Src, Yes, Fyn, and Fgr make up the SrcA subfamily, while Lck, Hck, Blk, and Lyn belong to the SrcB subfamily, and Frk has its own subfamily. The Src family kinase (SFK) family of non-receptor tyrosine kinases has nine members in total. Src-family kinases (SFKs) have been identified as important immune cell regulators of numerous intracellular signaling pathways.Src-family kinases (SFKs) participate in a number of signaling transduction cascades, including those originating from integrins, growth factor receptors, T and B cell antigen receptors, and Fc receptors. Src-family kinases (SFKs) can play both positive and negative regulatory roles in cellular signaling.By phosphorylating immunoreceptor tyrosine-based inhibitory motifs (ITIMs) on inhibitory receptors, they can attract and activate inhibitory molecules like the phosphatases SHP-1 and SH2 containing 5′ inositol phosphatase (SHIP-1) and act as negative regulators of cellular signaling.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V0665 | Bosutinib (SKI-606; Bosulif) | 380843-75-4 | Bosutinib (formerly also known as SKI-606; trade name Bosulif) is a novel, quinolone-based, andpotent dual Src/Abl kinase inhibitor with potential antitumor activity. |
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V0668 | PP1 | 172889-26-8 | PP1 (known also as EI275; EI-275; PP-1; PP 1; AG1872; AG-1872) is a novel, potent and selective Src kinase inhibitor with potential antitumor activity. |
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V0667 | PP2 (AG1879) | 172889-27-9 | PP2 (also known as AG 1879; AG-1879) a novel, potent,reversible, and ATP-competitiveand selective Src family kinase inhibitor with potential anticancer activity. |
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V0664 | Saracatinib (AZD0530) | 379231-04-6 | Saracatinib (formerly also known as AZD-0530; AZD0530) is a novel, potent Src kinase inhibitor with potential antineoplastic activity. |
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V0093 | Src I1 | 179248-59-0 | Src Inhibitor 1 (Src-I1) is a novel, potent and selective dual site inhibitor of Srctyrosine kinaseswith potential anticancer activity. |
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V0669 | SU6656 | 330161-87-0 | SU 6656 (SU-6656) is a novel, potent and selective Src family kinase (Src, Yes, Lyn, and Fyn) inhibitor with potential antineoplastic activity. |
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V0666 | Tirbanibulin (KX2391; KX-O1) | 897016-82-9 | Tirbanibulin (also known as KXO1; KX2-391; Klisyri) is novel, potent and the first clinical peptidomimetic Src kinase inhibitor as well as a mitotic/tubulin inhibitor with potential anticancer activity. |
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V3287 | UM-164 | 903564-48-7 | UM-164, a dasatinib analogue, isa potent and dual inhibitor of the Src/p38 kinase with potential anticancer activity for Triple-Negative Breast Cancer (TNBC). |
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V0670 | WH-4-023 | 837422-57-8 | WH-4-023 (also called KIN112;WH-4023;KIN-001-112) is a novel, potent,selectiveand orally bioactive inhibitor ofSrc family kinase(dual Lck/Src inhibitor)with potential anti-inflammatory and anticancer activity. |
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