them via vesicles. It is noteworthy that a protease known as TMPRSS2 (transmembrane protease, serine 2), which cleaves S protein, plays crucial roles throughout the entire life of CoVs (such as attachment, assembling, and release). For the treatment of diseases brought on by CoVs, all the proteins and subcellular structures involved in the life cycle of CoVs are promising targets.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V54394 | Arbemnifosbuvir | 1998705-63-7 | Arbemnifosbuvir is a nucleoviral RdRp-associated nucleotidyl transferase (NiRAN) nonstructural protein 12 (nsp12) interfering drug. |
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V129482 | AS-0017445 | AS-0017445 is an inhibitor that targets the main protease of the current coronavirus and the virus that causes the Middle East Respiratory Syndrome (MERS) outbreak. | |
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V111236 | ASF-006 sodium | Sodium ASF-006 is a tetrapod tryptophan derivative and a potent inhibitor of viral invasion. | |
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V29059 | AT-9010 | 1261253-79-5 | AT-9010 is the triphosphate bioactive metabolite of AT-527 and is a potent inhibitor of NiRAN (a function essential for viral replication). |
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V28865 | AT-9010 tetrasodium | 1621884-18-1 | AT-9010 tetrasodium is the triphosphate bioactive metabolite of AT-527 and is a potent inhibitor of NiRAN (a function essential for viral replication). |
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V29256 | AT-9010 triethylamine | 2648089-95-4 | AT-9010 triethylamine is the triphosphate bioactive metabolite of AT-527 and is a potent inhibitor of NiRAN (a function essential for viral replication). |
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V129571 | Atazanavir-d24 | 1092540-58-3 | Atazanavir-d24 is a deuterated atazanavir. |
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V52658 | Atazanavir-d5 | 1132747-14-8 | Atazanavir-d5 is the deuterium labelled form of Atazanavir. |
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V129615 | ATPase-IN-6 | 3082397-26-7 | ATPase-IN-6 is an H+/K+- ATPase inhibitor and belongs to the pyrazole derivative class. |
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V129683 | AVI-4206 | 3105041-48-0 | AVI-4206 is a selective Mac1 inhibitor with a half-maximal inhibitory concentration (C50) of 64 nM. |
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V115704 | AVI-6451 | AVI-6451 is a novel, orally effective SARS-CoV-2 Mac1 inhibitor (IC50 = 28 nM). | |
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V76074 | Aviptadil acetate (Vasoactive Intestinal Peptide acetate salt (human, rat, mouse, rabbit, canine, porcine)) | 1444827-29-5 | Aviptadil acetate is a vasoactive intestinal polypeptide (VIP) analogue with strong vasodilatory effects. |
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V79742 | Azelastine-13C,d3 hydrochloride (Azelastine 13C-d3 hydrochloride) | Azelastine-13C,d3 ( HCl) is a 13C (carbon 13)-labeled deuterated form of Azelastine HCl. | |
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V129734 | Azelastine-d3 | 758637-88-6 | Azelastine-d3 is a deuterium-labeled azelastine. |
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V129921 | BBH-4 | BBH-4 is a major protease (MPro) inhibitor of SARS-CoV-2. | |
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V52348 | Bemnifosbuvir (AT-511) | 1998705-64-8 | Bemnifosbuvir is a potent orally bioactive HCV (hepatitis C virus) viral replication inhibitor. |
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V41681 | Bemnifosbuvir hemisulfate (RG-6422; AT-527) | 2241337-84-6 | Bemnifosbuvir hemisulfate (RG-6422; AT-527), the hemisulfate salt of AT-511, is a guanosine nucleotide prodrug and orally bioactive HCV viral replication inhibitor. |
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V111960 | BFC220 | 143-85-1 | BFC220 is a covalent SARS-CoV-2 Mpro inhibitor with an IC50 of 2.77 μM. |
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V130427 | BOC-(1R,3S)-3-aminocyclopentane carboxylic acid | 161660-94-2 | BOC-(1R,3S)-3-aminocyclopentane carboxylic acid is a conformationally restricted peptide unit and a key component of SARS-CoV-2 main protease (Mpro) inhibitors. |
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V52732 | Boceprevir-d9 (EBP 520-d9; SCH 503034-d9) | 1256751-11-7 | Boceprevir-d9 is the deuterium labelled form of Boceprevir. |
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