The coronavirus (CoV) that causes severe acute respiratory syndrome, or SARS, is called SARS-CoV. CoVs, which are enveloped viruses with positive-sense, single-stranded RNA and can target the human respiratory system to spread disease, include not only the SARS virus but also MERS and SARS-CoV-2, which is the source of COVID-19.
The spike (S), membrane (M), envelope (E), and nucleocapsid (N) proteins are the four main structural proteins of CoVs. By binding to a cellular receptor (ACE2 for SARS-CoV and SARS-CoV-2, DPP4 for MERS-CoV), an S protein mediates the CoV entry into host cells, which is followed by the fusion of the virus and host cell membranes. Following entry, a large number of nonstructural proteins, including Mpro (main protease or 3CLpro), PLpro (papain-like protease), and RdRp (RNA-dependent RNA polymerase), participate in genome replication and subgenomic RNA transcription.The structural proteins are then translated, put together into mature virions, and exocytosed to release them via vesicles. It is noteworthy that a protease known as TMPRSS2 (transmembrane protease, serine 2), which cleaves S protein, plays crucial roles throughout the entire life of CoVs (such as attachment, assembling, and release). For the treatment of diseases brought on by CoVs, all the proteins and subcellular structures involved in the life cycle of CoVs are promising targets.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
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V85492 | 28-O-Imidazolyl-azepano-betulin | ||
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V125342 | 3-Deazaguanosine | 56039-11-3 | 3-Dezoguanosine (C3Guo) exhibits potent antiviral activity against SARS-CoV-2 (EC50: 1.14 μM, CC50: >200 μM, applicable to Vero E6 cells). |
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V125677 | 4"-(2-(p-Chlorophenyl)acetoxyl)spiramycin | 4"-(2-(p-Chlorophenyl)acetoxyl)spiramycin is a broad-spectrum anti-coronavirus drug whose mechanism of action is through targeting the frameshift element (FSE). | |
![4-[(7-Chloro-4-quinolinyl)amino]-1-pentanol-d4](http://www.invivochem.com/upload/1124/V126100.png)
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V126100 | 4-[(7-Chloro-4-quinolinyl)amino]-1-pentanol-d4 | 1215752-28-5 | 4-[(7-Chloro-4-quinolinyl)amino]-1-pentanol-d4 is a deuterated marker for hydroxychloroquine impurity E. |
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V128080 | ACE2-SP PPI-IN-1 | ACE2-SP PPI-IN-1 is an inhibitor of the interaction between the SARS-CoV-2 spike protein and ACE2, with an IC50 value of 2162.77 nM. | |
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V79841 | Acryl42-10 | Acryl42-10 is a covalent/irreversible inhibitor of SARS-CoV-2 Nsp14 N7-methyltransferase (IC50= 7 μM). | |
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V52427 | Alunacedase alfa (HrsACE2; GSK 2586881) | 2416824-55-8 | Alunacedase alfa (HrsACE2; GSK 2586881) is a human recombinant soluble angiotensin-converting enzyme 2 (hrsACE2). |
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V128655 | Amb929 | 438196-25-9 | Amb929 is an nsp3 ligand with anti-SARS-CoV-2 virus activity. |
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V128785 | Amprenavir-13C6 | Amprenavir-13C6 is 13C-labeled amprenavir. | |
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V52736 | Amprenavir-d4 (Amprenavir-d4) | 1217661-20-5 | Amprenavir-d4 is the deuterium labelled form of Amprenavir. |
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V128861 | Antcin B | 163597-25-9 | Antcin B is a SARS-CoV-2 3-chymotrypsin-like protease (3CL Pro) inhibitor. |
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V114467 | Anticoronavirus agent-1 | 75445-60-2 | Anti-coronavirus drug-1 (compound IV-2) is a 1,4-naphthone compound that inhibits the 3C-like protease (3CL) of the novel coronavirus (19-nCoV). |
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V78033 | Antimicrobial agent-10 | Antimicrobial agent-10 is a SARS-CoV-2 inhibitor (antagonist) with excellent anti-bacterial effect. | |
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V78034 | Antimicrobial agent-11 | Antimicrobial agent-11 is a SARS-CoV-2 inhibitor (antagonist) with antimicrobial effect. | |
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V78035 | Antimicrobial agent-12 | Antimicrobial agent-12 is an effective antimicrobial agent with SARS-CoV-2 inhibitory activity. | |
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V54433 | Antioxidant agent-9 | 71835-79-5 | Antioxidant agent-9 is a bioactive peptide with the sequence Asp-Trp. |
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V54427 | Antiviral agent 25 | 2761367-25-1 | antiviral compound 25 (compound 6g) is a new non-peptide mimetic covalent inhibitor of SARS-CoV-2 3CLpro. |
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V84450 | Antiviral agent 46 | 877660-90-7 | |
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V53358 | Antiviral agent 5 | 2698336-82-0 | antiviral compound 5 is an intermediate for antiviral active molecules targeting 3C and 3CL proteases like: SARS-CoV-2 Mpro. |
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V129237 | Apigenin 7,4'-di-O-alloside | 95693-63-3 | Apigenin 7,4'-di-O-alloside is a flavonoid glycoside compound with anti-SARS-CoV-2 virus activity. |
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