Three protein-tyrosine kinases (VEGFR1, VEGFR2, and VEGFR3) and two non-protein kinase co-receptors (neuropilin-1 and neuropilin-2) make up the vascular endothelial growth factor (VEGF) family of receptors. The extracellular component of VEGFRs, which has seven immunoglobulin-like domains, one transmembrane domain, and a split tyrosine kinase domain, make up typical tyrosine kinase receptors (TKRs). VEGFR-1 binds to VEGF-A, -B, and PlGF; VEGFR-2 is activated by VEGF-A, -C, -D, and -E; and VEGFR-3 is particular to VEGF-C and -D.The consensus model for ligand-induced activation of RTKs states that VEGF binds to a cognate VEGFR to cause receptor dimerization, which then triggers the activation of protein kinases, autophosphorylation of tyrosine residues in the intracellular domains of the receptor, and the initiation of signaling pathways like PI3K/AKT and MAPK/ERK1/2. VEGFR signaling is tightly controlled at many different levels, including receptor expression levels, the availability and affinities of its various ligands for binding, the presence of VEGF-binding co-receptors, non-VEGF-binding auxiliary proteins, and inactivating tyrosine phosphatases, as well as the rate of receptor cellular uptake, extent of receptor degradation, and speed of recycling.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V129311 | APX004 | APX004 is a humanized monoclonal antibody that targets VEGF2. | |
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V129389 | Arginyl-Glutamine TFA | Arginyl-Glutamine TFA is a dipeptide that can reduce VEGF levels and inhibit retinal neovascularization in a mouse model of oxygen-induced retinopathy. | |
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V69533 | Axitinib-13C,d3 (AG-013736-13C,d3) | 1261432-00-1 | Axitinib-13C,d3 is a 13C (carbon 13)-labeled and deuterated Axitinib. |
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V69627 | Axitinib-d3 (AG-013736-d3) | 1126623-89-9 | Axitinib-d3 is the deuterated form of Axitinib. |
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V106027 | Azaspirene | 461644-34-8 | Azaspirene ((-)-Azaspirene) is an inhibitor of angiogenesis and Raf-1 activation isolated from the fungus Neosartorya sp. |
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V129902 | BAT5906 | BAT5906 is a human monoclonal antibody (mAb) that targets VEGFA. | |
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V69636 | Bevasiranib | 959961-96-7 | Bevasiranib is an siRNA that silences the gene that produces vascular endothelial growth factor (VEGF). |
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V69632 | Bevasiranib sodium | 849758-52-7 | Bevasiranib sodium is an siRNA that silences the gene that produces vascular endothelial growth factor (VEGF). |
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V130121 | BHEPN | BHEPN is a vascular endothelial growth factor receptor 2 (VEGFR-2) inhibitor. | |
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V131157 | CAY10781 | 1210360-87-4 | CAY10781 is an inhibitor of the interaction between neurociliacin-1 (NRP-1) and VEGF-A. |
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V69626 | CBO-P11 | 612096-46-5 | CBO-P11 specifically binds to the VEGFR-2 receptor and serves as a targeting ligand for tumor angiogenesis. |
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V69621 | Conbercept (KH902) | 1227158-72-6 | Conbercept (KH902) is a monoclonal antibody (mAb) targeting VEGFRA fused to the IGHG1 Fc fragment. |
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V69455 | CP-547632 TFA | 2805804-54-8 | CP-547632 TFA is an orally bioactive, ATP-competitive inhibitor of VEGFR-2 and FGF kinases with IC50s of 11 nM and 9 nM, respectively. |
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V103933 | CPD-002 | 2617376-08-4 | CPD-002 is an inhibitor of vascular endothelial growth factor receptor 2 (VEGFR 2) that inhibits angiogenesis by inhibiting the VEGFR2/PI3K/AKT signaling pathway. |
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V120286 | DOTA-TMVP1446 | DOTA-TMVP1446 is a peptide that targets VEGFR-3. | |
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V134914 | Efclarofusp alfa | 3053638-35-7 | Efclarofusp alfa is a CHO-expressed humanized antibody formed by the fusion of VEGFR-1 and VEGFR-2 regions with human IgG1 Fc. |
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V69620 | Efdamrofusp alfa | 2375661-82-6 | Efdamrofusp alfa is a bispecific fusion protein. |
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V112721 | EG01449 | EG01449 is a quinoline neurocilione-1 (NRP1) antagonist with a Kd value of 0.6 µM. | |
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V109957 | EG01449 Free acid | EG01449 free acid is a quinoline neurocilione-1 (NRP1) antagonist with a Kd value of 0.6 µM. | |
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V116479 | EGFR/VEGFR2-IN-9 | EGFR/VEGFR2-IN-9 (compound 9b) is an inhibitor of VEGFR-2 (IC50 = 1.325 μM) and EGFR (IC50 = 1.891 μM). |
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