YAP

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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YAP

YAP (Yes-associated protein) regulates cell growth, tissue homeostasis, and organ size as a transcription co-activator in the Hippo tumor suppressor pathway. The kinase Lats inhibits YAP by phosphorylating it, causing it to localize to the cytoplasm and be degraded by proteasomes. By attaching to transcription factors from the TEAD family, YAP stimulates the expression of genes.

YAP has a complicated role in human cancer that may vary depending on the cell type. For instance, by inducing apoptosis in response to DNA damage, YAP may act as a tumor suppressor in some cell types, such as hematological cancers.

YAP related products

Cat No.	Product Name	CAS No.	Product Description
V85490	VT02956 hydrochloride
V147037	VT101	65194-64-1	VT101 is a TEAD inhibitor with an IC50 of 454 nM.
V147038	VT102	1119382-90-9	VT102 is a TEAD1 inhibitor with a human IC50 value of 391 nM.
V39633	YAP-TEAD-IN-1 TFA	1659305-79-9	YAP-TEAD-IN-1 TFA is a potent competitive peptide inhibitor of YAP-TEAD interaction (IC50=25 nM).
V69182	YAP-TEAD-IN-2	2714432-83-2	YAP-TEAD-IN-2 (compound 6) is a potent YAP-TEAD PPI (protein-protein interaction) inhibitor (antagonist) with IC50 of 2.7 nM.
V85435	YAP/TAZ inhibitor-3	2506273-81-8
V93236	YAP/TAZ inhibitor-4		YAP/TAZ inhibitor-4 (compound 45) is a YAP/TAZ inhibitor that can inhibit TEAD transcriptional activation by inhibiting the binding of YAP or TAZ to TEAD.
V104453	YAP/TAZ-TEAD-IN-2		YAP/TAZ-TEAD-IN-2 (Compound 51) is a YAP/TAZ-TEAD inhibitor that inhibits the interaction between YAP/TAZ and TEAD.
V109075	YAP/TAZ-TEAD-IN-3	2714434-41-8	YAP/TAZ-TEAD-IN-3 is a YAP/TAZ-TEAD interaction inhibitor with an IC50 of 1.8 nM.
V104967	YAP/TEAD-IN-1		YAP/TEAD-IN-1 (compound 4) is a potent YAP and TEAD inhibitor.
V147236	YL-602	3081701-84-7	YL-602 is an orally effective Hippo pathway activator.
V73474	YTP-17		YTP-17 is an orally bioactive YAP-TEAD protein-protein interaction inhibitor (antagonist) with IC50 of 4 nM.